Peter J Houghton

Mosse, Y. P., Fox, E., Teachey, D. T., Reid, J. M., Safgren, S. L., Carol, H., Lock, R. B., Houghton, P. J., Smith, M. A., Hall, D., Barkauskas, D. A., Krailo, M., Voss, S. D., Berg, S. L., Blaney, S. M. & Weigel, B. J., Jun 1 2019, In : Clinical Cancer Research. 25, 11, p. 3229-3238 10 p.

Research output: Contribution to journal › Article

Open Access

Leukemia

Aurora Kinase A

Neoplasms

Pharmacokinetics

Pharmacogenetics

A selective BCL-X_L PROTAC degrader achieves safe and potent antitumor activity

Khan, S., Zhang, X., Lv, D., Zhang, Q., He, Y., Zhang, P., Liu, X., Thummuri, D., Yuan, Y., Wiegand, J. S., Pei, J., Zhang, W., Sharma, A., McCurdy, C. R., Kuruvilla, V. M., Baran, N., Ferrando, A. A., Kim, Y. M., Rogojina, A., Houghton, P. J. & 5 others, Huang, G., Hromas, R., Konopleva, M., Zheng, G. & Zhou, D., Dec 1 2019, In : Nature Medicine. 25, 12, p. 1938-1947 10 p.

Research output: Contribution to journal › Article

Proteolysis

B-Cell Lymphoma

Platelets

Antineoplastic Agents

Toxicity

6 Citations (Scopus)

Broad spectrum activity of the checkpoint kinase 1 inhibitor prexasertib as a single agent or chemopotentiator across a range of preclinical pediatric tumor models

Lowery, C. D., Dowless, M., Renschler, M., Blosser, W., VanWye, A. B., Stephens, J. R., Iversen, P. W., Lin, A. B., Beckmann, R. P., Krytska, K., Cole, K. A., Maris, J. M., Hawkins, D. S., Rubin, B. P., Kurmasheva, R. T., Houghton, P. J., Gorlick, R., Anders Kolb, E., Kang, M. H., Patrick Reynolds, C. & 4 others, Erickson, S. W., Teicher, B. A., Smith, M. A. & Stancato, L. F., Apr 1 2019, In : Clinical Cancer Research. 25, 7, p. 2278-2289 12 p.

Research output: Contribution to journal › Article

Pediatrics

Neoplasms

Combination Drug Therapy

Heterografts

Sarcoma

Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2

Gardner, H. L., Sivaprakasam, K., Briones, N., Zismann, V., Perdigones, N., Drenner, K., Facista, S., Richholt, R., Liang, W., Aldrich, J., Trent, J. M., Shields, P. G., Robinson, N., Johnson, J., Lana, S., Houghton, P. J., Fenger, J., Lorch, G., Janeway, K. A., London, C. A. & 1 others, Hendricks, W. P. D., Dec 1 2019, In : Communications Biology. 2, 1, 266.

Research output: Contribution to journal › Article

Open Access

osteosarcoma

methyltransferases

Osteosarcoma

histones

Canidae