Ralph A Defronzo

  • 89457 Citations
  • 137 h-Index
1967 …2020
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Insulin Medicine & Life Sciences
Glucose Medicine & Life Sciences
Type 2 Diabetes Mellitus Medicine & Life Sciences
Insulin Resistance Medicine & Life Sciences
pioglitazone Medicine & Life Sciences
Glucose Intolerance Medicine & Life Sciences
Fasting Medicine & Life Sciences
Hyperglycemia Medicine & Life Sciences

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Projects 1978 2020

Discovery of Functional Variants in Type 2 Diabetes Genes in Mexican Americans

Abboud, H. E., Duggirala, R., Thameem, F., Blangero, J., Defronzo, R. A. & Lehman, D. M.

National Institutes of Health

9/20/094/30/20

Project: Research projectResearch Project--Cooperative Agreements

Type 2 Diabetes Mellitus
Genome-Wide Association Study
Genes
Population
Single Nucleotide Polymorphism
Diabetes Complications
Secondary Prevention
Hyperglycemia
Therapeutics

IMPROVED HYPOGLYCEMIA RESCUE DEVICE

Defronzo, R. A. & Kinzell, J.

National Institutes of Health

9/30/098/31/14

Project: Research projectSmall Business Innovation Research Grants (SBIR) - Phase II, Small Business Innovation Research Grants (SBIR) - Phase I

Glucagon
Hypoglycemia
Equipment and Supplies
Safety
Benchmarking

Research Output 1967 2018

A novel experimental model for human mixed acinar-ductal pancreatic cancer

Doiron, B. & DeFronzo, R. A., Feb 1 2018, In : Carcinogenesis. 39, 2, p. 180-190 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Theoretical Models
Lentivirus
Acinar Cell Carcinoma
Ductal Carcinoma
54 Citations

Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm - 2018 executive summary

Garber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S., DeFronzo, R. A., Einhorn, D., Fonseca, V. A., Garber, J. R., Garvey, W. T., Grunberger, G., Handelsman, Y., Hirsch, I. B., Jellinger, P. S., McGill, J. B., Mechanick, J. I., Rosenblit, P. D. & Umpierrez, G. E., Jan 1 2018, In : Endocrine Practice. 24, 1, p. 91-120 30 p.

Research output: Contribution to journalReview article

Endocrinology
Type 2 Diabetes Mellitus
Consensus
Committee Membership
Randomized Controlled Trials

Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy

Chen, S., Bastarrachea, R. A., Shen, J. S., Laviada-Nagel, A., Rodriguez-Ayala, E., Nava-Gonzalez, E. J., Huang, P., DeFronzo, R. A., Kent, J. W. & Grayburn, P. A., Jan 1 2018, (Accepted/In press) In : Gene Therapy.

Research output: Contribution to journalArticle

Microbubbles
Brown Adipose Tissue
Genetic Therapy
Skeletal Muscle
Genes

Effect of chronic hyperglycemia on glucose metabolism in subjects with normal glucose tolerance

Shannon, C., Merovci, A., Xiong, J., Tripathy, D., Lorenzo, F., McClain, D., Abdul-ghani, M. A., Norton, L. & Defronzo, R. A., Dec 1 2018, In : Diabetes. 67, 12, p. 2507-2517 11 p.

Research output: Contribution to journalArticle

Hyperglycemia
Glucose
Glycogen Synthase
Skeletal Muscle
Insulin
1 Citations

Empagliflozin Treatment Is Associated with Improved β -Cell Function in Type 2 Diabetes Mellitus

Al Jobori, H., Daniele, G., Adams, J., Cersosimo, E., Solis-Herrera, C., Triplitt, C., Defronzo, R. A. & Abdul-Ghani, M., Apr 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 4, p. 1402-1407 6 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Glucose
Therapeutics
Sodium-Glucose Transporter 2
C-Peptide