Virginia G Kaklamani

  • 5869 Citations
  • 39 h-Index
19972020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Association of Tumor-Infiltrating Lymphocytes with Homologous Recombination Deficiency and BRCA1/2 Status in Patients with Early Triple-Negative Breast Cancer: A Pooled Analysis

Telli, M. L., Chu, C., Badve, S. S., Vinayak, S., Silver, D. P., Isakoff, S. J., Kaklamani, V., Gradishar, W., Stearns, V., Connolly, R. M., Ford, J. M., Gruber, J. J., Adams, S., Garber, J., Tung, N., Neff, C., Bernhisel, R., Timms, K. M. & Richardson, A. L., Jun 1 2020, In : Clinical Cancer Research. 26, 11, p. 2704-2710 7 p.

Research output: Contribution to journalArticle

Clinical Outcomes in Early Breast Cancer with a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy Plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial

Sparano, J. A., Gray, R. J., Makower, D. F., Albain, K. S., Saphner, T. J., Badve, S. S., Wagner, L. I., Kaklamani, V. G., Keane, M. M., Gomez, H. L., Reddy, P. S., Goggins, T. F., Mayer, I. A., Toppmeyer, D. L., Brufsky, A. M., Goetz, M. P., Berenberg, J. L., Mahalcioiu, C., Desbiens, C., Hayes, D. F. & 9 others, Dees, E. C., Geyer, C. E., Olson, J. A., Wood, W. C., Lively, T., Paik, S., Ellis, M. J., Abrams, J. & Sledge, G. W., Mar 2020, In : JAMA Oncology. 6, 3, p. 367-374 8 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

ERα-related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer

Lin, C. L., Tan, X., Chen, M., Kusi, M., Hung, C. N., Chou, C. W., Hsu, Y. T., Wang, C. M., Kirma, N., Chen, C. L., Lin, C. H., Lathrop, K. I., Elledge, R., Kaklamani, V. G., Mitsuya, K. & Huang, T. H. M., May 14 2020, In : BMC Medical Genomics. 13, 1, 69.

Research output: Contribution to journalArticle

Open Access

Everolimus inhibits the progression of ductal carcinoma in situ to invasive breast cancer via downregulation of MMP9 expression

Chen, G., Ding, X. F., Pressley, K., Bouamar, H., Wang, B., Zheng, G., Broome, L. E., Nazarullah, A., Brenner, A. J., Kaklamani, V., Jatoi, I. & Sun, L. Z., Mar 15 2020, In : Clinical Cancer Research. 26, 6, p. 1486-1496 11 p.

Research output: Contribution to journalArticle

Subtype-Guided 18F-FDG PET/CT in Tailoring Axillary Surgery Among Patients with Node-Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: A Feasibility Study

Wu, S., Wang, Y., Li, J., Zhang, N., Mo, M., Klimberg, S., Kaklamani, V., Cochet, A., Shao, Z., Cheng, J. & Liu, G., Apr 1 2020, In : Oncologist. 25, 4, p. e626-e633

Research output: Contribution to journalArticle

Open Access
2019

A randomized, controlled phase II trial of neoadjuvant ado-trastuzumab emtansine, lapatinib, and nab-paclitaxel versus trastuzumab, pertuzumab, and paclitaxel in HER2-positive breast cancer (TEAL study)

Patel, T. A., Ensor, J. E., Creamer, S. L., Boone, T., Rodriguez, A. A., Niravath, P. A., Darcourt, J. G., Meisel, J. L., Li, X., Zhao, J., Kuhn, J. G., Rosato, R. R., Qian, W., Belcheva, A., Schwartz, M. R., Kaklamani, V. G. & Chang, J. C., Sep 2 2019, In : Breast Cancer Research. 21, 1, 100.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Challenges for the clinical development of PI3K inhibitors: Strategies to improve their impact in solid tumors

Hanker, A. B., Kaklamani, V. & Arteaga, C. L., Apr 2019, In : Cancer Discovery. 9, 4, p. 482-491 10 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Clinical and genomic risk to guide the use of adjuvant therapy for breast cancer

Sparano, J. A., Gray, R. J., Ravdin, P. M., Makower, D. F., Pritchard, K. I., Albain, K. S., Hayes, D. F., Geyer, C. E., Dees, E. C., Goetz, M. P., Olson, J. A., Lively, T., Badve, S. S., Saphner, T. J., Wagner, L. I., Whelan, T. J., Ellis, M. J., Paik, S., Wood, W. C., Keane, M. M. & 10 others, Gomez Moreno, H. L., Reddy, P. S., Goggins, T. F., Mayer, I. A., Brufsky, A. M., Toppmeyer, D. L., Kaklamani, V. G., Berenberg, J. L., Abrams, J. & Sledge, G. W., Jun 20 2019, In : New England Journal of Medicine. 380, 25, p. 2395-2405 11 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations
Open Access
Open Access

EMERALD: Phase III trial of elacestrant (RAD1901) vs endocrine therapy for previously treated ER+ advanced breast cancer

Bardia, A., Aftimos, P., Bihani, T., Anderson-Villaluz, A. T., Jung, J., Conlan, M. G. & Kaklamani, V. G., Jan 1 2019, In : Future Oncology. 15, 28, p. 3209-3218 10 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations
Open Access

Evaluating the Effect of a Video Education Curriculum for First Time Breast Cancer Patients: a Prospective RCT Feasibility Study

Sulakvelidze, N., Burdick, B., Kaklamani, V., Tilton, K., Baker, K., Kim, J., Javid, S. & Gralow, J. R., Dec 1 2019, In : Journal of Cancer Education. 34, 6, p. 1234-1240 7 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies

Jiang, Y. Z., Ma, D., Suo, C., Shi, J., Xue, M., Hu, X., Xiao, Y., Yu, K. D., Liu, Y. R., Yu, Y., Zheng, Y., Li, X., Zhang, C., Hu, P., Zhang, J., Hua, Q., Zhang, J., Hou, W., Ren, L., Bao, D. & 23 others, Li, B., Yang, J., Yao, L., Zuo, W. J., Zhao, S., Gong, Y., Ren, Y. X., Zhao, Y. X., Yang, Y. S., Niu, Z., Cao, Z. G., Stover, D. G., Verschraegen, C., Kaklamani, V., Daemen, A., Benson, J. R., Takabe, K., Bai, F., Li, D. Q., Wang, P., Shi, L., Huang, W. & Shao, Z. M., Mar 18 2019, In : Cancer Cell. 35, 3, p. 428-440.e5

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Perspectives on the mechanism of action and clinical application of eribulin for metastatic breast cancer

O'Shaughnessy, J., Kaklamani, V. & Kalinsky, K., May 2019, In : Future Oncology. 15, 14, p. 1641-1653 13 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Use of Everolimus and Trastuzumab in Addition to Endocrine Therapy in Hormone-Refractory Metastatic Breast Cancer

Paplomata, E., Zelnak, A., Santa-Maria, C. A., Liu, Y., Gogineni, K., Li, X., Moreno, C. S., Chen, Z., Kaklamani, V. & O'Regan, R. M., Jun 2019, In : Clinical breast cancer. 19, 3, p. 188-196 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer

Sparano, J. A., Gray, R. J., Makower, D. F., Pritchard, K. I., Albain, K. S., Hayes, D. F., Geyer, C. E., Dees, E. C., Goetz, M. P., Olson, J. A., Lively, T., Badve, S. S., Saphner, T. J., Wagner, L. I., Whelan, T. J., Ellis, M. J., Paik, S., Wood, W. C., Ravdin, P. M., Keane, M. M. & 10 others, Gomez Moreno, H. L., Reddy, P. S., Goggins, T. F., Mayer, I. A., Brufsky, A. M., Toppmeyer, D. L., Kaklamani, V. G., Berenberg, J. L., Abrams, J. & Sledge, G. W., Jul 12 2018, In : New England Journal of Medicine. 379, 2, p. 111-121 11 p.

Research output: Contribution to journalArticle

445 Scopus citations

Empowering Latina breast cancer patients to make informed decisions about clinical trials: A pilot study

Chalela, P., Muñoz, E., Gallion, K. J., Kaklamani, V. & Ramirez, A. G., May 23 2018, In : Translational Behavioral Medicine. 8, 3, p. 439-449 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Improving adherence to endocrine hormonal therapy among breast cancer patients: Study protocol for a randomized controlled trial

Chalela, P., Munoz, E., Inupakutika, D., Kaghyan, S., Akopian, D., Kaklamani, V., Lathrop, K. & Ramirez, A., Dec 2018, In : Contemporary Clinical Trials Communications. 12, p. 109-115 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Multi-gene panel testing in breast cancer management

Fountzilas, C. & Kaklamani, V. G., Jan 1 2018, Cancer Treatment and Research. Springer International Publishing, p. 121-140 20 p. (Cancer Treatment and Research; vol. 173).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Tamoxifen resistance in breast cancer is regulated by the EZH2–ERa–GREB1 transcriptional axis

Wu, Y., Zhang, Z., Cenciarini, M. E., Proietti, C. J., Amasino, M., Hong, T., Yang, M., Liao, Y., Chiang, H. C., Kaklamani, V. G., Jeselsohn, R., Vadlamudi, R. K., Huang, T. H. M., Li, R., De Angelis, C., Fu, X., Elizalde, P. V., Schiff, R., Brown, M. & Xu, K., Feb 1 2018, In : Cancer Research. 78, 3, p. 671-684 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Unknown primary presenting with axillary Lymphadenopathy

Lathrop, K. I. & Kaklamani, V., Jan 1 2018, The Breast: Comprehensive Management of Benign and Malignant Diseases. Elsevier Inc., p. 1000-1003.e1

Research output: Chapter in Book/Report/Conference proceedingChapter

Veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in patients with BRCA1/2 locally recurrent/metastatic breast cancer: Randomized phase II study

Han, H. S., Diéras, V., Robson, M., Palácová, M., Marcom, P. K., Jager, A., Bondarenko, I., Citrin, D., Campone, M., Telli, M. L., Domchek, S. M., Friedlander, M., Kaufman, B., Garber, J. E., Shparyk, Y., Chmielowska, E., Jakobsen, E. H., Kaklamani, V., Gradishar, W., Ratajczak, C. K. & 6 others, Nickner, C., Qin, Q., Qian, J., Shepherd, S. P., Isakoff, S. J. & Puhalla, S., Jan 1 2018, In : Annals of Oncology. 29, 1, p. 154-161 8 p.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations
2017

A pilot study of cabergoline for the treatment of metastatic breast cancer

Costa, R., Santa-Maria, C. A., Scholtens, D. M., Jain, S., Flaum, L., Gradishar, W. J., Clevenger, C. V. & Kaklamani, V. G., Oct 1 2017, In : Breast Cancer Research and Treatment. 165, 3, p. 585-592 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Clinical and genetic predictors of weight gain in patients diagnosed with breast cancer

Sadim, M., Xu, Y., Selig, K., Paulus, J., Uthe, R., Agarwl, S., Dubin, I., Oikonomopoulou, P., Zaichenko, L., Mccandlish, S. A., Horn, L. V., Mantzoros, C., Ankerst, D. P. & Kaklamani, V. G., 2017, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

3 Scopus citations

Correlating mammographic and pathologic findings in clinical decision support using natural language processing and data mining methods

Patel, T. A., Puppala, M., Ogunti, R. O., Ensor, J. E., He, T., Shewale, J. B., Ankerst, D. P., Kaklamani, V. G., Rodriguez, A. A., Wong, S. T. C. & Chang, J. C., Jan 1 2017, In : Cancer. 123, 1, p. 114-121 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
1 Scopus citations

Efficacy of a weight loss intervention for african American breast cancer survivors

Stolley, M., Sheean, P., Gerber, B., Arroyo, C., Schiffer, L., Banerjee, A., Visotcky, A., Fantuzzi, G., Strahan, D., Matthews, L., Dakers, R., Carridine-Andrews, C., Seligman, K., Springfield, S., Odoms-Young, A., Hong, S., Hoskins, K., Kaklamani, V. & Sharp, L., Aug 20 2017, In : Journal of Clinical Oncology. 35, 24, p. 2820-2828 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endocrine therapy in the current management of postmenopausal Estrogen receptor-positive metastatic breast cancer

Kaklamani, V. G. & Gradishar, W. J., May 2017, In : Oncologist. 22, 5, p. 507-517 11 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Evaluating the Role of Extended Aromatase Inhibitor Therapy in Early Hormone-Positive Breast Cancer

Vyas, O. H. & Kaklamani, V. G., Sep 1 2017, In : Current Breast Cancer Reports. 9, 3, p. 183-187 5 p.

Research output: Contribution to journalReview article

Outcomes in BRCA mutation carriers: Evaluation of current data for optimal clinical care

Vyas, O. H. & Kaklamani, V. G., Oct 1 2017, In : Translational Cancer Research. 6, p. S1269-S1272

Research output: Contribution to journalEditorial

Synergistic effect of eribulin and CDK inhibition for the treatment of triple negative breast cancer

Rao, S. S., Stoehr, J., Dokic, D., Wan, L., Decker, J. T., Konopka, K., Thomas, A. L., Wu, J., Kaklamani, V. G., Shea, L. D. & Jeruss, J. S., 2017, In : Oncotarget. 8, 48, p. 83925-83939 15 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2016

BRAF genomic alterations in breast cancer

Albanell, J., Elvin, J. A., Suh, J., Vergilio, J. A., Le, I. P., Kaklamani, V., Ali, S., Miller, V., Stephens, P., Gay, L. M. & Ross, J. S., Oct 1 2016, In : Annals of Oncology. 27, p. vi70

Research output: Contribution to journalArticle

Open Access
Open Access
6 Scopus citations

Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells

Liu, Z., Wang, L., Yang, J., Bandyopadhyay, A., Kaklamani, V., Wang, S. & Sun, L. Z., 2016, In : Oncotarget. 7, 26, p. 39097-39107 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Manic and nonadherent, with a diagnosis of breast cancer

Rahman, T., Kaklamani, V. & Frische, R., Jan 1 2016, In : Current Psychiatry. 15, 1, p. 51-57 7 p.

Research output: Contribution to journalArticle

2015

Adjuvant biologic agents for breast cancer

Kaklamani, V. G. & Gradishar, W. J., Jan 1 2015, Breast disease: Comprehensive management. Springer New York, p. 363-375 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

BRCA 1/2 gene mutation and gastrointestinal stromal tumours: A potential association

Waisbren, J., Uthe, R., Siziopikou, K. & Kaklamani, V., Jul 6 2015, In : BMJ case reports. 2015

Research output: Contribution to journalArticle

2 Scopus citations

Is the preoperative setting an appropriate platform for drug approval in breast cancer?

Kaklamani, V. G. & Gradishar, W. J., Nov 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 11, p. 1448-1452 5 p.

Research output: Contribution to journalArticle

Phase II neoadjuvant clinical trial of carboplatin and eribulin in women with triple negative early-stage breast cancer (NCT01372579)

Kaklamani, V. G., Jeruss, J. S., Hughes, E., Siziopikou, K., Timms, K. M., Gutin, A., Abkevich, V., Sangale, Z., Solimeno, C., Brown, K. L., Jones, J., Hartman, A. R., Meservey, C., Jovanovic, B., Helenowski, I., Khan, S. A., Bethke, K., Hansen, N., Uthe, R., Giordano, S. & 6 others, Rosen, S., Hoskins, K., Von Roenn, J., Jain, S., Parini, V. & Gradishar, W., Jun 4 2015, In : Breast Cancer Research and Treatment. 151, 3, p. 629-638 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Prospective validation of a 21-gene expression assay in breast cancer

Sparano, J. A., Gray, R. J., Makower, D. F., Pritchard, K. I., Albain, K. S., Hayes, D. F., Geyer, C. E., Dees, E. C., Perez, E. A., Olson, J. A., Zujewski, J. A., Lively, T., Badve, S. S., Saphner, T. J., Wagner, L. I., Whelan, T. J., Ellis, M. J., Paik, S., Wood, W. C., Ravdin, P. & 11 others, Keane, M. M., Gomez Moreno, H. L., Reddy, P. S., Goggins, T. F., Mayer, I. A., Brufsky, A. M., Toppmeyer, D. L., Kaklamani, V. G., Atkins, J. N., Berenberg, J. L. & Sledge, G. W., Nov 19 2015, In : New England Journal of Medicine. 373, 21, p. 2005-2014 10 p.

Research output: Contribution to journalArticle

Open Access
644 Scopus citations

Synchronous primary carcinoma of breast and ovary versus ovarian metastases

Yadav, B. S., Sharma, S. C., Robin, T. P., Sams, S., Elias, A. D., Kaklamani, V., Kelly Marcom, P., Schaefer, S. & Morris, G. J., Apr 1 2015, In : Seminars in Oncology. 42, 2, p. e13-e24

Research output: Contribution to journalReview article

2 Scopus citations
2014

Antipsychotic treatment in breast cancer patients

Rahman, T., Clevenger, C. V., Kaklamani, V., Lauriello, J., Campbell, A., Malwitz, K. & Kirkland, R. S., Jun 1 2014, In : American Journal of Psychiatry. 171, 6, p. 616-621 6 p.

Research output: Contribution to journalReview article

23 Scopus citations

Characteristics of individuals with breast cancer rearrangements in BRCA1 and BRCA2

Jackson, S. A., Davis, A. A., Li, J., Yi, N., McCormick, S. R., Grant, C., Fallen, T., Crawford, B., Loranger, K., Litton, J., Arun, B., Vande Wydeven, K., Sidani, A., Farmer, K., Sanders, M., Hoskins, K., Nussbaum, R., Esserman, L., Garber, J. E. & Kaklamani, V. G., May 15 2014, In : Cancer. 120, 10, p. 1557-1564 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genetic/familial high-risk assessment: Breast and ovarian, version 1.2014

Daly, M. B., Pilarski, R., Axilbund, J. E., Buys, S. S., Crawford, B., Friedman, S., Garber, J. E., Horton, C., Kaklamani, V., Klein, C., Kohlmann, W., Kurian, A., Litton, J., Madlensky, L., Marcom, P. K., Merajver, S. D., Offit, K., Pal, T., Pasche, B., Reiser, G. & 8 others, Shannon, K. M., Swisher, E., Voian, N. C., Weitzel, J. N., Whelan, A., Wiesner, G. L., Dwyer, M. A. & Kumar, R., Sep 1 2014, In : JNCCN Journal of the National Comprehensive Cancer Network. 12, 9, p. 1326-1338 13 p.

Research output: Contribution to journalArticle

Open Access
79 Scopus citations

Predicting benefit from imatinib: Are we close?

Gandhi, M. D. & Kaklamani, V. G., Nov 1 2014, In : Leukemia and Lymphoma. 55, 11, p. 2421-2422 2 p.

Research output: Contribution to journalComment/debate

Open Access

Preoperative Systemic Therapy for Breast Cancer

Kaklamani, V. & Gradishar, W. J., Jun 20 2014, Cancer Consult: Expertise for Clinical Practice. Wiley-Blackwell, p. 532-539 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yttrium-90 radioembolization stops progression of targeted breast cancer liver metastases after failed chemotherapy

Gordon, A. C., Gradishar, W. J., Kaklamani, V. G., Thuluvath, A. J., Ryu, R. K., Sato, K. T., Gates, V. L., Salem, R. & Lewandowski, R. J., Oct 1 2014, In : Journal of Vascular and Interventional Radiology. 25, 10, p. 1523-1532.e2

Research output: Contribution to journalArticle

34 Scopus citations
2013

Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative

Kaklamani, V. G., Hoffmann, T. J., Thornton, T. A., Hayes, G., Chlebowski, R., Van Horn, L. & Mantzoros, C., Jun 1 2013, In : Breast Cancer Research and Treatment. 139, 2, p. 461-468 8 p.

Research output: Contribution to journalArticle

17 Scopus citations