Peter J Houghton

  • 22705 Citations
  • 80 h-Index
1975 …2019
If you made any changes in Pure, your changes will be visible here soon.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 1 Similar Profiles
Heterografts Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
irinotecan Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Rhabdomyosarcoma Medicine & Life Sciences
Sirolimus Medicine & Life Sciences
Topotecan Medicine & Life Sciences
Vincristine Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1975 2019

Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma

Sun, W., Chatterjee, B., Shern, J. F., Patidar, R., Song, Y., Wang, Y., Walker, R. L., Pawel, B. R., Linardic, C. M., Houghton, P. J., Hewitt, S. M., Edelman, D. C., Khan, J., Meltzer, P. S. & Barr, F. G., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Rhabdomyosarcoma
DNA Methylation
Neoplasms
Methylation
Heterografts
1 Citations (Scopus)

Abemaciclib is active in preclinical models of Ewing sarcoma via multipronged regulation of cell cycle, DNA methylation, and interferon pathway signaling

Dowless, M., Lowery, C. D., Shackleford, T., Renschler, M., Stephens, J., Flack, R., Blosser, W., Gupta, S., Stewart, J., Webster, Y., Dempsey, J., VanWye, A. B., Ebert, P., Iversen, P., Olsen, J. B., Gong, X., Buchanan, S., Houghton, P. J. & Stancato, L., Dec 1 2018, In : Clinical Cancer Research. 24, 23, p. 6028-6039 12 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
DNA Methylation
Interferons
Cell Cycle
irinotecan

Classical NF-κB metabolically reprograms sarcoma cells through regulation of hexokinase 2

Londhe, P., Yu, P. Y., Ijiri, Y., Ladner, K. J., Fenger, J. M., London, C., Houghton, P. J. & Guttridge, D. C., Apr 11 2018, In : Frontiers in Oncology. 8, APR, 104.

Research output: Contribution to journalArticle

Hexokinase
Sarcoma
Metabolome
Glycolysis
Osteosarcoma

ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer

Harwood, F. C., Klein Geltink, R. I., O’Hara, B. P., Cardone, M., Janke, L., Finkelstein, D., Entin, I., Paul, L., Houghton, P. J. & Grosveld, G. C., Sep 12 2018, In : Science advances. 4, 9, eaar3938.

Research output: Contribution to journalArticle

Sirolimus
Neoplasms
Rhabdomyosarcoma
Penetrance
Protein-Serine-Threonine Kinases
3 Citations (Scopus)

Initial testing (stage 1) of M6620 (formerly VX-970), a novel ATR inhibitor, alone and combined with cisplatin and melphalan, by the Pediatric Preclinical Testing Program

Kurmasheva, R. T., Kurmashev, D., Reynolds, C. P., Kang, M., Wu, J., Houghton, P. J. & Smith, M. A., Feb 1 2018, In : Pediatric Blood and Cancer. 65, 2, e26825.

Research output: Contribution to journalArticle

Melphalan
Cisplatin
Pediatrics
Heterografts
Disease-Free Survival