Sudha Seshadri

  • Source: Scopus
  • Calculated based on no. of publications stored in Pure and citations from Scopus
1989 …2021

Research activity per year

If you made any changes in Pure these will be visible here soon.
Filter
Article

Search results

  • 2019

    Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts

    Weinstein, G., Davis-Plourde, K. L., Conner, S., Himali, J. J., Beiser, A. S., Lee, A., Rawlings, A. M., Sedaghat, S., Ding, J., Moshier, E., Van Duijn, C. M., Beeri, M. S., Selvin, E., Arfan Ikram, M., Launer, L. J., Haan, M. N. & Seshadri, S., Feb 2019, In: PloS one. 14, 2, e0212293.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    24 Scopus citations
  • Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects

    Mishra, A., Chauhan, G., Violleau, M. H., Vojinovic, D., Jian, X., Bis, J. C., Li, S., Saba, Y., Grenier-Boley, B., Yang, Q., Bartz, T. M., Hofer, E., Soumaré, A., Peng, F., Duperron, M. G., Foglio, M., Mosley, T. H., Schmidt, R., Psaty, B. M., Launer, L. J. & 14 others, Boerwinkle, E., Zhu, Y., Mazoyer, B., Lathrop, M., Bellenguez, C., Van Duijn, C. M., Arfan Ikram, M., Schmidt, H., Longstreth, W. T., Fornage, M., Seshadri, S., Joutel, A., Tzourio, C. & Debette, S., Apr 1 2019, In: Brain. 142, 4, p. 1009-1023 15 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    11 Scopus citations
  • Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study

    McGrath, E. R., Himali, J. J., Levy, D., Conner, S. C., Pase, M. P., Abraham, C. R., Courchesne, P., Satizabal, C. L., Vasan, R. S., Beiser, A. S. & Seshadri, S., Mar 2019, In: PloS one. 14, 3, e0213321.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    9 Scopus citations
  • Circulating IGFBP-2: a novel biomarker for incident dementia

    McGrath, E. R., Himali, J. J., Levy, D., Conner, S. C., DeCarli, C. S., Pase, M. P., Courchesne, P., Satizabal, C. L., Vasan, R. S., Beiser, A. S. & Seshadri, S., Sep 1 2019, In: Annals of Clinical and Translational Neurology. 6, 9, p. 1659-1670 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    6 Scopus citations
  • Circulating monocyte chemoattractant protein-1 and risk of stroke meta-analysis of population-based studies involving 17180 individuals

    Georgakis, M. K., Malik, R., Björkbacka, H., Pana, T. A., Demissie, S., Ayers, C., Elhadad, M. A., Fornage, M., Beiser, A. S., Benjamin, E. J., Matthijs Boekholdt, S., Engström, G., Herder, C., Hoogeveen, R. C., Koenig, W., Melander, O., Orho-Melander, M., Schiopu, A., Söderholm, M., Wareham, N. & 7 others, Ballantyne, C. M., Peters, A., Seshadri, S., Myint, P. K., Nilsson, J., De Lemos, J. A. & Dichgans, M., Sep 27 2019, In: Circulation research. 125, 8, p. 773-782 10 p.

    Research output: Contribution to journalArticlepeer-review

    18 Scopus citations
  • Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis

    Yakushiji, Y., Wilson, D., Ambler, G., Charidimou, A., Beiser, A., Van Buchem, M. A., Decarli, C., Ding, D., Gudnason, V., Hara, H., Imaizumi, T., Kohara, K., Kwon, H. M., Launer, L. J., Mok, V., Phan, T., Preis, S. R., Romero, J. R., Seshadri, S., Srikanth, V. & 7 others, Takashima, Y., Tsushima, Y., Wang, Z., Wolf, P. A., Xiong, Y., Yamaguchi, S. & Werring, D. J., Mar 5 2019, In: Neurology. 92, 10, p. E1086-E1097

    Research output: Contribution to journalArticlepeer-review

    19 Scopus citations
  • Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings

    Adams, H. H. H., Roshchupkin, G. V., DeCarli, C., Franke, B., Grabe, H. J., Habes, M., Jahanshad, N., Medland, S. E., Niessen, W., Satizabal, C. L., Schmidt, R., Seshadri, S., Teumer, A., Thompson, P. M., Vernooij, M. W., Wittfeld, K. & Ikram, M. A., Dec 2019, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 286-290 5 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease

    Baker, E., Sims, R., Leonenko, G., Frizzati, A., Harwood, J. C., Grozeva, D., Morgan, K., Passmore, P., Holmes, C., Powell, J., Brayne, C., Gill, M., Mead, S., Bossù, P., Spalletta, G., Goate, A. M., Cruchaga, C., Maier, W., Heun, R., Jessen, F. & 16 others, Peters, O., Dichgans, M., FröLich, L., Ramirez, A., Jones, L., Hardy, J., Ivanov, D., Hill, M., Holmans, P., Allen, N. D., Morgan, B. P., Seshadri, S., Schellenberg, G. D., Amouyel, P., Williams, J. & Escott-Price, V., Jul 1 2019, In: PloS one. 14, 7, e0218111.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    8 Scopus citations
  • Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

    Stroke Genetics Network (SiGN), International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer’s Disease Genetics Consortium (ADGC) & Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Jan 29 2019, In: Neurology. 92, 5, p. E486-E503

    Research output: Contribution to journalArticlepeer-review

    Open Access
    10 Scopus citations
  • Genetic architecture of subcortical brain structures in 38,851 individuals

    Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., Smith, A. V., Bis, J. C., Jian, X., Luciano, M., Hofer, E., Teumer, A., van der Lee, S. J., Yang, J., Yanek, L. R., Lee, T. V. & 269 others, Li, S., Hu, Y., Koh, J. Y., Eicher, J. D., Desrivières, S., Arias-Vasquez, A., Chauhan, G., Athanasiu, L., Rentería, M. E., Kim, S., Hoehn, D., Armstrong, N. J., Chen, Q., Holmes, A. J., den Braber, A., Kloszewska, I., Andersson, M., Espeseth, T., Grimm, O., Abramovic, L., Alhusaini, S., Milaneschi, Y., Papmeyer, M., Axelsson, T., Ehrlich, S., Roiz-Santiañez, R., Kraemer, B., Håberg, A. K., Jones, H. J., Pike, G. B., Stein, D. J., Stevens, A., Bralten, J., Vernooij, M. W., Harris, T. B., Filippi, I., Witte, A. V., Guadalupe, T., Wittfeld, K., Mosley, T. H., Becker, J. T., Doan, N. T., Hagenaars, S. P., Saba, Y., Cuellar-Partida, G., Amin, N., Hilal, S., Nho, K., Mirza-Schreiber, N., Arfanakis, K., Becker, D. M., Ames, D., Goldman, A. L., Lee, P. H., Boomsma, D. I., Lovestone, S., Giddaluru, S., Le Hellard, S., Mattheisen, M., Bohlken, M. M., Kasperaviciute, D., Schmaal, L., Lawrie, S. M., Agartz, I., Walton, E., Tordesillas-Gutierrez, D., Davies, G. E., Shin, J., Ipser, J. C., Vinke, L. N., Hoogman, M., Jia, T., Burkhardt, R., Klein, M., Crivello, F., Janowitz, D., Carmichael, O., Haukvik, U. K., Aribisala, B. S., Schmidt, H., Strike, L. T., Cheng, C. Y., Risacher, S. L., Pütz, B., Fleischman, D. A., Assareh, A. A., Mattay, V. S., Buckner, R. L., Mecocci, P., Dale, A. M., Cichon, S., Boks, M. P., Matarin, M., Penninx, B. W. J. H., Calhoun, V. D., Chakravarty, M. M., Marquand, A. F., Macare, C., Kharabian Masouleh, S., Oosterlaan, J., Amouyel, P., Hegenscheid, K., Rotter, J. I., Schork, A. J., Liewald, D. C. M., de Zubicaray, G. I., Wong, T. Y., Shen, L., Sämann, P. G., Brodaty, H., Roffman, J. L., de Geus, E. J. C., Tsolaki, M., Erk, S., van Eijk, K. R., Cavalleri, G. L., van der Wee, N. J. A., McIntosh, A. M., Gollub, R. L., Bulayeva, K. B., Bernard, M., Richards, J. S., Himali, J. J., Loeffler, M., Rommelse, N., Hoffmann, W., Westlye, L. T., Valdés Hernández, M. C., Hansell, N. K., van Erp, T. G. M., Wolf, C., Kwok, J. B. J., Vellas, B., Heinz, A., Olde Loohuis, L. M., Delanty, N., Ho, B. C., Ching, C. R. K., Shumskaya, E., Singh, B., Hofman, A., van der Meer, D., Homuth, G., Psaty, B. M., Bastin, M. E., Montgomery, G. W., Foroud, T. M., Reppermund, S., Hottenga, J. J., Simmons, A., Meyer-Lindenberg, A., Cahn, W., Whelan, C. D., van Donkelaar, M. M. J., Yang, Q., Hosten, N., Green, R. C., Thalamuthu, A., Mohnke, S., Hulshoff Pol, H. E., Lin, H., Jack, C. R., Schofield, P. R., Mühleisen, T. W., Maillard, P., Potkin, S. G., Wen, W., Fletcher, E., Toga, A. W., Gruber, O., Huentelman, M., Davey Smith, G., Launer, L. J., Nyberg, L., Jönsson, E. G., Crespo-Facorro, B., Koen, N., Greve, D. N., Uitterlinden, A. G., Weinberger, D. R., Steen, V. M., Fedko, I. O., Groenewold, N. A., Niessen, W. J., Toro, R., Tzourio, C., Longstreth, W. T., Ikram, M. K., Smoller, J. W., van Tol, M. J., Sussmann, J. E., Paus, T., Lemaître, H., Schroeter, M. L., Mazoyer, B., Andreassen, O. A., Holsboer, F., Depondt, C., Veltman, D. J., Turner, J. A., Pausova, Z., Schumann, G., van Rooij, D., Djurovic, S., Deary, I. J., McMahon, K. L., Müller-Myhsok, B., Brouwer, R. M., Soininen, H., Pandolfo, M., Wassink, T. H., Cheung, J. W., Wolfers, T., Martinot, J. L., Zwiers, M. P., Nauck, M., Melle, I., Martin, N. G., Kanai, R., Westman, E., Kahn, R. S., Sisodiya, S. M., White, T., Saremi, A., van Bokhoven, H., Brunner, H. G., Völzke, H., Wright, M. J., van ‘t Ent, D., Nöthen, M. M., Ophoff, R. A., Buitelaar, J. K., Fernández, G., Sachdev, P. S., Rietschel, M., van Haren, N. E. M., Fisher, S. E., Beiser, A. S., Francks, C., Saykin, A. J., Mather, K. A., Romanczuk-Seiferth, N., Hartman, C. A., DeStefano, A. L., Heslenfeld, D. J., Weiner, M. W., Walter, H., Hoekstra, P. J., Nyquist, P. A., Franke, B., Bennett, D. A., Grabe, H. J., Johnson, A. D., Chen, C., van Duijn, C. M., Lopez, O. L., Fornage, M., Wardlaw, J. M., Schmidt, R., DeCarli, C., De Jager, P. L., Villringer, A., Debette, S., Gudnason, V., Medland, S. E., Shulman, J. M., Thompson, P. M., Seshadri, S. & Ikram, M. A., Nov 1 2019, In: Nature Genetics. 51, 11, p. 1624-1636 13 p.

    Research output: Contribution to journalArticlepeer-review

    44 Scopus citations
  • Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

    Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Mar 1 2019, In: Nature Genetics. 51, 3, p. 414-430 17 p.

    Research output: Contribution to journalArticlepeer-review

    478 Scopus citations
  • Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment

    Nagtegaal, A. P., Broer, L., Zilhao, N. R., Jakobsdottir, J., Bishop, C. E., Brumat, M., Christiansen, M. W., Cocca, M., Gao, Y., Heard-Costa, N. L., Evans, D. S., Pankratz, N., Pratt, S. R., Price, T. R., Spankovich, C., Stimson, M. R., Valle, K., Vuckovic, D., Wells, H., Eiriksdottir, G. & 22 others, Fransen, E., Ikram, M. A., Li, C. M., Longstreth, W. T., Steves, C., Van Camp, G., Correa, A., Cruickshanks, K. J., Gasparini, P., Girotto, G., Kaplan, R. C., Nalls, M., Schweinfurth, J. M., Seshadri, S., Sotoodehnia, N., Tranah, G. J., Uitterlinden, A. G., Wilson, J. G., Gudnason, V., Hoffman, H. J., Williams, F. M. K. & Goedegebure, A., Dec 1 2019, In: Scientific reports. 9, 1, 15192.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    5 Scopus citations
  • Interrelations Between Arterial Stiffness, Target Organ Damage, and Cardiovascular Disease Outcomes

    Vasan, R. S., Short, M. I., Niiranen, T. J., Xanthakis, V., DeCarli, C., Cheng, S., Seshadri, S. & Mitchell, G. F., 2019, In: Journal of the American Heart Association. 8, 14, e012141.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    22 Scopus citations
  • Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts

    Conner, S. C., Benayoun, L., Himali, J. J., Adams, S. L., Yang, Q., DeCarli, C., Blusztajn, J. K., Beiser, A., Seshadri, S. & Delalle, I., 2019, In: Journal of Alzheimer's Disease. 68, 1, p. 357-365 9 p.

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations
  • Mid-life and late-life vascular risk factor burden and neuropathology in old age

    Conner, S. C., Pase, M. P., Carneiro, H., Raman, M. R., McKee, A. C., Alvarez, V. E., Walker, J. M., Satizabal, C. L., Himali, J. J., Stein, T. D., Beiser, A. & Seshadri, S., Dec 1 2019, In: Annals of Clinical and Translational Neurology. 6, 12, p. 2403-2412 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4 Scopus citations
  • Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham Study

    Weinstein, G., Davis-Plourde, K., Himali, J. J., Zelber-Sagi, S., Beiser, A. S. & Seshadri, S., Sep 1 2019, In: Liver International. 39, 9, p. 1713-1721 9 p.

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations
  • Omega-3 fatty acids and genome-wide interaction analyses reveal DPP10–pulmonary function association

    Xu, J., Gaddis, N. C., Bartz, T. M., Hou, R., Manichaikul, A. W., Pankratz, N., Smith, A. V., Sun, F., Terzikhan, N., Markunas, C. A., Patchen, B. K., Schu, M., Beydoun, M. A., Brusselle, G. G., Eiriksdottir, G., Zhou, X., Wood, A. C., Graff, M., Harris, T. B., Arfan Ikram, M. & 30 others, Jacobs, D. R., Launer, L. J., Lemaitre, R. N., O’Connor, G. T., Oelsner, E. C., Psaty, B. M., Vasan, R. S., Rohde, R. R., Rich, S. S., Rotter, J. I., Seshadri, S., Smith, L. J., Tiemeier, H., Tsai, M. Y., Uitterlinden, A. G., Saroja Voruganti, V., Xu, H., Zilhão, N. R., Fornage, M., Carola Zillikens, M., London, S. J., Graham Barr, R., Dupuis, J., Gharib, S. A., Gudnason, V., Lahousse, L., North, K. E., Steffen, L. M., Cassano, P. A. & Hancock, D. B., Mar 1 2019, In: American Journal of Respiratory and Critical Care Medicine. 199, 5, p. 631-642 12 p.

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations
  • Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

    Schmidt, A. F., Holmes, M. V., Preiss, D., Swerdlow, D. I., Denaxas, S., Fatemifar, G., Faraway, R., Finan, C., Valentine, D., Fairhurst-Hunter, Z., Hartwig, F. P., Horta, B. L., Hypponen, E., Power, C., Moldovan, M., Van Iperen, E., Hovingh, K., Demuth, I., Norman, K., Steinhagen-Thiessen, E. & 145 others, Demuth, J., Bertram, L., Lill, C. M., Coassin, S., Willeit, J., Kiechl, S., Willeit, K., Mason, D., Wright, J., Morris, R., Wanamethee, G., Whincup, P., Ben-Shlomo, Y., McLachlan, S., Price, J. F., Kivimaki, M., Welch, C., Sanchez-Galvez, A., Marques-Vidal, P., Nicolaides, A., Panayiotou, A. G., Onland-Moret, N. C., Van Der Schouw, Y. T., Matullo, G., Fiorito, G., Guarrera, S., Sacerdote, C., Wareham, N. J., Langenberg, C., Scott, R. A., Luan, JA., Bobak, M., Malyutina, S., Pajak, A., Kubinova, R., Tamosiunas, A., Pikhart, H., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Jess, T., Cooper, J., Humphries, S. E., Brilliant, M., Kitchner, T., Hakonarson, H., Carrell, D. S., McCarty, C. A., Lester, K. H., Larson, E. B., Crosslin, D. R., De Andrade, M., Roden, D. M., Denny, J. C., Carty, C., Hancock, S., Attia, J., Holliday, E., Scott, R., Schofield, P., O'Donnell, M., Yusuf, S., Chong, M., Pare, G., Van Der Harst, P., Said, M. A., Eppinga, R. N., Verweij, N., Snieder, H., Christen, T., Mook-Kanamori, D. O., Gustafsson, S., Lind, L., Ingelsson, E., Pazoki, R., Franco, O., Hofman, A., Uitterlinden, A., Dehghan, A., Teumer, A., Baumeister, S., Dörr, M., Lerch, M. M., Völker, U., Völzke, H., Ward, J., Pell, J. P., Meade, T., Christophersen, I. E., Maitland-Van Der Zee, A. H., Baranova, E. V., Young, R., Ford, I., Campbell, A., Padmanabhan, S., Bots, M. L., Grobbee, D. E., Froguel, P., Thuillier, D., Roussel, R., Bonnefond, A., Cariou, B., Smart, M., Bao, Y., Kumari, M., Mahajan, A., Hopewell, J. C., Seshadri, S., Dale, C., Costa, R. P. E., Ridker, P. M., Chasman, D. I., Reiner, A. P., Ritchie, M. D., Lange, L. A., Cornish, A. J., Dobbins, S. E., Hemminki, K., Kinnersley, B., Sanson, M., Labreche, K., Simon, M., Bondy, M., Law, P., Speedy, H., Allan, J., Li, N., Went, M., Weinhold, N., Morgan, G., Sonneveld, P., Nilsson, B., Goldschmidt, H., Sud, A., Engert, A., Hansson, M., Hemingway, H., Asselbergs, F. W., Patel, R. S., Keating, B. J., Sattar, N., Houlston, R., Casas, J. P. & Hingorani, A. D., 2019, In: BMC Cardiovascular Disorders. 19, 1, 240.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    2 Scopus citations
  • Physical inactivity, cardiometabolic disease, and risk of dementia: An individual-participant meta-analysis

    Kivimäki, M., Singh-Manoux, A., Pentti, J., Sabia, S., Nyberg, S. T., Alfredsson, L., Goldberg, M., Knutsson, A., Koskenvuo, M., Koskinen, A., Kouvonen, A., Nordin, M., Oksanen, T., Strandberg, T., Suominen, S. B., Theorell, T., Vahtera, J., Väänänen, A., Virtanen, M., Westerholm, P. & 9 others, Westerlund, H., Zins, M., Seshadri, S., Batty, G. D., Sipilä, P. N., Shipley, M. J., Lindbohm, J. V., Ferrie, J. E. & Jokela, M., 2019, In: BMJ (Online). 365, l1495.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    50 Scopus citations
  • Plasma total-tau as a biomarker of stroke risk in the community

    Pase, M. P., Himali, J. J., Aparicio, H. J., Romero, J. R., Satizabal, C. L., Maillard, P., DeCarli, C., Beiser, A. S. & Seshadri, S., Sep 2019, In: Annals of neurology. 86, 3, p. 463-467 5 p.

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations
  • Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project

    Alzheimer's Disease Sequencing Project (ADSP), Jul 2019, In: Genomics. 111, 4, p. 808-818 11 p.

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations
  • Self-reported physical activity and relations to growth and neurotrophic factors in diabetes mellitus: The framingham offspring study

    Spartano, N. L., Davis-Plourde, K. L., Himali, J. J., Murabito, J. M., Vasan, R. S., Beiser, A. S. & Seshadri, S., 2019, In: Journal of diabetes research. 2019, 2718465.

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations
  • Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study

    Larsson, S. C., Traylor, M., Burgess, S., Boncoraglio, G. B., Jern, C., Michaëlsson, K., Markus, H. S., Malik, R., Chauhan, G., Sargurupremraj, M., Okada, Y., Mishra, A., Rutten-Jacobs, L., Giese, A. K., Van Der Laan, S. W., Gretarsdottir, S., Anderson, C. D., Chong, M., Adams, H. H. H., Ago, T. & 237 others, Almgren, P., Amouyel, P., Ay, H., Bartz, R. M., Benavente, O. R., Bevan, S., Brown, R. D., Butterworth, A. S., Carrera, C., Carty, C. L., Chasman, D. I., Chen, W. M., Cole, J. W., Correa, A., Cotlarciuc, I., Cruchaga, C., Danesh, J., De Bakker, P. I. W., Destefano, A. L., Hoed, M. D., Duan, Q., Engelter, S. T., Falcone, G. J., Gottesman, R. F., Grewal, R. P., Gudnason, V., Gustafsson, S., Haessler, J., Harris, T. B., Hassan, A., Havulinna, A. S., Heckbert, S. R., Holliday, E. G., Howard, G., Hsu, F. C., Hyacinth, H. I., Ikram, M. A., Ingelsson, E., Irvin, M. R., Jian, X., Jiménez-Conde, J., Johnson, J. A., Jukema, J. W., Kanai, M., Keene, K. L., Kissela, B. M., Kleindorfer, D. O., Kooperberg, C., Kubo, M., Lange, L. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lee, J. M., Lemmens, R., Leys, D., Lewis, C. M., Lin, W. Y., Lindgren, A. G., Lorentzen, E., Magnusson, P. K., Maguire, J., Manichaikul, A., McArdle, P. F., Meschia, J. F., Mitchell, B. D., Mosley, T. H., Nalls, M. A., Ninomiya, T., O'Donnell, M. J., Psaty, B. M., Pulit, S. L., Rannikmäe, K., Reiner, A. P., Rexrode, K. M., Rice, K., Rich, S. S., Ridker, P. M., Rost, N. S., Rothwell, P. M., Rotter, J. I., Rundek, T., Sacco, R. L., Sakaue, S., Sale, M. M., Salomaa, V., Sapkota, B. R., Schmidt, R., Schmidt, C. O., Schminke, U., Sharma, P., Slowik, A., Sudlow, C. L. M., Tanislav, C., Tatlisumak, T., Taylor, K. D., Thijs, V. N. S., Thorleifsson, G., Thorsteinsdottir, U., Tiedt, S., Trompet, S., Tzourio, C., Van Duijn, C. M., Walters, M., Wareham, N. J., Wassertheil-Smoller, S., Wilson, J. G., Wiggins, K. L., Yang, Q., Yusuf, S., Amin, N., Aparicio, H. S., Arnett, D. K., Attia, J., Beiser, A. S., Berr, C., Buring, J. E., Bustamante, M., Caso, V., Cheng, Y. C., Choi, S. H., Chowhan, A., Cullell, N., Dartigues, J. F., Delavaran, H., Delgado, P., Dörr, M., Engström, G., Ford, I., Gurpreet, W. S., Hamsten, A., Heitsch, L., Hozawa, A., Ibanez, L., Ilinca, A., Ingelsson, M., Iwasaki, M., Jackson, R. D., Jood, K., Jousilahti, P., Kaffashian, S., Kalra, L., Kamouchi, M., Kitazono, T., Kjartansson, O., Kloss, M., Koudstaal, P. J., Krupinski, J., Labovitz, D. L., Laurie, C. C., Levi, C. R., Li, L., Lind, L., Lindgren, C. M., Lioutas, V., Liu, Y. M., Lopez, O. L., Makoto, H., Martinez-Majander, N., Matsuda, K., Minegishi, N., Montaner, J., Morris, A. P., Muiño, E., Müller-Nurasyid, M., Norrving, B., Ogishima, S., Parati, E. A., Peddareddygari, L. R., Pedersen, N. L., Pera, J., Perola, M., Pezzini, A., Pileggi, S., Rabionet, R., Riba-Llena, I., Ribasés, M., Romero, J. R., Roquer, J., Rudd, A. G., Sarin, A. P., Sarju, R., Sarnowski, C., Sasaki, M., Satizabal, C. L., Satoh, M., Sattar, N., Sawada, N., Sibolt, G., Sigurdsson, Á., Smith, A., Sobue, K., Soriano-Tárraga, C., Stanne, T., Stine, O. C., Stott, D. J., Strauch, K., Takai, T., Tanaka, H., Tanno, K., Teumer, A., Tomppo, L., Torres-Aguila, N. P., Touze, E., Tsugane, S., Uitterlinden, A. G., Valdimarsson, E. M., Van Der Lee, S. J., Völzke, H., Wakai, K., Weir, D., Williams, S. R., Wolfe, C. D. A., Wong, Q., Xu, H., Yamaji, T., Sanghera, D. K., Melander, O., Strbian, D., Fernandez-Cadenas, I., Longstreth, W. T., Rolfs, A., Hata, J., Woo, D., Rosand, J., Pare, G., Hopewell, J. C., Saleheen, D., Stefansson, K., Worrall, B. B., Kittner, S. J., Seshadri, S., Fornage, M., Howson, J. M. M., Kamatani, Y., Debette, S. & Dichgans, M., Feb 26 2019, In: Neurology. 92, 9, p. E944-E950

    Research output: Contribution to journalArticlepeer-review

    Open Access
    11 Scopus citations
  • Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study

    Aparicio, H. J., Himali, J. J., Satizabal, C. L., Pase, M. P., Romero, J. R., Kase, C. S., Beiser, A. S. & Seshadri, S., 2019, In: Stroke. 50, 6, p. 1558-1560 3 p.

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations
  • The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE)

    Wolters, F. J., Yang, Q., Biggs, M. L., Jakobsdottir, J., Li, S., Evans, D. S., Bis, J. C., Harris, T. B., Vasan, R. S., Zilhao, N. R., Ghanbari, M., Arfan Ikram, M., Launer, L., Psaty, B. M., Tranah, G. J., Kulminski, A. M., Gudnason, V. & Seshadri, S., Jul 1 2019, In: PloS one. 14, 7, e0219668.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    15 Scopus citations
  • Understanding the consequences of education inequality on cardiovascular disease: Mendelian randomisation study

    Carter, A. R., Gill, D., Davies, N. M., Taylor, A. E., Tillmann, T., Vaucher, J., Wootton, R. E., Munafò, M. R., Hemani, G., Malik, R., Seshadri, S., Woo, D., Burgess, S., Davey Smith, G., Holmes, M. V., Tzoulaki, I., Howe, L. D. & Dehghan, A., 2019, In: The BMJ. 365, l1855.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    41 Scopus citations
  • Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study

    Salinas, J., Lin, H., Aparico, H. J., Huan, T., Liu, C., Rong, J., Beiser, A., Himali, J. J., Freedman, J. E., Larson, M. G., Rosand, J., Soreq, H., Levy, D. & Seshadri, S., Aug 1 2019, In: PloS one. 14, 8, e0219261.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    9 Scopus citations
  • 2018

    Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits

    Huan, T., Chen, G., Liu, C., Bhattacharya, A., Rong, J., Chen, B. H., Seshadri, S., Tanriverdi, K., Freedman, J. E., Larson, M. G., Murabito, J. M. & Levy, D., Feb 1 2018, In: Aging cell. 17, 1, e12687.

    Research output: Contribution to journalArticlepeer-review

    53 Scopus citations
  • A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

    The CHARGE Neurology Working Group, The COGENT-Kidney Consortium, The GIANT consortium & Lifelines Cohort Study, Mar 1 2018, In: American Journal of Human Genetics. 102, 3, p. 375-400 26 p.

    Research output: Contribution to journalArticlepeer-review

    44 Scopus citations
  • Analysis of shared heritability in common disorders of the brain

    The Brainstorm Consortium, Jun 22 2018, In: Science. 360, 6395, 8757.

    Research output: Contribution to journalArticlepeer-review

    578 Scopus citations
  • APOE and the association of fatty acids with the risk of stroke, coronary heart disease, and mortality

    Satizabal, C. L., Samieri, C., Davis-Plourde, K. L., Voetsch, B., Aparicio, H. J., Pase, M. P., Romero, J. R., Helmer, C., Vasan, R. S., Kase, C. S., Debette, S., Beiser, A. S. & Seshadri, S., 2018, In: Stroke. 49, 12, p. 2822-2829 8 p.

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations
  • Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

    Tynkkynen, J., Chouraki, V., van der Lee, S. J., Hernesniemi, J., Yang, Q., Li, S., Beiser, A., Larson, M. G., Sääksjärvi, K., Shipley, M. J., Singh-Manoux, A., Gerszten, R. E., Wang, T. J., Havulinna, A. S., Würtz, P., Fischer, K., Demirkan, A., Ikram, M. A., Amin, N., Lehtimäki, T. & 11 others, Kähönen, M., Perola, M., Metspalu, A., Kangas, A. J., Soininen, P., Ala-Korpela, M., Vasan, R. S., Kivimäki, M., van Duijn, C. M., Seshadri, S. & Salomaa, V., Jun 2018, In: Alzheimer's and Dementia. 14, 6, p. 723-733 11 p.

    Research output: Contribution to journalArticlepeer-review

    58 Scopus citations
  • Association of nonalcoholic fatty liver disease with lower brain volume in healthy middle-aged adults in the Framingham Study

    Weinstein, G., Zelber-Sagi, S., Preis, S. R., Beiser, A. S., DeCarli, C., Speliotes, E. K., Satizabal, C. L., Vasan, R. S. & Seshadri, S., Jan 2018, In: JAMA Neurology. 75, 1, p. 97-104 8 p.

    Research output: Contribution to journalArticlepeer-review

    35 Scopus citations
  • Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk

    Olson, N. C., Raffield, L. M., Lange, L. A., Lange, E. M., Longstreth, W. T., Chauhan, G., Debette, S., Seshadri, S., Reiner, A. P. & Tracy, R. P., Jan 2018, In: Journal of Thrombosis and Haemostasis. 16, 1, p. 19-30 12 p.

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations
  • Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition

    Seiler, S., Fletcher, E., Hassan-Ali, K., Weinstein, M., Beiser, A., Himali, J. J., Satizabal, C. L., Seshadri, S., DeCarli, C. & Maillard, P., Dec 2018, In: Neurobiology of Aging. 72, p. 14-22 9 p.

    Research output: Contribution to journalArticlepeer-review

    16 Scopus citations
  • Circulating cortisol and cognitive and structural brain measures

    Echouffo-Tcheugui, J. B., Conner, S. C., Himali, J. J., Maillard, P., Decarli, C. S., Beiser, A. S., Vasan, R. S. & Seshadri, S., Nov 20 2018, In: Neurology. 91, 21, p. E1961-E1970

    Research output: Contribution to journalArticlepeer-review

    29 Scopus citations
  • Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

    van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., Melo van Lent, D., Tynkkynen, J., Fischer, K., Hernesniemi, J., Haller, T., Singh-Manoux, A., Verhoeven, A., Willemsen, G., de Leeuw, F. A., Wagner, H., van Dongen, J., Hertel, J., Budde, K., Willems van Dijk, K. & 28 others, Weinhold, L., Ikram, M. A., Pietzner, M., Perola, M., Wagner, M., Friedrich, N., Slagboom, P. E., Scheltens, P., Yang, Q., Gertzen, R. E., Egert, S., Li, S., Hankemeier, T., van Beijsterveldt, C. E. M., Vasan, R. S., Maier, W., Peeters, C. F. W., Jörgen Grabe, H., Ramirez, A., Seshadri, S., Metspalu, A., Kivimäki, M., Salomaa, V., Demirkan, A., Boomsma, D. I., van der Flier, W. M., Amin, N. & van Duijn, C. M., Jun 2018, In: Alzheimer's and Dementia. 14, 6, p. 707-722 16 p.

    Research output: Contribution to journalArticlepeer-review

    50 Scopus citations
  • Circulating vascular growth factors and magnetic resonance imaging markers of small vessel disease and atrophy in middle-aged adults

    Raman, M. R., Himali, J. J., Conner, S. C., DeCarli, C., Vasan, R. S., Beiser, A. S., Seshadri, S., Maillard, P. & Satizabal, C. L., 2018, In: Stroke. 49, 9, p. 2227-2229 3 p.

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations
  • Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1)

    for The International META-MICROBLEEDS Initiative, Jul 1 2018, In: International Journal of Stroke. 13, 5, p. 454-468 15 p.

    Research output: Contribution to journalArticlepeer-review

    39 Scopus citations
  • DNA methylation signatures of depressive symptoms in middle-aged and elderly persons: Meta-analysis of multiethnic epigenome-wide studies

    Jovanova, O. S., Nedeljkovic, I., Spieler, D., Walker, R. M., Liu, C., Luciano, M., Bressler, J., Brody, J., Drake, A. J., Evans, K. L., Gondalia, R., Kunze, S., Kuhnel, B., Lahti, J., Lemaitre, R. N., Marioni, R. E., Swenson, B., Himali, J. J., Wu, H., Li, Y. & 29 others, McRae, A. F., Russ, T. C., Stewart, J., Wang, Z., Zhang, G., Ladwig, K. H., Uitterlinden, A. G., Guo, X., Peters, A., Räikkönen, K., Starr, J. M., Waldenberger, M., Wray, N. R., Whitsel, E. A., Sotoodehnia, N., Seshadri, S., Porteous, D. J., Van Meurs, J., Mosley, T. H., McIntosh, A. M., Mendelson, M. M., Levy, D., Hou, L., Eriksson, J. G., Fornage, M., Deary, I. J., Baccarelli, A., Tiemeier, H. & Amin, N., Sep 2018, In: JAMA Psychiatry. 75, 9, p. 949-959 11 p.

    Research output: Contribution to journalArticlepeer-review

    36 Scopus citations
  • Exome chip analysis identifies low-frequency and rare variants in MRPL38 for white matter hyperintensities on brain magnetic resonance imaging

    neuroCHARGE Working Group, 2018, In: Stroke. 49, 8, p. 1812-1819 8 p.

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations
  • Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease

    ARUK Consortium, GERAD/PERADES, CHARGE, ADGC, EADI, International Genomics of Alzheimer's Project (IGAP), ARUK Consortium & GERAD/PERADES, CHARGE, ADGC, EADI, Jan 1 2018, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 595-598 4 p.

    Research output: Contribution to journalArticlepeer-review

  • Genetic Interaction with Plasma Lipids on Alzheimer's Disease in the Framingham Heart Study

    Peloso, G. M., Beiser, A. S., DeStefano, A. L. & Seshadri, S., 2018, In: Journal of Alzheimer's Disease. 66, 3, p. 1275-1282 8 p.

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations
  • Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke

    Cole, J. W., Xu, H., Ryan, K., Jaworek, T., Dueker, N., McArdle, P., Gaynor, B., Cheng, Y. C., O'Connell, J., Bevan, S., Malik, R., Ahmed, N. U., Amouyel, P., Anjum, S., Bis, J. C., Crosslin, D., Danesh, J., Engelter, S. T., Fornage, M., Frossard, P. & 58 others, Gieger, C., Giese, A. K., Grond-Ginsbach, C., Ho, W. K., Holliday, E., Hopewell, J., Hussain, M., Iqbal, W., Jabeen, S., Jannes, J., Kamal, A., Kamatani, Y., Kanse, S., Kloss, M., Lathrop, M., Leys, D., Lindgren, A., LongstrethJr, W. T., Mahmood, K., Meisinger, C., Metso, T. M., Mosley, T., Müller-Nurasyid, M., Norrving, B., Parati, E., Peters, A., Pezzini, A., Quereshi, I., Rasheed, A., Rauf, A., Salam, T., Shen, J., Slowik, A., Stanne, T., Strauch, K., Tatlisumak, T., Thijs, V. N., Tiedt, S., Traylor, M., Waldenberger, M., Walters, M., Zhao, W., Boncoraglio, G., Debette, S., Jern, C., Levi, C., Markus, H., Meschia, J., Rolfs, A., Rothwell, P., Saleheen, D., Seshadri, S., Sharma, P., Sudlow, C., Worrall, B., Stine, O. C., Kittner, S. J. & Mitchell, B. D., Nov 2018, In: PloS one. 13, 11, e0206554.

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations
  • Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project

    Blue, E. E., Bis, J. C., Dorschner, M. O., Tsuang, D. W., Barral, S. M., Beecham, G., Below, J. E., Bush, W. S., Butkiewicz, M., Cruchaga, C., Destefano, A., Farrer, L. A., Goate, A., Haines, J., Jaworski, J., Jun, G., Kunkle, B., Kuzma, A., Lee, J. J., Lunetta, K. L. & 22 others, Ma, Y., Martin, E., Naj, A., Nato, A. Q., Navas, P., Nguyen, H., Reitz, C., Reyes, D., Salerno, W., Schellenberg, G. D., Seshadri, S., Sohi, H., Thornton, T. A., Valadares, O., Van Duijn, C., Vardarajan, B. N., Wang, L. S., Boerwinkle, E., Dupuis, J., Pericak-Vance, M. A., Mayeux, R. & Wijsman, E. M., May 1 2018, In: Dementia and Geriatric Cognitive Disorders. 45, 1-2, p. 1-17 17 p.

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations
  • Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

    Vojinovic, D., Adams, H. H., Jian, X., Yang, Q., Smith, A. V., Bis, J. C., Teumer, A., Scholz, M., Armstrong, N. J., Hofer, E., Saba, Y., Luciano, M., Bernard, M., Trompet, S., Yang, J., Gillespie, N. A., van der Lee, S. J., Neumann, A., Ahmad, S., Andreassen, O. A. & 71 others, Ames, D., Amin, N., Arfanakis, K., Bastin, M. E., Becker, D. M., Beiser, A. S., Beyer, F., Brodaty, H., Bryan, R. N., Bülow, R., Dale, A. M., De Jager, P. L., Deary, I. J., DeCarli, C., Fleischman, D. A., Gottesman, R. F., van der Grond, J., Gudnason, V., Harris, T. B., Homuth, G., Knopman, D. S., Kwok, J. B., Lewis, C. E., Li, S., Loeffler, M., Lopez, O. L., Maillard, P., El Marroun, H., Mather, K. A., Mosley, T. H., Muetzel, R. L., Nauck, M., Nyquist, P. A., Panizzon, M. S., Pausova, Z., Psaty, B. M., Rice, K., Rotter, J. I., Royle, N., Satizabal, C. L., Schmidt, R., Schofield, P. R., Schreiner, P. J., Sidney, S., Stott, D. J., Thalamuthu, A., Uitterlinden, A. G., Valdés Hernández, M. C., Vernooij, M. W., Wen, W., White, T., Witte, A. V., Wittfeld, K., Wright, M. J., Yanek, L. R., Tiemeier, H., Kremen, W. S., Bennett, D. A., Jukema, J. W., Paus, T., Wardlaw, J. M., Schmidt, H., Sachdev, P. S., Villringer, A., Grabe, H. J., Longstreth, W. T., van Duijn, C. M., Launer, L. J., Seshadri, S., Ikram, M. A. & Fornage, M., Dec 1 2018, In: Nature communications. 9, 1, 3945.

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations
  • GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

    MEGASTROKE Consortium, Dec 1 2018, In: Nature communications. 9, 1, 5141.

    Research output: Contribution to journalArticlepeer-review

    36 Scopus citations
  • Immunohistochemical Analysis of Activin Receptor-Like Kinase 1 (ACVRL1/ALK1) Expression in the Rat and Human Hippocampus: Decline in CA3 during Progression of Alzheimer's Disease

    Adams, S. L., Benayoun, L., Tilton, K., Mellott, T. J., Seshadri, S., Blusztajn, J. K. & Delalle, I., 2018, In: Journal of Alzheimer's Disease. 63, 4, p. 1433-1443 11 p.

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations
  • Meta-analysis of epigenome-wide association studies of cognitive abilities

    Marioni, R. E., McRae, A. F., Bressler, J., Colicino, E., Hannon, E., Li, S., Prada, D., Smith, J. A., Trevisi, L., Tsai, P. C., Vojinovic, D., Simino, J., Levy, D., Liu, C., Mendelson, M., Satizabal, C. L., Yang, Q., Jhun, M. A., Kardia, S. L. R., Zhao, W. & 27 others, Bandinelli, S., Ferrucci, L., Hernandez, D. G., Singleton, A. B., Harris, S. E., Starr, J. M., Kiel, D. P., McLean, R. R., Just, A. C., Schwartz, J., Spiro, A., Vokonas, P., Amin, N., Ikram, M. A., Uitterlinden, A. G., van Meurs, J. B. J., Spector, T. D., Steves, C., Baccarelli, A. A., Bell, J. T., van Duijn, C. M., Fornage, M., Hsu, Y. H., Mill, J., Mosley, T. H., Seshadri, S. & Deary, I. J., Nov 1 2018, In: Molecular psychiatry. 23, 11, p. 2133-2144 12 p.

    Research output: Contribution to journalArticlepeer-review

    31 Scopus citations
  • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

    Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGAST ROKE Consortium, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STA RNET BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC) & METAST ROKE Consortium, Apr 1 2018, In: Nature Genetics. 50, 4, p. 524-537 14 p.

    Research output: Contribution to journalArticlepeer-review

    301 Scopus citations