• 1002 Citations
  • 19 h-Index
1994 …2020

Research output per year

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Research Output

  • 1002 Citations
  • 19 h-Index
  • 40 Article
  • 1 Review article
2020

Mobilization-based transplantation of young-donor hematopoietic stem cells extends lifespan in mice

Guderyon, M. J., Chen, C., Bhattacharjee, A., Ge, G., Fernandez, R. A., Gelfond, J. A. L., Gorena, K. M., Cheng, C. J., Li, Y., Nelson, J. F., Strong, R. J., Hornsby, P. J., Clark, R. A. & Li, S., Mar 1 2020, In : Aging cell. 19, 3, e13110.

Research output: Contribution to journalArticle

Open Access

Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson's Disease

Chen, C., Guderyon, M. J., Li, Y., Ge, G., Bhattacharjee, A., Ballard, C., He, Z., Masliah, E., Clark, R. A., O'Connor, J. C. & Li, S., Jun 12 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 83-98 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Lentiviral Infection of Mouse Bone Marrow Cells for Hematopoietic Stem Cell Transplantation

Chen, C., Guderyon, M. J., Ge, G., Clark, R. A. & Li, S., Jan 1 2019, In : Methods in molecular biology (Clifton, N.J.). 1919, p. 205-213 9 p.

Research output: Contribution to journalArticle

Paternal benzo[a]pyrene exposure alters the sperm DNA methylation levels of imprinting genes in F0 generation mice and their unexposed F1-2 male offspring

Zhang, W., Yang, J., Lv, Y., Li, S. & Qiang, M., Aug 2019, In : Chemosphere. 228, p. 586-594 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice

Chen, C., Li, X., Ge, G., Liu, J., Biju, K. C., Laing, S. D., Qian, Y., Ballard, C., He, Z., Masliah, E., Clark, R. A., O'Connor, J. C. & Li, S., Dec 1 2018, In : Scientific reports. 8, 1, 5460.

Research output: Contribution to journalArticle

10 Scopus citations

Progressively disrupted somatodendritic morphology in dopamine neurons in a mouse Parkinson's model

Lynch, W. B., Tschumi, C. W., Sharpe, A. L., Branch, S. Y., Chen, C., Ge, G., Li, S. & Beckstead, M. J., Dec 2018, In : Movement Disorders. 33, 12, p. 1928-1937 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Regulatable lentiviral hematopoietic stem cell gene therapy in a mouse model of Parkinson's disease

Ge, G., Chen, C., Guderyon, M. J., Liu, J., He, Z., Yu, Y., Clark, R. A. & Li, S., Jul 15 2018, In : Stem Cells and Development. 27, 14, p. 995-1005 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Behavioral phenotypes associated with MPTP induction of partial lesions in common marmosets (Callithrix jacchus)

Phillips, K. A., Ross, C. N., Spross, J., Cheng, C. J., Izquierdo, A., Biju, K. C., Chen, C., Li, S. & Tardif, S. D., May 15 2017, In : Behavioural Brain Research. 325, p. 51-62 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Chronic administration of Benzo(a)pyrene induces memory impairment and anxiety-like behavior and increases of NR2B DNA methylation

Zhang, W., Tian, F., Zheng, J., Li, S. & Qiang, M., Feb 1 2016, In : PLoS One. 11, 2, e0149574.

Research output: Contribution to journalArticle

13 Scopus citations

Dopaminergic neurons exhibit an age-dependent decline in electrophysiological parameters in the MitoPark mouse model of Parkinson’s disease

Branch, S. Y., Chen, C., Sharma, R. N., Lechleiter, J. D., Li, S. & Beckstead, M. J., Apr 6 2016, In : Journal of Neuroscience. 36, 14, p. 4026-4037 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Hematopoietic knockdown of PPARδ reduces atherosclerosis in LDLR-/- mice

Li, G., Chen, C., Laing, S. D., Ballard, C., Biju, K. C., Reddick, R. L., Clark, R. A. & Li, S., Jan 1 2016, In : Gene Therapy. 23, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Multimodal MRI evaluation of the mitopark mouse model of Parkinson's disease

Cong, L., Muir, E. R., Chen, C., Qian, Y., Liu, J., Biju, K. C., Clark, R. A., Li, S. & Duong, T. Q., Mar 2016, In : PloS one. 11, 3, e0151884.

Research output: Contribution to journalArticle

12 Scopus citations
2015
3 Scopus citations

Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function

Chen, G. F., Sudhahar, V., Youn, S. W., Das, A., Cho, J., Kamiya, T., Urao, N., McKinney, R. D., Surenkhuu, B., Hamakubo, T., Iwanari, H., Li, S., Christman, J. W., Shantikumar, S., Angelini, G. D., Emanueli, C., Ushio-Fukai, M. & Fukai, T., Oct 6 2015, In : Scientific reports. 5, 14780.

Research output: Contribution to journalArticle

34 Scopus citations
2013

Bone marrow-derived microglia-based neurturin delivery protects against dopaminergic neurodegeneration in a mouse model of Parkinson's disease

Biju, K. C., Santacruz, R. A., Chen, C., Zhou, Q., Yao, J., Rohrabaugh, S. L., Clark, R. A., Roberts, J. L., Phillips, K. A., Imam, S. Z. & Li, S., Feb 22 2013, In : Neuroscience Letters. 535, 1, p. 24-29 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cognitive Dysfunction Precedes the Onset of Motor Symptoms in the MitoPark Mouse Model of Parkinson's Disease

Li, X., Redus, L., Chen, C., Martinez, P. A., Strong, R., Li, S. & O'Connor, J. C., Aug 15 2013, In : PloS one. 8, 8, e71341.

Research output: Contribution to journalArticle

32 Scopus citations

HSCARG Inhibits NADPH Oxidase Activity through Regulation of the Expression of p47phox

Xiao, W., Peng, Y., Liu, Y., Li, Z., Li, S. & Zheng, X., Mar 19 2013, In : PloS one. 8, 3, e59301.

Research output: Contribution to journalArticle

6 Scopus citations

Neuroprotective Efficacy of a New Brain-Penetrating C-Abl Inhibitor in a Murine Parkinson's Disease Model

Imam, S. Z., Trickler, W., Kimura, S., Binienda, Z. K., Paule, M. G., Slikker, W., Li, S., Clark, R. A. & Ali, S. F., May 31 2013, In : PloS one. 8, 5, e65129.

Research output: Contribution to journalArticle

39 Scopus citations

The nuclear receptor LXRα controls the functional specialization of splenic macrophages

A-Gonzalez, N., Guillen, J. A., Gallardo, G., Diaz, M., De La Rosa, J. V., Hernandez, I. H., Casanova-Acebes, M., Lopez, F., Tabraue, C., Beceiro, S., Hong, C., Lara, P. C., Andujar, M., Arai, S., Miyazaki, T., Li, S., Corbi, A. L., Tontonoz, P., Hidalgo, A. & Castrillo, A., Aug 2013, In : Nature Immunology. 14, 8, p. 831-839 9 p.

Research output: Contribution to journalArticle

86 Scopus citations
2012

Evaluation of macrophage-specific promoters using lentiviral delivery in mice

Levin, M. C., Lidberg, U., Jirholt, P., Adiels, M., Wramstedt, A., Gustafsson, K., Greaves, D. R., Li, S., Fazio, S., Linton, M. F., Olofsson, S. O., Borén, J. & Gjertsson, I., Nov 1 2012, In : Gene Therapy. 19, 11, p. 1041-1047 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Macrophage LXRα gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR/mice

Li, G., Biju, K. C., Xu, X., Zhou, Q., Chen, C., Valente, A. J., He, W., Reddick, R. L., Freeman, G. L., Ahuja, S. S., Clark, R. A. & Li, S., Aug 1 2011, In : Gene Therapy. 18, 8, p. 835-841 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Novel regulation of Parkin function through c-Abl-mediated tyrosine phosphorylation: Implications for Parkinson's disease

Imam, S. Z., Zhou, Q., Yamamoto, A., Valente, A. J., Ali, S. F., Bains, M., Roberts, J. L., Kahle, P. J., Clark, R. A. & Li, S., Jan 5 2011, In : Journal of Neuroscience. 31, 1, p. 157-163 7 p.

Research output: Contribution to journalArticle

104 Scopus citations
2010

Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: A therapeutic strategy for parkinson's disease

Biju, K., Zhou, Q., Li, G., Imam, S. Z., Roberts, J. L., Morgan, W. W., Clark, R. A. & Li, S., Aug 2010, In : Molecular Therapy. 18, 8, p. 1536-1544 9 p.

Research output: Contribution to journalArticle

73 Scopus citations
2008

Regulation of NOX1 expression by GATA, HNF-1α, and Cdx transcription factors

Valente, A. J., Zhou, Q., Lu, Z., He, W., Qiang, M., Ma, W., Li, G., Wang, L., Banfi, B., Steger, K., Krause, K. H., Clark, R. A. & Li, S., Feb 1 2008, In : Free Radical Biology and Medicine. 44, 3, p. 430-443 14 p.

Research output: Contribution to journalArticle

22 Scopus citations
2007

Development of a synthetic promoter for macrophage gene therapy

He, W., Qiang, M., Ma, W., Valente, A. J., Quinones, M. P., Wang, W., Reddick, R. L., Xiao, Q., Ahuja, S. S., Clark, R. A., Freeman, G. L. & Li, S., Jul 1 2007, In : Genetic Engineering and Biotechnology News. 27, SUPPL., p. 27-34 8 p.

Research output: Contribution to journalReview article

2006

Development of a synthetic promoter for macrophage gene therapy

He, W., Qiang, M., Ma, W., Valente, A. J., Quinones, M. P., Wang, W., Reddick, R. L., Xiao, Q., Ahuja, S. S., Clark, R. A., Freeman, G. L. & Li, S., Sep 1 2006, In : Human Gene Therapy. 17, 9, p. 949-959 11 p.

Research output: Contribution to journalArticle

32 Scopus citations
2003

Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor β type II receptor expression in human pancreatic cancer cells

Zhao, S., Venkatasubbarao, K., Li, S. & Freeman, J. W., May 15 2003, In : Cancer Research. 63, 10, p. 2624-2630 7 p.

Research output: Contribution to journalArticle

72 Scopus citations
2002

Gene promoter of apoptosis inhibitory protein IAP2: Identification of enhancer elements and activation by severe hypoxia

Dong, Z., Nishiyama, J., Yi, X., Venkatachalam, M. A., Denton, M., Gu, S., Li, S. & Qiang, M., Jun 1 2002, In : Biochemical Journal. 364, 2, p. 413-421 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Multiple PU.1 sites cooperate in the regulation of p40 phox transcription during granulocytic differentiation of myeloid cells

Li, S. N., Valante, A. J., Qiang, M., Schlegel, W., Gamez, M. & Clark, R. A., Jun 15 2002, In : Blood. 99, 12, p. 4578-4587 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Regulation of calreticulin expression during induction of differentiation in human myeloid cells: Evidence for remodeling of the endoplasmic reticulum

Clark, R. A., Li, S. N., Pearson, D. W., Leidal, K. G., Clark, J. R., Denning, G. M., Reddick, R., Krause, K. H. & Valente, A. J., Aug 30 2002, In : Journal of Biological Chemistry. 277, 35, p. 32369-32378 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
2001

MAP Kinase Phosphatase-1 Gene Transcription in Rat Neuroendocrine Cells Is Modulated by a Calcium-sensitive Block to Elongation in the First Exon

Ryser, S., Tortola, S., Van Haasteren, G., Muda, M., Li, S. & Schlegel, W., Sep 7 2001, In : Journal of Biological Chemistry. 276, 36, p. 33319-33327 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Transcriptional regulation of the p67phox gene: Role of AP-1 in concert with myeloid-specific transcription factors

Li, S. L., Valente, A. J., Wang, L., Gamez, M. J. & Clark, R. A., Oct 19 2001, In : Journal of Biological Chemistry. 276, 42, p. 39368-39378 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Tumour suppressors: Effect of DNA damage on a BRCA1 complex

Li, S., Ting, N. S. Y., Zheng, L., Chen, P. L. & Lee, W. H., Nov 1 2001, In : Nature. 414, 6859, 1 p.

Research output: Contribution to journalArticle

2000

Essential contribution of intron sequences to Ca2+-dependent activation of c-fos transcription in pituitary cells

Van Haasteren, G., Li, S., Ryser, S. & Schlegel, W., Dec 1 2000, In : Neuroendocrinology. 72, 6, p. 368-378 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Essentiality of intron control in the induction of c-fos by glucose and glucoincretin peptides in INS-1 β-cells

Susini, S., Van Haasteren, G., Li, S., Prentki, M. & Schlegel, W., Jan 27 2000, In : FASEB Journal. 14, 1, p. 128-136 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
1999

Calcium signalling and gene expression

Van Haasteren, G., Li, S., Muda, M., Susini, S. & Schlegel, W., Jan 1 1999, In : Journal of Receptor and Signal Transduction Research. 19, 1-4, p. 481-492 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Critical flanking sequences of PU.1 binding sites in myeloid-specific promoters

Li, S. L., Schlegel, W., Valente, A. J. & Clark, R. A., Nov 5 1999, In : Journal of Biological Chemistry. 274, 45, p. 32453-32460 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
1997

Pu.1 Is essential for p47(phox) promoter activity in myeloid cells

Li, S. L., Valente, A. J., Zhao, S. J. & Clark, R. A., Aug 5 1997, In : Journal of Biological Chemistry. 272, 28, p. 17802-17809 8 p.

Research output: Contribution to journalArticle

63 Scopus citations
1996

c-fos mRNA and FOS protein expression is induced by Ca2+ influx in GH3B6 pituitary cells

Li, S. L., Cougnon, N., Bresson-Bépoldin, L., Zhao, S. J. & Schlegel, W., Jun 1996, In : Journal of Molecular Endocrinology. 16, 3, p. 229-238 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
1994

Binding kinetics of the long-acting gonadotropin-releasing hormone (GnRH) antagonist antide to rat pituitary GnRH receptors

Li, S. L., Vuagnat, B., Gruaz, N. M., Eshkol, A., Sizonenko, P. C. & Aubert, M. L., Jul 1994, In : Endocrinology. 135, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Induction of c-fos in pituitary cells by thyrotrophin-releasing hormone and phorbol 12-myristate 13-acetate depends upon Ca2+ influx

Li, S. L., Godson, C., Roche, E., Zhao, S. J., Prentki, M. & Schlegel, W., Jan 1 1994, In : Journal of Molecular Endocrinology. 13, 3, p. 303-312 10 p.

Research output: Contribution to journalArticle

11 Scopus citations