Sudha Seshadri

  • Source: Scopus
  • Calculated based on no. of publications stored in Pure and citations from Scopus
1989 …2021

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  • 2014

    Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy

    Westwoo, W., Beiser, A., DeCarli, C., Harris, T. B., Chen, T. C., He, X. M., Roubenoff, R., Pikula, A., Au, R., Braverman, L. E., Wolf, P. A., Vasan, R. S. & Seshadri, S., May 6 2014, In: Neurology. 82, 18, p. 1613-1619 7 p.

    Research output: Contribution to journalArticlepeer-review

    93 Scopus citations
  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

    NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), The Ashkenazi Jewish Dataset Investigator, Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC), Greek Parkinson’s Disease Consortium, Alzheimer Genetic Analysis Group, International Parkinson’s Disease Genomics Consortium (IPDGC), Parkinson’s Study Group (PSG) Parkinson’s Research: The Organized GENetics Initiative (PROGENI), 23andMe & GenePD, 2014, In: Nature Genetics. 46, 9, p. 989-993 5 p.

    Research output: Contribution to journalArticlepeer-review

    1011 Scopus citations
  • Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12

    Kilarski, L. L., Achterberg, S., Devan, W. J., Traylor, M., Malik, R., Lindgren, A., Pare, G., Sharma, P., Slowik, A., Thijs, V., Walters, M., Worrall, B. B., Sale, M. M., Algra, A., Kappelle, L. J., Wijmenga, C., Norrving, B., Sandling, J. K., Rönnblom, L., Goris, A. & 28 others, Franke, A., Sudlow, C., Rothwell, P. M., Levi, C., Holliday, E. G., Fornage, M., Psaty, B., Gretarsdottir, S., Thorsteinsdottir, U., Seshadri, S., Mitchell, B. D., Kittner, S., Clarke, R., Hopewell, J. C., Bis, J. C., Boncoraglio, G. B., Meschia, J., Ikram, M. A., Hansen, B. M., Montaner, J., Thorleifsson, G., Stefanson, K., Rosand, J., De Bakker, P. I. W., Farrall, M., Dichgans, M., Markus, H. S. & Bevan, S., Aug 19 2014, In: Neurology. 83, 8, p. 678-685 8 p.

    Research output: Contribution to journalArticlepeer-review

    69 Scopus citations
  • Midlife cardiovascular risk impacts executive function: Framingham offspring study

    Nishtala, A., Preis, S. R., Beiser, A., Devine, S., Hankee, L., Seshadri, S., Wolf, P. A. & Au, R., Jan 2014, In: Alzheimer Disease and Associated Disorders. 28, 1, p. 16-22 7 p.

    Research output: Contribution to journalArticlepeer-review

    23 Scopus citations
  • Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies

    Malik, R., Bevan, S., Nalls, M. A., Holliday, E. G., Devan, W. J., Cheng, Y. C., Ibrahim-Verbaas, C. A., Verhaaren, B. F. J., Bis, J. C., Joon, A. Y., De Stefano, A. L., Fornage, M., Psaty, B. M., Ikram, M. A., Launer, L. J., Van Duijn, C. M., Sharma, P., Mitchell, B. D., Rosand, J., Meschia, J. F. & 6 others, Levi, C., Rothwell, P. M., Sudlow, C., Markus, H. S., Seshadri, S. & Dichgans, M., Feb 2014, In: Stroke. 45, 2, p. 394-402 9 p.

    Research output: Contribution to journalArticlepeer-review

    40 Scopus citations
  • Mutation of FOXC and PITX induces cerebral small-vessel disease

    French, C. R., Seshadri, S., Destefano, A. L., Fornage, M., Arnold, C. R., Gage, P. J., Skarie, J. M., Dobyns, W. B., Millen, K. J., Liu, T., Dietz, W., Kume, T., Hofker, M., Emery, D. J., Childs, S. J., Waskiewicz, A. J. & Lehmann, O. J., Nov 3 2014, In: Journal of Clinical Investigation. 124, 11, p. 4877-4881 5 p.

    Research output: Contribution to journalArticlepeer-review

    58 Scopus citations
  • Parental longevity is associated with cognition and brain ageing in middle-aged offspring

    Murabito, J. M., Beiser, A. S., Decarli, C., Seshadri, S., Wolf, P. A. & Au, R., May 2014, In: Age and ageing. 43, 3, p. 358-363 6 p.

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations
  • Predicting stroke through genetic risk functions the CHARGE risk score project

    Ibrahim-Verbaas, C. A., Fornage, M., Bis, J. C., Choi, S. H., Psaty, B. M., Meigs, J. B., Rao, M., Nalls, M., Fontes, J. D., O'Donnell, C. J., Kathiresan, S., Ehret, G. B., Fox, C. S., Malik, R., Dichgans, M., Schmidt, H., Lahti, J., Heckbert, S. R., Lumley, T., Rice, K. & 25 others, Rotter, J. I., Taylor, K. D., Folsom, A. R., Boerwinkle, E., Rosamond, W. D., Shahar, E., Gottesman, R. F., Koudstaal, P. J., Amin, N., Wieberdink, R. G., Dehghan, A., Hofman, A., Uitterlinden, A. G., DeStefano, A. L., Debette, S., Xue, L., Beiser, A., Wolf, P. A., DeCarli, C., Ikram, M. A., Seshadri, S., Mosley, T. H., Longstreth, W. T., Van Duijn, C. M. & Launer, L. J., Feb 2014, In: Stroke. 45, 2, p. 403-412 10 p.

    Research output: Contribution to journalArticlepeer-review

    38 Scopus citations
  • Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the framingham heart study

    Romero, J. R., Preis, S. R., Beiser, A., Decarli, C., Viswanathan, A., Martinez-Ramirez, S., Kase, C. S., Wolf, P. A. & Seshadri, S., May 2014, In: Stroke. 45, 5, p. 1492-1494 3 p.

    Research output: Contribution to journalArticlepeer-review

    142 Scopus citations
  • Serum brain-derived neurotrophic factor and the risk for dementia: The framingham heart study

    Weinstein, G., Beiser, A. S., Choi, S. H., Preis, S. R., Chen, T. C., Vorgas, D., Au, R., Pikula, A., Wolf, P. A., DeStefano, A. L., Vasan, R. S. & Seshadri, S., Jan 2014, In: JAMA Neurology. 71, 1, p. 55-61 7 p.

    Research output: Contribution to journalArticlepeer-review

    133 Scopus citations
  • Shared genetic susceptibility to ischemic stroke and coronary artery disease: A genome-wide analysis of common variants

    Dichgans, M., Malik, R., König, I. R., Rosand, J., Clarke, R., Gretarsdottir, S., Thorleifsson, G., Mitchell, B. D., Assimes, T. L., Levi, C., Ódonnell, C. J., Fornage, M., Thorsteinsdottir, U., Psaty, B. M., Hengstenberg, C., Seshadri, S., Erdmann, J., Bis, J. C., Peters, A., Boncoraglio, G. B. & 19 others, März, W., Meschia, J. F., Kathiresan, S., Ikram, M. A., McPherson, R., Stefansson, K., Sudlow, C., Reilly, M. P., Thompson, J. R., Sharma, P., Hopewell, J. C., Chambers, J. C., Watkins, H., Rothwell, P. M., Roberts, R., Markus, H. S., Samani, N. J., Farrall, M. & Schunkert, H., Jan 2014, In: Stroke. 45, 1, p. 24-36 13 p.

    Research output: Contribution to journalArticlepeer-review

    210 Scopus citations
  • Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

    The NHLBI Grand Opportunity Exome Sequencing Project, Feb 6 2014, In: American Journal of Human Genetics. 94, 2, p. 233-245 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    152 Scopus citations
  • 2013

    APOE genotype modifies the relationship between midlife vascular risk factors and later cognitive decline

    Bangen, K. J., Beiser, A., Delano-Wood, L., Nation, D. A., Lamar, M., Libon, D. J., Bondi, M. W., Seshadri, S., Wolf, P. A. & Au, R., Nov 2013, In: Journal of Stroke and Cerebrovascular Diseases. 22, 8, p. 1361-1369 9 p.

    Research output: Contribution to journalArticlepeer-review

    68 Scopus citations
  • Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structure

    Zade, D., Beiser, A., McGlinchey, R., Au, R., Seshadri, S., Palumbo, C., Wolf, P. A., Decarli, C. & Milberg, W., Feb 2013, In: Journal of Stroke and Cerebrovascular Diseases. 22, 2, p. 119-125 7 p.

    Research output: Contribution to journalArticlepeer-review

    18 Scopus citations
  • Association of parental stroke with brain injury and cognitive measures in offspring: The Framingham heart study

    Weinstein, G., Beiser, A. S., Au, R., De Carli, C., Wolf, P. A. & Seshadri, S., Mar 2013, In: Stroke. 44, 3, p. 812-815 4 p.

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations
  • Brain imaging and cognitive predictors of stroke and alzheimer disease in the framingham heart study

    Weinstein, G., Beiser, A. S., Decarli, C., Au, R., Wolf, P. A. & Seshadri, S., Oct 2013, In: Stroke. 44, 10, p. 2787-2794 8 p.

    Research output: Contribution to journalArticlepeer-review

    37 Scopus citations
  • COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups

    Sachdev, P. S., Lipnicki, D. M., Kochan, N. A., Crawford, J. D., Rockwood, K., Xiao, S., Li, J., Li, X., Brayne, C., Matthews, F. E., Stephan, B. C. M., Lipton, R. B., Katz, M. J., Ritchie, K., Carrière, I., Ancelin, M. L., Seshadri, S., Au, R., Beiser, A. S., Lam, L. C. W. & 25 others, Wong, C. H. Y., Fung, A. W. T., Kim, K. W., Han, J. W., Kim, T. H., Petersen, R. C., Roberts, R. O., Mielke, M. M., Ganguli, M., Dodge, H. H., Hughes, T., Anstey, K. J., Cherbuin, N., Butterworth, P., Ng, T. P., Gao, Q., Reppermund, S., Brodaty, H., Meguro, K., Schupf, N., Manly, J., Stern, Y., Lobo, A., Lopez-Anton, R. & Santabárbara, J., Nov 6 2013, In: BMC Neurology. 13, 165.

    Research output: Contribution to journalArticlepeer-review

    36 Scopus citations
  • Defining MCI in the framingham heart study offspring: Education versus WRAT-based norms

    Ahl, R. E., Beiser, A., Seshadri, S., Auerbach, S., Wolf, P. A. & Au, R., Oct 2013, In: Alzheimer Disease and Associated Disorders. 27, 4, p. 330-336 7 p.

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations
  • Ischemic stroke is associated with the ABO locus: the EuroCLOT study.

    Williams, F. M. K., Carter, A. M., Hysi, P. G., Surdulescu, G., Hodgkiss, D., Soranzo, N., Traylor, M., Bevan, S., Dichgans, M., Rothwell, P. M. W., Sudlow, C., Farrall, M., Silander, K., Kaunisto, M., Wagner, P., Saarela, O., Kuulasmaa, K., Virtamo, J., Salomaa, V., Amouyel, P. & 43 others, Arveiler, D., Ferrieres, J., Wiklund, P. G., Ikram, M. A., Hofman, A., Boncoraglio, G. B., Parati, E. A., Helgadottir, A., Gretarsdottir, S., Thorsteinsdottir, U., Thorleifsson, G., Stefansson, K., Seshadri, S., DeStefano, A., Gschwendtner, A., Psaty, B., Longstreth, W., Mitchell, B. D., Cheng, Y. C., Clarke, R., Ferrario, M., Bis, J. C., Levi, C., Attia, J., Holliday, E. G., Scott, R. J., Fornage, M., Sharma, P., Furie, K. L., Rosand, J., Nalls, M., Meschia, J., Mosely, T. H., Evans, A., Palotie, A., Markus, H. S., Grant, P. J., Spector, T. D., EuroCLOT Investigators, I., Wellcome Trust Case Control Consortium 2, T. C. C. C. ., MOnica Risk, Genetics, Archiving, R. G. A., MetaStroke & International Stroke Genetics Consortium, S. G. C., Jan 2013, In: Unknown Journal. 73, 1, p. 16-31 16 p.

    Research output: Contribution to journalArticlepeer-review

    92 Scopus citations
  • Lexical retrieval in discourse: An early indicator of Alzheimer's dementia

    Pekkala, S., Wiener, D., Himali, J. J., Beiser, A. S., Obler, L. K., Liu, Y., McKee, A., Auerbach, S., Seshadri, S., Wolf, P. A. & Au, R., 2013, In: Clinical Linguistics and Phonetics. 27, 12, p. 905-921 17 p.

    Research output: Contribution to journalArticlepeer-review

    17 Scopus citations
  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Lambert, J. C., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., Jun, G., DeStefano, A. L., Bis, J. C., Beecham, G. W., Grenier-Boley, B., Russo, G., Thornton-Wells, T. A., Jones, N., Smith, A. V., Chouraki, V., Thomas, C., Ikram, M. A., Zelenika, D., Vardarajan, B. N. & 162 others, Kamatani, Y., Lin, C. F., Gerrish, A., Schmidt, H., Kunkle, B., Fiévet, N., Amouyel, P., Pasquier, F., Deramecourt, V., De Bruijn, R. F. A. G., Amin, N., Hofman, A., Van Duijn, C. M., Dunstan, M. L., Hollingworth, P., Owen, M. J., O'Donovan, M. C., Jones, L., Holmans, P. A., Moskvina, V., Williams, J., Baldwin, C., Farrer, L. A., Choi, S. H., Lunetta, K. L., Fitzpatrick, A. L., Harris, T. B., Psaty, B. M., Gilbert, J. R., Hamilton-Nelson, K. L., Martin, E. R., Pericak-Vance, M. A., Haines, J. L., Gudnason, V., Jonsson, P. V., Eiriksdottir, G., Bihoreau, M. T., Lathrop, M., Valladares, O., Cantwell, L. B., Wang, L. S., Schellenberg, G. D., Ruiz, A., Boada, M., Reitz, C., Mayeux, R., Ramirez, A., Maier, W., Hanon, O., Kukull, W. A., Buxbaum, J. D., Campion, D., Wallon, D., Hannequin, D., Crane, P. K., Larson, E. B., Becker, T., Cruchaga, C., Goate, A. M., Craig, D., Johnston, J. A., Mc-Guinness, B., Todd, S., Passmore, P., Berr, C., Ritchie, K., Lopez, O. L., De Jager, P. L., Evans, D., Lovestone, S., Proitsi, P., Powell, J. F., Letenneur, L., Barberger-Gateau, P., Dufouil, C., Dartigues, J. F., Morón, F. J., Rubinsztein, D. C., St. George-Hyslop, P., Sleegers, K., Bettens, K., Van Broeckhoven, C., Huentelman, M. J., Gill, M., Brown, K., Morgan, K., Kamboh, M. I., Keller, L., Fratiglioni, L., Green, R., Myers, A. J., Love, S., Rogaeva, E., Gallacher, J., Bayer, A., Clarimon, J., Lleo, A., Tsuang, D. W., Yu, L., Bennett, D. A., Tsolaki, M., Bossù, P., Spalletta, G., Collinge, J., Mead, S., Sorbi, S., Nacmias, B., Sanchez-Garcia, F., Deniz Naranjo, M. C., Fox, N. C., Hardy, J., Bosco, P., Clarke, R., Brayne, C., Galimberti, D., Mancuso, M., Matthews, F., Moebus, S., Mecocci, P., Del Zompo, M., Hampel, H., Pilotto, A., Bullido, M., Panza, F., Caffarra, P., Mayhaus, M., Pichler, S., Gu, W., Riemenschneider, M., Lannfelt, L., Ingelsson, M., Hakonarson, H., Carrasquillo, M. M., Zou, F., Younkin, S. G., Beekly, D., Alvarez, V., Coto, E., Razquin, C., Pastor, P., Mateo, I., Combarros, O., Faber, K. M., Foroud, T. M., Soininen, H., Hiltunen, M., Blacker, D., Mosley, T. H., Graff, C., Holmes, C., Montine, T. J., Rotter, J. I., Brice, A., Nalls, M. A., Kauwe, J. S. K., Boerwinkle, E., Schmidt, R., Rujescu, D., Tzourio, C., Nöthen, M. M., Launer, L. J. & Seshadri, S., Dec 1 2013, In: Nature Genetics. 45, 12, p. 1452-1458 7 p.

    Research output: Contribution to journalArticlepeer-review

    2116 Scopus citations
  • Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

    Sabater-Lleal, M., Huang, J., Chasman, D., Naitza, S., Dehghan, A., Johnson, A. D., Teumer, A., Reiner, A. P., Folkersen, L., Basu, S., Rudnicka, A. R., Trompet, S., Mälarstig, A., Baumert, J., Bis, J. C., Guo, X., Hottenga, J. J., Shin, S. Y., Lopez, L. M., Lahti, J. & 125 others, Tanaka, T., Yanek, L. R., Oudot-Mellakh, T., Wilson, J. F., Navarro, P., Huffman, J. E., Zemunik, T., Redline, S., Mehra, R., Pulanic, D., Rudan, I., Wright, A. F., Kolcic, I., Polasek, O., Wild, S. H., Campbell, H., Curb, J. D., Wallace, R., Liu, S., Eaton, C. B., Becker, D. M., Becker, L. C., Bandinelli, S., Räikkönen, K., Widen, E., Palotie, A., Fornage, M., Green, D., Gross, M., Davies, G., Harris, S. E., Liewald, D. C., Starr, J. M., Williams, F. M. K., Grant, P. J., Spector, T. D., Strawbridge, R. J., Silveira, A., Sennblad, B., Rivadeneira, F., Uitterlinden, A. G., Franco, O. H., Hofman, A., Van Dongen, J., Willemsen, G., Boomsma, D. I., Yao, J., Swords Jenny, N., Haritunians, T., McKnight, B., Lumley, T., Taylor, K. D., Rotter, J. I., Psaty, B. M., Peters, A., Gieger, C., Illig, T., Grotevendt, A., Homuth, G., Völzke, H., Kocher, T., Goel, A., Franzosi, M. G., Seedorf, U., Clarke, R., Steri, M., Tarasov, K. V., Sanna, S., Schlessinger, D., Stott, D. J., Sattar, N., Buckley, B. M., Rumley, A., Lowe, G. D., McArdle, W. L., Chen, M. H., Tofler, G. H., Song, J., Boerwinkle, E., Folsom, A. R., Rose, L. M., Franco-Cereceda, A., Teichert, M., Ikram, M. A., Mosley, T. H., Bevan, S., Dichgans, M., Rothwell, P. M., Sudlow, C. L. M., Hopewell, J. C., Chambers, J. C., Saleheen, D., Kooner, J. S., Danesh, J., Nelson, C. P., Erdmann, J., Reilly, M. P., Kathiresan, S., Schunkert, H., Morange, P. E., Ferrucci, L., Eriksson, J. G., Jacobs, D., Deary, I. J., Soranzo, N., Witteman, J. C. M., De Geus, E. J. C., Tracy, R. P., Hayward, C., Koenig, W., Cucca, F., Jukema, J. W., Eriksson, P., Seshadri, S., Markus, H. S., Watkins, H., Samani, N. J., Wallaschofski, H., Smith, N. L., Tregouet, D., Ridker, P. M., Tang, W., Strachan, D. P., Hamsten, A. & O'Donnell, C. J., Sep 17 2013, In: Circulation. 128, 12, p. 1310-1324 15 p.

    Research output: Contribution to journalArticlepeer-review

    95 Scopus citations
  • Qualitative neuropsychological measures: Normative data on executive functioning tests from the Framingham offspring study

    Hankee, L. D., Preis, S. R., Beiser, A. S., Devine, S. A., Liu, Y., Seshadri, S., Wolf, P. A. & Au, R., Oct 1 2013, In: Experimental Aging Research. 39, 5, p. 515-535 21 p.

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations
  • Relations of arterial stiffness and endothelial function to brain aging in the community

    Tsao, C. W., Seshadri, S., Beiser, A. S., Westwood, A. J., DeCarli, C., Au, R., Himali, J. J., Hamburg, N. M., Vita, J. A., Levy, D., Larson, M. G., Benjamin, E. J., Wolf, P. A., Vasan, R. S. & Mitchell, G. F., Sep 10 2013, In: Neurology. 81, 11, p. 984-991 8 p.

    Research output: Contribution to journalArticlepeer-review

    151 Scopus citations
  • Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury framingham study

    Pikula, A., Beiser, A. S., Chen, T. C., Preis, S. R., Vorgias, D., Decarli, C., Au, R., Kelly-Hayes, M., Kase, C. S., Wolf, P. A., Vasan, R. S. & Seshadri, S., Oct 2013, In: Stroke. 44, 10, p. 2768-2775 8 p.

    Research output: Contribution to journalArticlepeer-review

    92 Scopus citations
  • The framingham heart study clock drawing performance: Normative data from the offspring Cohort

    Nyborn, J. A., Himali, J. J., Beiser, A. S., Devine, S. A., Du, Y., Kaplan, E., O'Connor, M. K., Rinn, W. E., Denison, H. S., Seshadri, S., Wolf, P. A. & Au, R., Jan 1 2013, In: Experimental Aging Research. 39, 1, p. 80-108 29 p.

    Research output: Contribution to journalArticlepeer-review

    16 Scopus citations
  • Transient global amnesia and neurological events: The framingham heart study

    Romero, J. R., Mercado, M., Beiser, A. S., Pikula, A., Seshadri, S., Kelly-Hayes, M., Wolf, P. A. & Kase, C. S., 2013, In: Frontiers in Neurology. 4 MAY, 47.

    Research output: Contribution to journalArticlepeer-review

    16 Scopus citations
  • Vitamin D concentration and lateral cerebral ventricle volume in older adults

    Annweiler, C., Montero-Odasso, M., Hachinski, V., Seshadri, S., Bartha, R. & Beauchet, O., Feb 2013, In: Molecular Nutrition and Food Research. 57, 2, p. 267-276 10 p.

    Research output: Contribution to journalArticlepeer-review

    53 Scopus citations
  • 2012

    Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: A one year prospective study in Taiwan

    Hsieh, Y. C., Seshadri, S., Chung, W. T., Hsieh, F. I., Hsu, Y. H., Lin, H. J., Tseng, H. P., Lien, L. M., Bai, C. H., Hu, C. J., Jeng, J. S., Tang, S. C., Chen, C. I., Yu, C. C. & Chiou, H. Y., 2012, In: Journal of Biomedical Science. 19, 1, 1.

    Research output: Contribution to journalArticlepeer-review

    27 Scopus citations
  • Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and Alzheimer disease: Results from the Framingham Heart Study

    Van Himbergen, T. M., Beiser, A. S., Ai, M., Seshadri, S., Otokozawa, S., Au, R., Thongtang, N., Wolf, P. A. & Schaefer, E. J., May 2012, In: Archives of Neurology. 69, 5, p. 594-600 7 p.

    Research output: Contribution to journalArticlepeer-review

    136 Scopus citations
  • Common variants at 12q14 and 12q24 are associated with hippocampal volume

    Bis, J. C., Decarli, C., Smith, A. V., Van Der Lijn, F., Crivello, F., Fornage, M., Debette, S., Shulman, J. M., Schmidt, H., Srikanth, V., Schuur, M., Yu, L., Choi, S. H., Sigurdsson, S., Verhaaren, B. F. J., Destefano, A. L., Lambert, J. C., Jack, C. R., Struchalin, M., Stankovich, J. & 62 others, Ibrahim-Verbaas, C. A., Fleischman, D., Zijdenbos, A., Den Heijer, T., Mazoyer, B., Coker, L. H., Enzinger, C., Danoy, P., Amin, N., Arfanakis, K., Van Buchem, M. A., De Bruijn, R. F. A. G., Beiser, A., Dufouil, C., Huang, J., Cavalieri, M., Thomson, R., Niessen, W. J., Chibnik, L. B., Gislason, G. K., Hofman, A., Pikula, A., Amouyel, P., Freeman, K. B., Phan, T. G., Oostra, B. A., Stein, J. L., Medland, S. E., Vasquez, A. A., Hibar, D. P., Wright, M. J., Franke, B., Martin, N. G., Thompson, P. M., Nalls, M. A., Uitterlinden, A. G., Au, R., Elbaz, A., Beare, R. J., Van Swieten, J. C., Lopez, O. L., Harris, T. B., Chouraki, V., Breteler, M. M. B., De Jager, P. L., Becker, J. T., Vernooij, M. W., Knopman, D., Fazekas, F., Wolf, P. A., Van Der Lugt, A., Gudnason, V., Longstreth, W. T., Brown, M. A., Bennett, D. A., Van Duijn, C. M., Mosley, T. H., Schmidt, R., Tzourio, C., Launer, L. J., Ikram, M. A. & Seshadri, S., May 2012, In: Nature Genetics. 44, 5, p. 545-551 7 p.

    Research output: Contribution to journalArticlepeer-review

    162 Scopus citations
  • Common variants at 6q22 and 17q21 are associated with intracranial volume

    Ikram, M. A., Fornage, M., Smith, A. V., Seshadri, S., Schmidt, R., Debette, S., Vrooman, H. A., Sigurdsson, S., Ropele, S., Taal, H. R., Mook-Kanamori, D. O., Coker, L. H., Longstreth, W. T., Niessen, W. J., Destefano, A. L., Beiser, A., Zijdenbos, A. P., Struchalin, M., Jack, C. R., Rivadeneira, F. & 109 others, Uitterlinden, A. G., Knopman, D. S., Hartikainen, A. L., Pennell, C. E., Thiering, E., Steegers, E. A. P., Hakonarson, H., Heinrich, J., Palmer, L. J., Jarvelin, M. R., Mccarthy, M. I., Grant, S. F. A., Pourcain, B. S., Timpson, N. J., Smith, G. D., Sovio, U., Nalls, M. A., Au, R., Hofman, A., Gudnason, H., Van Der Lugt, A., Harris, T. B., Meeks, W. M., Vernooij, M. W., Van Buchem, M. A., Catellier, D., Jaddoe, V. W. V., Gudnason, V., Windham, B. G., Wolf, P. A., Van Duijn, C. M., Mosley, T. H., Schmidt, H., Launer, L. J., Breteler, M. M. B., Decarli, C., Adair, L. S., Ang, W., Atalay, M., Van Beijsterveldt, T., Bergen, N., Benke, K., Berry, D., Coin, L., Davis, O. S. P., Elliott, P., Flexeder, C., Frayling, T., Gaillard, R., Groen-Blokhuis, M., Goh, L. K., Haworth, C. M. A., Hadley, D., Hedebrand, J., Hinney, A., Hirschhorn, J. N., Holloway, J. W., Holst, C., Jan Hottenga, J., Horikoshi, M., Huikari, V., Hypponen, E., Kilpeläinen, T. O., Kirin, M., Kowgier, M., Lakka, H. M., Lange, L. A., Lawlor, D. A., Lehtimäki, T., Lewin, A., Lindgren, C., Lindi, V., Maggi, R., Marsh, J., Middeldorp, C., Millwood, I., Murray, J. C., Nivard, M., Nohr, E. A., Ntalla, I., Oken, E., Panoutsopoulou, K., Pararajasingham, J., Rodriguez, A., Salem, R. M., Sebert, S., Siitonen, N., Strachan, D. P., Teo, Y. Y., Valcárcel, B., Willemsen, G., Zeggini, E., Boomsma, D. I., Cooper, C., Gillman, M., Hocher, B., Lakka, T. A., Mohlke, K. L., Dedoussis, G. V., Ong, K. K., Pearson, E. R., Price, T. S., Power, C., Raitakari, O. T., Saw, S. M., Scherag, A., Simell, O., Sørensen, T. I. A. & Wilson, J. F., May 2012, In: Nature Genetics. 44, 5, p. 539-544 6 p.

    Research output: Contribution to journalArticlepeer-review

    85 Scopus citations
  • Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: A cross-sectional study

    Maillard, P., Seshadri, S., Beiser, A., Himali, J. J., Au, R., Fletcher, E., Carmichael, O., Wolf, P. A. & DeCarli, C., Dec 2012, In: The Lancet Neurology. 11, 12, p. 1039-1047 9 p.

    Research output: Contribution to journalArticlepeer-review

    174 Scopus citations
  • Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): A meta-analysis of genome-wide association studies

    Traylor, M., Farrall, M., Holliday, E. G., Sudlow, C., Hopewell, J. C., Cheng, Y. C., Fornage, M., Ikram, M. A., Malik, R., Bevan, S., Thorsteinsdottir, U., Nalls, M. A., Longstreth, W. T., Wiggins, K. L., Yadav, S., Parati, E. A., DeStefano, A. L., Worrall, B. B., Kittner, S. J., Khan, M. S. & 62 others, Reiner, A. P., Helgadottir, A., Achterberg, S., Fernandez-Cadenas, I., Abboud, S., Schmidt, R., Walters, M., Chen, W. M., Ringelstein, E. B., O'Donnell, M., Ho, W. K., Pera, J., Lemmens, R., Norrving, B., Higgins, P., Benn, M., Sale, M., Kuhlenbäumer, G., Doney, A. S. F., Vicente, A. M., Delavaran, H., Algra, A., Davies, G., Oliveira, S. A., Palmer, C. N. A., Deary, I., Schmidt, H., Pandolfo, M., Montaner, J., Carty, C., de Bakker, P. I. W., Kostulas, K., Ferro, J. M., van Zuydam, N. R., Valdimarsson, E., Nordestgaard, B. G., Lindgren, A., Thijs, V., Slowik, A., Saleheen, D., Paré, G., Berger, K., Thorleifsson, G., Hofman, A., Mosley, T. H., Mitchell, B. D., Furie, K., Clarke, R., Levi, C., Seshadri, S., Gschwendtner, A., Boncoraglio, G. B., Sharma, P., Bis, J. C., Gretarsdottir, S., Psaty, B. M., Rothwell, P. M., Rosand, J., Meschia, J. F., Stefansson, K., Dichgans, M. & Markus, H. S., Nov 2012, In: The Lancet Neurology. 11, 11, p. 951-962 12 p.

    Research output: Contribution to journalArticlepeer-review

    326 Scopus citations
  • Identification of common variants associated with human hippocampal and intracranial volumes

    Stein, J. L., Medland, S. E., Vasquez, A. A., Hibar, D. P., Senstad, R. E., Winkler, A. M., Toro, R., Appel, K., Bartecek, R., Bergmann, Ø., Bernard, M., Brown, A. A., Cannon, D. M., Chakravarty, M. M., Christoforou, A., Domin, M., Grimm, O., Hollinshead, M., Holmes, A. J., Homuth, G. & 182 others, Hottenga, J. J., Langan, C., Lopez, L. M., Hansell, N. K., Hwang, K. S., Kim, S., Laje, G., Lee, P. H., Liu, X., Loth, E., Lourdusamy, A., Mattingsdal, M., Mohnke, S., Maniega, S. M., Nho, K., Nugent, A. C., O'brien, C., Papmeyer, M., Pütz, B., Ramasamy, A., Rasmussen, J., Rijpkema, M., Risacher, S. L., Roddey, J. C., Rose, E. J., Ryten, M., Shen, L., Sprooten, E., Strengman, E., Teumer, A., Trabzuni, D., Turner, J., Van Eijk, K., Van Erp, T. G. M., Van Tol, M. J., Wittfeld, K., Wolf, C., Woudstra, S., Aleman, A., Alhusaini, S., Almasy, L. A., Binder, E. B., Brohawn, D. G., Cantor, R. M., Carless, M. A., Corvin, A., Czisch, M., Curran, J. E., Davies, G., De Almeida, M. A. A., Delanty, N., Depondt, C., Duggirala, R., Dyer, T. D., Erk, S., Fagerness, J., Fox, P. T., Freimer, N. B., Gill, M., Goring, H. HH., Hagler, D. J., Hoehn, D., Holsboer, F., Hoogman, M., Hosten, N., Jahanshad, N., Johnson, M. P., Kasperaviciute, D., Kent, J. W., Kochunov, P., Lancaster, J. L., Lawrie, S. M., Liewald, D. C., Mandl, R., Matarin, M., Mattheisen, M., Meisenzahl, E., Melle, I., Moses, E. K., Mühleisen, T. W., Nauck, M., Nöthen, M. M., Olvera, R. L., Pandolfo, M., Pike, G. B., Puls, R., Reinvang, I., Rentería, M. E., Rietschel, M., Roffman, J. L., Royle, N. A., Rujescu, D., Savitz, J., Schnack, H. G., Schnell, K., Seiferth, N., Smith, C., Steen, V. M., Hernández, M. C. V., Van Den Heuvel, M., Van Der Wee, N. J., Van Haren, N. E. M., Veltman, J. A., Völzke, H., Walker, R., Westlye, L. T., Whelan, C. D., Agartz, I., Boomsma, D. I., Cavalleri, G. L., Dale, A. M., Djurovic, S., Drevets, W. C., Hagoort, P., Hall, J., Heinz, A., Jack, C. R., Foroud, T. M., Le Hellard, S., Macciardi, F., Montgomery, G. W., Poline, J. B., Porteous, D. J., Sisodiya, S. M., Starr, J. M., Sussmann, J., Toga, A. W., Veltman, D. J., Walter, H., Weiner, M. W., Bis, J. C., Ikram, M. A., Smith, A. V., Gudnason, V., Tzourio, C., Vernooij, M. W., Launer, L. J., Decarli, C., Seshadri, S., Andreassen, O. A., Apostolova, L. G., Bastin, M. E., Blangero, J. C., Brunner, H. G., Buckner, R. L., Cichon, S., Coppola, G., De Zubicaray, G. I., Deary, I. J., Donohoe, G., De Geus, E. J. C., Espeseth, T., Fernéndez, G., Glahn, D. C., Grabe, H. J., Hardy, J., Hulshoff Pol, H. E., Jenkinson, M., Kahn, R. S., Mcdonald, C., Mcintosh, A. M., Mcmahon, F. J., Mcmahon, K. L., Meyer-Lindenberg, A., Morris, D. W., Müller-Myhsok, B., Nichols, T. E., Ophoff, R. A., Paus, T., Pausova, Z., Penninx, B. W., Potkin, S. G., Sämann, P. G., Saykin, A. J., Schumann, G., Smoller, J. W., Wardlaw, J. M., Weale, M. E., Martin, N. G., Franke, B., Wright, M. J. & Thompson, P. M., May 2012, In: Nature Genetics. 44, 5, p. 552-561 10 p.

    Research output: Contribution to journalArticlepeer-review

    449 Scopus citations
  • Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early alzheimer disease pathology

    Kao, P. F., Banigan, M. G., Vanderburg, C. R., McKee, A. C., Polgar, P. R., Seshadri, S. & Delalle, I., Jul 2012, In: Journal of Neuropathology and Experimental Neurology. 71, 7, p. 654-664 11 p.

    Research output: Contribution to journalArticlepeer-review

    17 Scopus citations
  • Inverse association between cancer and Alzheimer's disease: Results from the Framingham Heart Study

    Driver, J. A., Beiser, A., Au, R., Kreger, B. E., Splansky, G. L., Kurth, T., Kiel, D. P., Lu, K. P., Seshadri, S. & Wolf, P. A., Mar 31 2012, In: BMJ (Online). 344, 7850, p. 19 1 p., e1442.

    Research output: Contribution to journalArticlepeer-review

    209 Scopus citations
  • Lipoprotein phospholipase A2 and cerebral microbleeds in the framingham heart study

    Romero, J. R., Preis, S. R., Beiser, A. S., Decarli, C., Lee, D. Y., Viswanathan, A., Benjamin, E. J., Fontes, J., Au, R., Pikula, A., Wang, J., Kase, C. S., Wolf, P. A., Irrizary, M. C. & Seshadri, S., Nov 2012, In: Stroke. 43, 11, p. 3091-3094 4 p.

    Research output: Contribution to journalArticlepeer-review

    27 Scopus citations
  • Multiple biomarkers and risk of clinical and subclinical vascular brain injury: The framingham offspring study

    Pikula, A., Beiser, A. S., Decarli, C., Himali, J. J., Debette, S., Au, R., Selhub, J., Toffler, G. H., Wang, T. J., Meigs, J. B., Kelly-Hayes, M., Kase, C. S., Wolf, P. A., Vasan, R. S. & Seshadri, S., May 1 2012, In: Circulation. 125, 17, p. 2100-2107 8 p.

    Research output: Contribution to journalArticlepeer-review

    46 Scopus citations
  • No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts

    Barral, S., Fernández-Cadenas, I., Bis, J. C., Montaner, J., Ikram, A. M., Launer, L. J., Fornage, M., Schmidt, H., Brickman, A. M., Seshadri, S. & Mayeux, R., Mar 2012, In: Neurobiology of Aging. 33, 3, p. 629.e1-629.e3

    Research output: Contribution to journalArticlepeer-review

    7 Scopus citations
  • Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging

    Tan, Z. S., Harris, W. S., Beiser, A. S., Au, R., Himali, J. J., Debette, S., Pikula, A., DeCarli, C., Wolf, P. A., Vasan, R. S., Robins, S. J. & Seshadri, S., Feb 28 2012, In: Neurology. 78, 9, p. 658-664 7 p.

    Research output: Contribution to journalArticlepeer-review

    167 Scopus citations
  • The framingham brain donation program: Neuropathology along the cognitive continuum

    Au, R., Seshadri, S., Knox, K., Beiser, A., Himali, J. J., Cabral, H. J., Auerbach, S., Green, R. C., Wolf, P. A. & Mckee, A. C., Jul 2012, In: Current Alzheimer Research. 9, 6, p. 673-686 14 p.

    Research output: Contribution to journalArticlepeer-review

    30 Scopus citations
  • Using Family-Based Imputation in Genome-Wide Association Studies with Large Complex Pedigrees: The Framingham Heart Study

    Chen, M. H., Huang, J., Chen, W. M., Larson, M. G., Fox, C. S., Vasan, R. S., Seshadri, S., O'Donnell, C. J. & Yang, Q., Dec 17 2012, In: PloS one. 7, 12, e51589.

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations
  • δ-Catenin Is Genetically and Biologically Associated with Cortical Cataract and Future Alzheimer-Related Structural and Functional Brain Changes

    Jun, G., Moncaster, J. A., Koutras, C., Seshadri, S., Buros, J., McKee, A. C., Levesque, G., Wolf, P. A., St. George-Hyslop, P., Goldstein, L. E. & Farrer, L. A., Sep 11 2012, In: PloS one. 7, 9, e43728.

    Research output: Contribution to journalArticlepeer-review

    41 Scopus citations
  • 2011

    A genome-wide association study of aging

    Walter, S., Atzmon, G., Demerath, E. W., Garcia, M. E., Kaplan, R. C., Kumari, M., Lunetta, K. L., Milaneschi, Y., Tanaka, T., Tranah, G. J., Völker, U., Yu, L., Arnold, A., Benjamin, E. J., Biffar, R., Buchman, A. S., Boerwinkle, E., Couper, D., De Jager, P. L., Evans, D. A. & 32 others, Harris, T. B., Hoffmann, W., Hofman, A., Karasik, D., Kiel, D. P., Kocher, T., Kuningas, M., Launer, L. J., Lohman, K. K., Lutsey, P. L., Mackenbach, J., Marciante, K., Psaty, B. M., Reiman, E. M., Rotter, J. I., Seshadri, S., Shardell, M. D., Smith, A. V., van Duijn, C., Walston, J., Zillikens, M. C., Bandinelli, S., Baumeister, S. E., Bennett, D. A., Ferrucci, L., Gudnason, V., Kivimaki, M., Liu, Y., Murabito, J. M., Newman, A. B., Tiemeier, H. & Franceschini, N., Nov 2011, In: Neurobiology of Aging. 32, 11, p. 2109.e15-2109.e28

    Research output: Contribution to journalArticlepeer-review

    104 Scopus citations
  • Association of HSP70 and its co-chaperones with Alzheimer's disease

    Broer, L., Ikram, M. A., Schuur, M., Destefano, A. L., Bis, J. C., Liu, F., Rivadeneira, F., Uitterlinden, A. G., Beiser, A. S., Longstreth, W. T., Hofman, A., Aulchenko, Y., Seshadri, S., Fitzpatrick, A. L., Oostra, B. A., Breteler, M. M. B. & Van Duijn, C. M., 2011, In: Journal of Alzheimer's Disease. 25, 1, p. 93-102 10 p.

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations
  • Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: The Framingham offspring study

    Tan, Z. S., Beiser, A. S., Fox, C. S., Au, R., Himali, J. J., Debette, S., Decarli, C., Vasan, R. S., Wolf, P. A. & Seshadri, S., Aug 2011, In: Diabetes care. 34, 8, p. 1766-1770 5 p.

    Research output: Contribution to journalArticlepeer-review

    83 Scopus citations
  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

    Hollingworth, P., Harold, D., Sims, R., Gerrish, A., Lambert, J. C., Carrasquillo, M. M., Abraham, R., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Jones, N., Stretton, A., Thomas, C., Richards, A., Ivanov, D., Widdowson, C., Chapman, J., Lovestone, S., Powell, J. & 152 others, Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., Smith, A. D., Beaumont, H., Warden, D., Wilcock, G., Love, S., Kehoe, P. G., Hooper, N. M., Vardy, E. R. L. C., Hardy, J., Mead, S., Fox, N. C., Rossor, M., Collinge, J., Maier, W., Jessen, F., Rüther, E., Schürmann, B., Heun, R., Kölsch, H., Van Den Bussche, H., Heuser, I., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Gallacher, J., Hüll, M., Rujescu, D., Giegling, I., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Sleegers, K., Bettens, K., Engelborghs, S., De Deyn, P. P., Van Broeckhoven, C., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Tsolaki, M., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K. H., Klopp, N., Wichmann, H. E., Pankratz, V. S., Sando, S. B., Aasly, J. O., Barcikowska, M., Wszolek, Z. K., Dickson, D. W., Graff-Radford, N. R., Petersen, R. C., Van Duijn, C. M., Breteler, M. M. B., Ikram, M. A., Destefano, A. L., Fitzpatrick, A. L., Lopez, O., Launer, L. J., Seshadri, S., Berr, C., Campion, D., Epelbaum, J., Dartigues, J. F., Tzourio, C., Alpérovitch, A., Lathrop, M., Feulner, T. M., Friedrich, P., Riehle, C., Krawczak, M., Schreiber, S., Mayhaus, M., Nicolhaus, S., Wagenpfeil, S., Steinberg, S., Stefansson, H., Stefansson, K., SnÆdal, J., Björnsson, S., Jonsson, P. V., Chouraki, V., Genier-Boley, B., Hiltunen, M., Soininen, H., Combarros, O., Zelenika, D., Delepine, M., Bullido, M. J., Pasquier, F., Mateo, I., Frank-Garcia, A., Porcellini, E., Hanon, O., Coto, E., Alvarez, V., Bosco, P., Siciliano, G., Mancuso, M., Panza, F., Solfrizzi, V., Nacmias, B., Sorbi, S., Bossù, P., Piccardi, P., Arosio, B., Annoni, G., Seripa, D., Pilotto, A., Scarpini, E., Galimberti, D., Brice, A., Hannequin, D., Licastro, F., Jones, L., Holmans, P. A., Jonsson, T., Riemenschneider, M., Morgan, K., Younkin, S. G., Owen, M. J., O'Donovan, M., Amouyel, P. & Williams, J., May 2011, In: Nature Genetics. 43, 5, p. 429-436 8 p.

    Research output: Contribution to journalArticlepeer-review

    1267 Scopus citations
  • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

    Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., Smith, A. V., Tobin, M. D., Verwoert, G. C., Hwang, S. J., Pihur, V., Vollenweider, P., O'Reilly, P. F., Amin, N., Bragg-Gresham, J. L., Teumer, A., Glazer, N. L., Launer, L., Zhao, J. H., Aulchenko, Y. & 326 others, Heath, S., Sober, S., Parsa, A., Luan, J., Arora, P., Dehghan, A., Zhang, F., Lucas, G., Hicks, A. A., Jackson, A. U., Peden, J. F., Tanaka, T., Wild, S. H., Rudan, I., Igl, W., Milaneschi, Y., Parker, A. N., Fava, C., Chambers, J. C., Fox, E. R., Kumari, M., Go, M. J., van der Harst, P., Kao, W. H. L., Sjögren, M., Vinay, D. G., Alexander, M., Tabara, Y., Shaw-Hawkins, S., Whincup, P. H., Liu, Y., Shi, G., Kuusisto, J., Tayo, B., Seielstad, M., Sim, X., Hoang Nguyen, K. D., Lehtimäki, T., Matullo, G., Wu, Y., Gaunt, T. R., Charlotte Onland-Moret, N., Cooper, M. N., Platou, C. G. P., Org, E., Hardy, R., Dahgam, S., Palmen, J., Vitart, V., Braund, P. S., Kuznetsova, T., Uiterwaal, C. 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    139 Scopus citations