Ralph A Defronzo

  • 90661 Citations
  • 139 h-Index
1967 …2020
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Insulin Medicine & Life Sciences
Glucose Medicine & Life Sciences
Type 2 Diabetes Mellitus Medicine & Life Sciences
Insulin Resistance Medicine & Life Sciences
pioglitazone Medicine & Life Sciences
Glucose Intolerance Medicine & Life Sciences
Fasting Medicine & Life Sciences
Hyperglycemia Medicine & Life Sciences

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Projects 1978 2020

Discovery of Functional Variants in Type 2 Diabetes Genes in Mexican Americans

Abboud, H. E., Duggirala, R., Thameem, F., Blangero, J., Defronzo, R. A. & Lehman, D. M.

National Institutes of Health


Project: Research projectResearch Project--Cooperative Agreements

Type 2 Diabetes Mellitus
Genome-Wide Association Study
Single Nucleotide Polymorphism
Diabetes Complications
Secondary Prevention


Defronzo, R. A. & Kinzell, J.

National Institutes of Health


Project: Research projectSmall Business Innovation Research Grants (SBIR) - Phase II, Small Business Innovation Research Grants (SBIR) - Phase I

Equipment and Supplies

Research Output 1967 2019

Glucose-Mediated Glucose Disposal at Baseline Insulin Is Impaired in IFG

Alatrach, M., Agyin, C., Mehta, R., Adams, J., Defronzo, R. A. & Abdul-ghani, M. A., Jan 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 1, p. 163-171 9 p.

Research output: Contribution to journalArticle

Clamping devices
Glucose Clamp Technique

A novel experimental model for human mixed acinar-ductal pancreatic cancer

Doiron, B. & Defronzo, R. A., Feb 1 2018, In : Carcinogenesis. 39, 2, p. 180-190 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Theoretical Models
Acinar Cell Carcinoma
Ductal Carcinoma

Associations of Hemoglobin A1c With Cardiovascular Disease and Mortality in Chinese Adults With Diabetes

Lu, J., Wang, W., Li, M., Bi, Y., Xu, Y., Chen, L., Zhao, J., Mu, Y., Defronzo, R. A. & Ning, G., Dec 18 2018, In : Journal of the American College of Cardiology. 72, 24, p. 3224-3225 2 p.

Research output: Contribution to journalLetter

Cardiovascular Diseases
77 Citations

Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm - 2018 executive summary

Garber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S., Defronzo, R. A., Einhorn, D., Fonseca, V. A., Garber, J. R., Garvey, W. T., Grunberger, G., Handelsman, Y., Hirsch, I. B., Jellinger, P. S., McGill, J. B., Mechanick, J. I., Rosenblit, P. D. & Umpierrez, G. E., Jan 1 2018, In : Endocrine Practice. 24, 1, p. 91-120 30 p.

Research output: Contribution to journalReview article

Type 2 Diabetes Mellitus
Committee Membership
Randomized Controlled Trials

Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy

Chen, S., Bastarrachea, R. A., Shen, J. S., Laviada-Nagel, A., Rodriguez-Ayala, E., Nava-Gonzalez, E. J., Huang, P., Defronzo, R. A., Kent, J. W. & Grayburn, P. A., Jan 1 2018, (Accepted/In press) In : Gene Therapy.

Research output: Contribution to journalArticle

Brown Adipose Tissue
Genetic Therapy
Skeletal Muscle