Peter J Houghton

  • 22452 Citations
  • 80 h-Index
1975 …2018
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  • 3 Similar Profiles
Heterografts Medicine & Life Sciences
irinotecan Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Rhabdomyosarcoma Medicine & Life Sciences
Sirolimus Medicine & Life Sciences
Topotecan Medicine & Life Sciences
Cell Line Medicine & Life Sciences

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Research Output 1975 2018

Abemaciclib is active in preclinical models of Ewing sarcoma via multipronged regulation of cell cycle, DNA methylation, and interferon pathway signaling

Dowless, M., Lowery, C. D., Shackleford, T., Renschler, M., Stephens, J., Flack, R., Blosser, W., Gupta, S., Stewart, J., Webster, Y., Dempsey, J., VanWye, A. B., Ebert, P., Iversen, P., Olsen, J. B., Gong, X., Buchanan, S., Houghton, P. J. & Stancato, L., Dec 1 2018, In : Clinical Cancer Research. 24, 23, p. 6028-6039 12 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
DNA Methylation
Interferons
Cell Cycle
irinotecan

Classical NF-κB metabolically reprograms sarcoma cells through regulation of hexokinase 2

Londhe, P., Yu, P. Y., Ijiri, Y., Ladner, K. J., Fenger, J. M., London, C., Houghton, P. J. & Guttridge, D. C., Apr 11 2018, In : Frontiers in Oncology. 8, APR, 104.

Research output: Contribution to journalArticle

Hexokinase
Sarcoma
Metabolome
Glycolysis
Osteosarcoma

ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer

Harwood, F. C., Klein Geltink, R. I., O’Hara, B. P., Cardone, M., Janke, L., Finkelstein, D., Entin, I., Paul, L., Houghton, P. J. & Grosveld, G. C., Sep 12 2018, In : Science Advances. 4, 9, eaar3938.

Research output: Contribution to journalArticle

Sirolimus
Neoplasms
Rhabdomyosarcoma
Penetrance
Protein-Serine-Threonine Kinases
3 Citations

Initial testing (stage 1) of M6620 (formerly VX-970), a novel ATR inhibitor, alone and combined with cisplatin and melphalan, by the Pediatric Preclinical Testing Program

Kurmasheva, R. T., Kurmashev, D., Reynolds, C. P., Kang, M., Wu, J., Houghton, P. J. & Smith, M. A., Feb 1 2018, In : Pediatric Blood and Cancer. 65, 2, e26825.

Research output: Contribution to journalArticle

Melphalan
Cisplatin
Pediatrics
Heterografts
Disease-Free Survival

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A. K., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 othersDer, C. J., Nov 12 2018, In : Cancer Cell. 34, 5, p. 807-822.e7

Research output: Contribution to journalArticle

Adenocarcinoma
Ubiquitin-Protein Ligases
Protein Stability
Proteasome Endopeptidase Complex
Growth