Rita Ghosh

  • 1125 Citations
  • 20 h-Index
19952020

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Article
2020

Attenuation of NAD[P]H:quinone oxidoreductase 1 aggravates prostate cancer and tumor cell plasticity through enhanced TGFβ signaling

Thapa, D., Huang, S. B., Muñoz, A. R., Yang, X., Bedolla, R. G., Hung, C. N., Chen, C. L., Huang, T. H. M., Liss, M. A., Reddick, R. L., Miyamoto, H., Kumar, A. P. & Ghosh, R., Dec 1 2020, In : Communications Biology. 3, 1, 12.

Research output: Contribution to journalArticle

Open Access
2019

Contextual role of E2F1 in suppression of melanoma cell motility and invasiveness

Meng, P., Bedolla, R. G., Yun, H., Fitzpatrick, J. E., Kumar, A. P. & Ghosh, R., Jan 1 2019, In : Molecular Carcinogenesis. 58, 9, p. 1701-1710 10 p.

Research output: Contribution to journalArticle

Receptor tyrosine kinase recepteur d'origine nantais as predictive marker for aggressive prostate cancer in African Americans

Bedolla, R. G., Shah, D. P., Huang, S. B., Reddick, R. L., Ghosh, R. & Kumar, A. P., Jan 1 2019, In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

1 Scopus citations
2018

BRCA1 interacting protein COBRA1 facilitates adaptation to castrate-resistant growth conditions

Yun, H., Bedolla, R., Horning, A., Li, R., Chiang, H. C., Huang, H., Reddick, R., Olumi, A. F., Ghosh, R. & Kumar, A. P., Jul 1 2018, In : International Journal of Molecular Sciences. 19, 7, 2104.

Research output: Contribution to journalArticle

3 Scopus citations

Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1

Chakravarthy, D., Muñoz, A. R., Su, A., Hwang, R. F., Keppler, B. R., Chan, D. E., Halff, G., Ghosh, R. & Kumar, A. P., Apr 10 2018, In : Cancer Letters. 419, p. 103-115 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Suppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation

Hussain, S. S., Huang, S. B., Bedolla, R. G., Rivas, P., Basler, J. W., Swanson, G. P., Hui-Ming Huang, T., Narayanasamy, G., Papanikolaou, N., Miyamoto, H., Yeh, I. T., Reddick, R. L., Pollock, B. H., Ghosh, R. & Kumar, A. P., Oct 1 2018, In : Cancer Letters. 433, p. 232-241 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Combination of Nexrutine and docetaxel suppresses NFκB-mediated activation of c-FLIP

Zhang, Y., Li, L., Wang, J., Cheng, W., Zhang, J., Li, X., Zhang, Z., Gong, J., Ghosh, R., Kumar, A. P. & Xie, J., 2017, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

2 Scopus citations

Downregulation of STAT3/NF-κB potentiates gemcitabine activity in pancreatic cancer cells

Gong, J., Muñoz, A. R., Pingali, S., Payton-Stewart, F., Chan, D. E., Freeman, J. W., Ghosh, R. & Kumar, A. P., Feb 1 2017, In : Molecular Carcinogenesis. 56, 2, p. 402-411 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Pancreatic Cancer: Current Status and Challenges

Muñoz, A. R., Chakravarthy, D., Gong, J., Halff, G. A., Ghosh, R. & Kumar, A. P., Oct 11 2017, (Accepted/In press) In : Current Pharmacology Reports. p. 1-13 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

SETD6 regulates NF-κB signaling in urothelial cell survival: Implications for bladder cancer

Mukherjee, N., Cardenas, E., Bedolla, R. & Ghosh, R., Jan 1 2017, In : Oncotarget. 8, 9, p. 15114-15125 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2016

Autophagy: In the cROSshairs of cancer

Hambright, H. G. & Ghosh, R., Sep 12 2016, (Accepted/In press) In : Biochemical Pharmacology.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity

Yun, H., Xie, J., Olumi, A. F., Ghosh, R. & Kumar, A. P., Jan 1 2015, In : Oncotarget. 6, 13, p. 11600-11613 14 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells

Hambright, H. G., Meng, P., Kumar, A. P. & Ghosh, R., Jan 1 2015, In : Oncotarget. 6, 9, p. 7195-7208 14 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations

Palmatine inhibits growth and invasion in prostate cancer cell: Potential role for rpS6/NFκB/FLIP

Hambright, H. G., Batth, I. S., Xie, J., Ghosh, R. & Kumar, A. P., Oct 1 2015, In : Molecular Carcinogenesis. 54, 10, p. 1227-1234 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

NQO1 suppresses NF-κB-p300 interaction to regulate inflammatory mediators associated with prostate tumorigenesis

Thapa, D., Meng, P., Bedolla, R. G., Reddick, R. L., Kumar, A. P. & Ghosh, R., Oct 1 2014, In : Cancer Research. 74, 19, p. 5644-5655 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth

Gong, J., Muñoz, A. R., Chan, D., Ghosh, R. & Kumar, A. P., 2014, In : Oncotarget. 5, 9, p. 2529-2541 13 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations
2013

Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: Involvement of SIRT1/S6K axis

Li, G., Rivas, P., Bedolla, R., Thapa, D., Reddick, R. L., Ghosh, R. & Kumar, A. P., Jan 1 2013, In : Cancer Prevention Research. 6, 1, p. 27-39 13 p.

Research output: Contribution to journalArticle

43 Scopus citations
2012

Predictive Value of Sp1/Sp3/FLIP Signature for Prostate Cancer Recurrence

Bedolla, R. G., Gong, J., Prihoda, T. J., Yeh, I. T., Thompson, I. M., Ghosh, R. & Kumar, A. P., Sep 13 2012, In : PloS one. 7, 9, e44917.

Research output: Contribution to journalArticle

20 Scopus citations
2011

4-Methylcatechol-induced oxidative stress induces intrinsic apoptotic pathway in metastatic melanoma cells

Payton, F., Bose, R., Alworth, W. L., Kumar, A. P. & Ghosh, R., May 15 2011, In : Biochemical Pharmacology. 81, 10, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2010

Natural products: potential for developing Phellodendron amurense bark extract for prostate cancer management.

Kumar, A. P., Graham, H., Robson, C., Thompson, I. M. & Ghosh, R., May 2010, In : Mini reviews in medicinal chemistry. 10, 5, p. 388-397 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: Potential for prostate cancer management

Ghosh, R., Graham, H., Rivas, P., Tan, X. J., Crosby, K., Bhaskaran, S., Schoolfield, J., Banu, J., Fernandes, G., Yeh, I. T. & Kumar, A. P., Mar 1 2010, In : Anticancer Research. 30, 3, p. 857-866 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2009

2-methoxyestradiol prevents LNCaP tumor development in nude mice: Potential role of G 2/M regulatory proteins

Horny, C., Sri Balasubashini, M., Komanduri, K., Ganapathy, M., Yeh, I. T., Ghosh, R. & Kumar, A. P., Dec 1 2009, In : Journal of Cell Death. 2009, p. 1-8 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Butanol fraction containing berberine or related compound from Nexrutine® inhibits NFκB signaling and induces apoptosis in prostate cancer cells

Muralimanoharan, S. B., Kunnumakkara, A. B., Shylesh, B., Kulkarni, K. H., Haiyan, X., Ming, H., Aggarwal, B. B., Rita, G. & Kumar, A. P., Apr 1 2009, In : Prostate. 69, 5, p. 494-504 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells

Ghosh, R., Ganapathy, M., Alworth, W. L., Chan, D. C. & Kumar, A. P., Jan 1 2009, In : Journal of Steroid Biochemistry and Molecular Biology. 113, 1-2, p. 25-35 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Involvement of FLIP in 2-methoxyestradiol-induced tumor regression in transgenic adenocarcinoma of mouse prostate model

Ganapathy, M., Ghosh, R., Jianping, X., Zhang, X., Bedolla, R., Schoolfield, J., Yeh, I. T., Troyer, D. A., Olumi, A. F. & Kumar, A. P., Mar 1 2009, In : Clinical Cancer Research. 15, 5, p. 1601-1611 11 p.

Research output: Contribution to journalArticle

30 Scopus citations
2 Scopus citations
2007

Akt/cAMP-responsive element binding protein/cyclin D1 network: A novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by nexrutine, a Phellodendron amurense bark extract

Kumar, A. P., Bhaskaran, S., Ganapathy, M., Crosby, K., Davis, M. D., Kochunov, P., Schoolfield, J., Yeh, I. T., Troyer, D. A. & Ghosh, R., May 1 2007, In : Clinical Cancer Research. 13, 9, p. 2784-2794 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: Potential role for nexrutine

Ghosh, R., Garcia, G. E., Crosbyy, K., Inouez, H., Thompson, I. M., Troyer, D. A. & Kumar, A. P., Nov 2007, In : Neoplasia. 9, 11, p. 893-899 7 p.

Research output: Contribution to journalArticle

44 Scopus citations
2005

Eugenol causes melanoma growth suppression through inhibition of E2F1 transcriptional activity

Ghosh, R., Nadiminty, N., Fitzpatrick, J. E., Alworth, W. L., Slaga, T. J. & Kumar, A. P., Feb 18 2005, In : Journal of Biological Chemistry. 280, 7, p. 5812-5819 8 p.

Research output: Contribution to journalArticle

115 Scopus citations
2003

4-Hydroxy-3-methoxybenzoic acid methyl ester: A curcumin derivative targets Akt/NFκB cell survival signaling pathway: Potential for prostate cancer management

Kumar, A. P., Garcia, G. E., Ghosh, R., Rajnarayanan, R. V., Alworth, W. L. & Slaga, T. J., Jan 1 2003, In : Neoplasia. 5, 3, p. 255-266 12 p.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations

Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2-methoxyoestradiol: Therapeutic implications?

Ghosh, R., Ott, A. M., Seetharam, D., Slaga, T. J. & Kumar, A. P., Apr 1 2003, In : Melanoma Research. 13, 2, p. 119-127 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Ultraviolet radiation-induced DNA damage in promoter elements inhibits gene expression

Ghosh, R., Tummala, R. & Mitchell, D. L., Nov 20 2003, In : FEBS Letters. 554, 3, p. 427-432 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2001

Bound transcription factor suppresses photoproduct formation in the NF-κB promoter

Ghosh, R., Paniker, L. & Mitchell, D. L., Jan 1 2001, In : Photochemistry and Photobiology. 73, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
1999

Effect of oxidative DNA damage in promoter elements on transcription factor binding

Ghosh, R. & Mitchell, D. L., Aug 1 1999, In : Nucleic acids research. 27, 15, p. 3213-3218 6 p.

Research output: Contribution to journalArticle

105 Scopus citations
1996

Evidence for a novel DNA damage binding protein in human cells

Ghosh, R., Peng, C. H. & Mitchell, D. L., Jul 9 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 14, p. 6918-6923 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
1995

Generation of oligonucleotides containing site-specific cyclobutane pyrimidine dimers and pyrimidine(6-4)pyrimidinone photoproducts by immunoprecipitation

Ghosh, R., Johnston, D. A. & Mitchell, D. L., Dec 1 1995, In : Nucleic acids research. 23, 23, p. 4934-4937 4 p.

Research output: Contribution to journalArticle

10 Scopus citations