Yi Du

  • 1474 Citations
  • 17 h-Index
20072019

Research output per year

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Research Output

  • 1474 Citations
  • 17 h-Index
  • 23 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article
2019

EGFL6 promotes breast cancer by simultaneously enhancing cancer cell metastasis and stimulating tumor angiogenesis

An, J., Du, Y., Fan, X., Wang, Y., Ivan, C., Zhang, X. G., Sood, A. K., An, Z. & Zhang, N., Mar 21 2019, In : Oncogene. 38, 12, p. 2123-2134 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

EGFR and c-Met cooperate to enhance resistance to PARP inhibitors in hepatocellular carcinoma

Dong, Q., Du, Y., Li, H., Liu, C., Wei, Y., Chen, M. K., Zhao, X., Chu, Y. Y., Qiu, Y., Qin, L., Yamaguchi, H. & Hung, M. C., Feb 15 2019, In : Cancer Research. 79, 4, p. 819-829 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism

Chen, M. K., Du, Y., Sun, L., Hsu, J. L., Wang, Y. H., Gao, Y., Huang, J. & Hung, M. C., May 24 2019, In : Journal of Biological Chemistry. 294, 21, p. 8516-8528 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1

Li, H., Li, C. W., Li, X., Ding, Q., Guo, L., Liu, S., Liu, C., Lai, C. C., Hsu, J. M., Dong, Q., Xia, W., Hsu, J. L., Yamaguchi, H., Du, Y., Lai, Y. J., Sun, X., Koller, P. B., Ye, Q. & Hung, M. C., May 2019, In : Gastroenterology. 156, 6, p. 1849-1861.e13

Research output: Contribution to journalArticle

19 Scopus citations
2018

EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer

Yamaguchi, H., Du, Y., Nakai, K., Ding, M., Chang, S. S., Hsu, J. L., Yao, J., Wei, Y., Nie, L., Jiao, S., Chang, W. C., Chen, C. H., Yu, Y., Hortobagyi, G. N. & Hung, M. C., Jan 11 2018, In : Oncogene. 37, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2017

A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma

Chen, C. T., Chen, Y. C., Du, Y., Han, Z., Ying, H., Bouchard, R. R., Hsu, J. L., Hsu, J. M., Mitcham, T. M., Chen, M. K., Sun, H. L., Chang, S. S., Li, D., Chang, P., DePinho, R. A. & Hung, M. C., Jan 1 2017, In : American Journal of Cancer Research. 7, 3, p. 657-672 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

PARP inhibitors as precision medicine for cancer treatment

Du, Y., Yamaguchi, H., Hsu, J. L. & Hung, M. C., Jul 2017, In : National Science Review. 4, 4, p. 576-592 17 p.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression

Jiao, S., Xia, W., Yamaguchi, H., Wei, Y., Chen, M. K., Hsu, J. M., Hsu, J. L., Yu, W. H., Du, Y., Lee, H. H., Li, C. W., Chou, C. K., Lim, S. O., Chang, S. S., Litton, J., Arun, B., Hortobagyi, G. N. & Hung, M. C., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3711-3720 10 p.

Research output: Contribution to journalArticle

Open Access
195 Scopus citations
2016

Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors

Du, Y., Yamaguchi, H., Wei, Y., Hsu, J. L., Wang, H. L., Hsu, Y. H., Lin, W. C., Yu, W. H., Leonard, P. G., Lee, G. R., Chen, M. K., Nakai, K., Hsu, M. C., Chen, C. T., Sun, Y., Wu, Y., Chang, W. C., Huang, W. C., Liu, C. L., Chang, Y. C. & 5 others, Chen, C. H., Park, M., Jones, P., Hortobagyi, G. N. & Hung, M. C., Feb 1 2016, In : Nature Medicine. 22, 2, p. 194-201 8 p.

Research output: Contribution to journalArticle

79 Scopus citations
2015

Nuclear functions of receptor tyrosine kinases

Du, Y., Hsu, J. L., Wang, Y. N. & Hung, M. C., Jan 1 2015, Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease. Springer New York, p. 77-109 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Phosphorylation of ezh2 at t416 by cdk2 contributes to the malignancy of triple negative breast cancers

Yang, C. C., Labaff, A., Wei, Y., Nie, L., Xia, W., Huo, L., Yamaguchi, H., Hsu, Y. H., Hsu, J. L., Liu, D., Lang, J., Du, Y., Lien, H. C., Li, L. Y., Deng, R., Chan, L. C., Yao, J., Kleer, C. G., Hortobagyi, G. N. & Hung, M. C., Feb 25 2015, In : American Journal of Translational Research. 7, 6, p. 1009-1020 12 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking

Du, Y., Shen, J., Hsu, J. L., Han, Z., Hsu, M. C., Yang, C. C., Kuo, H. P., Wang, Y. N., Yamaguchi, H., Miller, S. A. & Hung, M. C., Feb 6 2014, In : Oncogene. 33, 6, p. 756-770 15 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations
2013

Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells

Yamaguchi, H., Hsu, J. L., Chen, C. T., Wang, Y. N., Hsu, M. C., Chang, S. S., Du, Y., Ko, H. W., Herbst, R. & Hung, M. C., Feb 15 2013, In : Clinical Cancer Research. 19, 4, p. 845-854 10 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

Shen, J., Xia, W., Khotskaya, Y. B., Huo, L., Nakanishi, K., Lim, S. O., Du, Y., Wang, Y., Chang, W. C., Chen, C. H., Hsu, J. L., Wu, Y., Lam, Y. C., James, B. P., Liu, X., Liu, C. G., Patel, D. J. & Hung, M. C., May 16 2013, In : Nature. 497, 7449, p. 383-387 5 p.

Research output: Contribution to journalArticle

211 Scopus citations
2012

IKKα Activation of NOTCH Links Tumorigenesis via FOXA2 Suppression

Liu, M., Lee, D. F., Chen, C. T., Yen, C. J., Li, L. Y., Lee, H. J., Chang, C. J., Chang, W. C., Hsu, J. M., Kuo, H. P., Xia, W., Wei, Y., Chiu, P. C., Chou, C. K., Du, Y., Dhar, D., Karin, M., Chen, C. H. & Hung, M. C., Jan 27 2012, In : Molecular Cell. 45, 2, p. 171-184 14 p.

Research output: Contribution to journalArticle

Open Access
64 Scopus citations

Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2

Wang, Y. N., Lee, H. H., Lee, H. J., Du, Y., Yamaguchi, H. & Hung, M. C., May 11 2012, In : Journal of Biological Chemistry. 287, 20, p. 16869-16879 11 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations

Targeting the IKKβ/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer

Chen, C. T., Du, Y., Yamaguchi, H., Hsu, J. M., Kuo, H. P., Hortobagyi, G. N. & Hung, M. C., Oct 1 2012, In : Molecular cancer therapeutics. 11, 10, p. 2212-2221 10 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
2011

Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase

Chen, C. T., Yamaguchi, H., Lee, H. J., Du, Y., Lee, H. H., Xia, W., Yu, W. H., Hsu, J. L., Yen, C. J., Sun, H. L., Wang, Y., Yeh, E. T. H., Hortobagyi, G. N. & Hung, M. C., Aug 2011, In : Molecular cancer therapeutics. 10, 8, p. 1327-1336 10 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
2010

Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer

Yang, J. Y., Chang, C. J., Xia, W., Wang, Y., Wong, K. K., Engelman, J. A., Du, Y., Andreeff, M., Hortobagyi, G. N. & Hung, M. C., Jun 1 2010, In : Cancer Research. 70, 11, p. 4709-4718 10 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis

Cheng, X., Xia, W., Yang, J. Y., Hsu, J. L., Lang, J. Y., Chou, C. K., Du, Y., Sun, H. L., Wyszomierski, S. L., Mills, G. B., Muller, W. J., Yu, D. & Hung, M. C., Oct 1 2010, In : Cancer Research. 70, 19, p. 7684-7689 6 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway

Kuo, H. P., Lee, D. F., Chen, C. T., Liu, M., Chou, C. K., Lee, H. J., Du, Y., Xie, X., Wei, Y., Xia, W., Weihua, Z., Yang, J. Y., Yen, C. J., Huang, T. H., Tan, M., Xing, G., Zhao, Y., Lin, C. H., Tsai, S. F., Fidler, I. J. & 1 others, Hung, M. C., Feb 9 2010, In : Science signaling. 3, 108, p. ra9

Research output: Contribution to journalArticle

74 Scopus citations

The translocon Sec61β localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus

Wang, Y. N., Yamaguchi, H., Huo, L., Du, Y., Lee, H. J., Lee, H. H., Wang, H., Hsu, J. M. & Hung, M. C., Dec 3 2010, In : Journal of Biological Chemistry. 285, 49, p. 38720-38729 10 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations
2009

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

Lee, D. F., Kuo, H. P., Liu, M., Chou, C. K., Xia, W., Du, Y., Shen, J., Chen, C. T., Huo, L., Hsu, M. C., Li, C. W., Ding, Q., Liao, T. L., Lai, C. C., Lin, A. C., Chang, Y. H., Tsai, S. F., Li, L. Y. & Hung, M. C., Oct 9 2009, In : Molecular Cell. 36, 1, p. 131-140 10 p.

Research output: Contribution to journalArticle

Open Access
204 Scopus citations

Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer

Xia, W., Wei, Y., Du, Y., Liu, J., Chang, B., Yu, N. L., Huo, L. F., Miller, S. & Hung, M. C., Jul 1 2009, In : Molecular Carcinogenesis. 48, 7, p. 610-617 8 p.

Research output: Contribution to journalArticle

97 Scopus citations
2008
Open Access
2007

Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: Effects on insulin-like growth factor I signaling

Nahta, R., Yuan, L. X. H., Du, Y. & Esteva, F. J., Feb 1 2007, In : Molecular cancer therapeutics. 6, 2, p. 667-674 8 p.

Research output: Contribution to journalArticle

Open Access
171 Scopus citations