Peter J Houghton

  • 23641 Citations
  • 81 h-Index
1975 …2019
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Fingerprint Dive into the research topics where Peter J Houghton is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Heterografts Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
irinotecan Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Rhabdomyosarcoma Medicine & Life Sciences
Sirolimus Medicine & Life Sciences
Topotecan Medicine & Life Sciences
Tumors Chemical Compounds

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Research Output 1975 2019

5 Citations (Scopus)

A phase II study of alisertib in children with recurrent/refractory solid tumors or leukemia: Children's Oncology Group Phase I and pilot Consortium (ADVL0921)

Mosse, Y. P., Fox, E., Teachey, D. T., Reid, J. M., Safgren, S. L., Carol, H., Lock, R. B., Houghton, P. J., Smith, M. A., Hall, D., Barkauskas, D. A., Krailo, M., Voss, S. D., Berg, S. L., Blaney, S. M. & Weigel, B. J., Jun 1 2019, In : Clinical Cancer Research. 25, 11, p. 3229-3238 10 p.

Research output: Contribution to journalArticle

Open Access
Leukemia
Aurora Kinase A
Neoplasms
Pharmacokinetics
Pharmacogenetics

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

Khan, S., Zhang, X., Lv, D., Zhang, Q., He, Y., Zhang, P., Liu, X., Thummuri, D., Yuan, Y., Wiegand, J. S., Pei, J., Zhang, W., Sharma, A., McCurdy, C. R., Kuruvilla, V. M., Baran, N., Ferrando, A. A., Kim, Y. M., Rogojina, A., Houghton, P. J. & 5 others, Huang, G., Hromas, R., Konopleva, M., Zheng, G. & Zhou, D., Dec 1 2019, In : Nature Medicine. 25, 12, p. 1938-1947 10 p.

Research output: Contribution to journalArticle

Proteolysis
B-Cell Lymphoma
Platelets
Antineoplastic Agents
Toxicity
6 Citations (Scopus)

Broad spectrum activity of the checkpoint kinase 1 inhibitor prexasertib as a single agent or chemopotentiator across a range of preclinical pediatric tumor models

Lowery, C. D., Dowless, M., Renschler, M., Blosser, W., VanWye, A. B., Stephens, J. R., Iversen, P. W., Lin, A. B., Beckmann, R. P., Krytska, K., Cole, K. A., Maris, J. M., Hawkins, D. S., Rubin, B. P., Kurmasheva, R. T., Houghton, P. J., Gorlick, R., Anders Kolb, E., Kang, M. H., Patrick Reynolds, C. & 4 others, Erickson, S. W., Teicher, B. A., Smith, M. A. & Stancato, L. F., Apr 1 2019, In : Clinical Cancer Research. 25, 7, p. 2278-2289 12 p.

Research output: Contribution to journalArticle

Pediatrics
Neoplasms
Combination Drug Therapy
Heterografts
Sarcoma

Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2

Gardner, H. L., Sivaprakasam, K., Briones, N., Zismann, V., Perdigones, N., Drenner, K., Facista, S., Richholt, R., Liang, W., Aldrich, J., Trent, J. M., Shields, P. G., Robinson, N., Johnson, J., Lana, S., Houghton, P. J., Fenger, J., Lorch, G., Janeway, K. A., London, C. A. & 1 others, Hendricks, W. P. D., Dec 1 2019, In : Communications Biology. 2, 1, 266.

Research output: Contribution to journalArticle

Open Access
osteosarcoma
methyltransferases
Osteosarcoma
histones
Canidae

Challenges and opportunities for childhood cancer drug development

Houghton, P. J. & Kurmasheva, R. T., Oct 1 2019, In : Pharmacological Reviews. 71, 4, p. 671-697 27 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Neoplasms
Therapeutics
Tumor Microenvironment
Cytotoxins

Press/Media

Neuroscientist Susan Amara Named AAAS President-Elect

Peter J Houghton

1/28/20

1 item of Media coverage

Press/Media: Press / Media

UF researchers discover breakthrough anticancer drug

Robert A Hromas & Peter J Houghton

1/2/20

1 item of Media coverage

Press/Media: Press / Media

Leukemia, lymphoma squarely in sights of new class of drugs

Robert A Hromas & Peter J Houghton

12/6/1912/9/19

6 items of Media coverage

Press/Media: Press / Media

Team Develop Drugs To Fight Leukemia and Lymphoma

Robert A Hromas & Peter J Houghton

12/9/19

1 item of Media coverage

Press/Media: Press / Media