Paul F Fitzpatrick

  • 5532 Citations
  • 38 h-Index
1978 …2019
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Fingerprint Dive into the research topics where Paul F Fitzpatrick is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Tyrosine 3-Monooxygenase Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Phenylalanine Hydroxylase Medicine & Life Sciences
Flavoproteins Medicine & Life Sciences
Isotopes Medicine & Life Sciences
Catalytic Domain Medicine & Life Sciences
Substrates Chemical Compounds
Hydroxylation Chemical Compounds

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Projects 1992 2018

Phenylalanine
Phenylalanine Hydroxylase
Enzymes
Allosteric Regulation
Phosphorylation
Enzymes and Coenzymes
Metabolic Networks and Pathways
Enzymes
Financial Management
Signal Transduction

AN UNDULATOR RESOURCE FOR STRUCTURAL BIOLOGY

Hart, P. J., Fitzpatrick, P. F., Ealick, S., Quiocho, F., Schlessinger, J., Cerione, R. A., Clardy, J. O. N., Lippard, S., Deacon, A., Capel, M., Xavier, L., Nikolov, D., Yaffe, M., Misono, K., Golden, B. L., Ogata, C., Shapiro, L., Wang, J., Drennan, C., Baker, T., Crane, B., Wimberly, B., Pavletich, N., Eck, M., Steitz, T. A., Verdine, G., Sauer, R., Rapoport, T., Harrison, S. C., Fait, J., Nielsen, C., Mathews, F. S., Rajashankar, K., Breslow, E., Von Dreele, R., Miller, K., Decamilli, P., Phillips, G. N., Stauffacher, C., Keenan, R., Kang, C., Kissinger, C., Cabral, J., Scheraga, H. A., Dealwis, C., Brunzelle, J., Lawrence, C. M., Strobel, S., Tong, H., Petsko, G., Chen, J. U. E., Rongbao, L., Xiaolin, H., Blobel, G., Anderson, W., Furie, B., Malhotra, A., Hong, L., Howard, A. J., Hong, Y., Bartel, D., Sanders, D., Darst, S., Reinisch, K., Tong, L., Patel, D., Sicheri, F., Wu, H. A. O., Hendrickson, W. A., Schwartz, T., Gaudet, R., Ling, H., Lima, C., Mathews, S., Capel, M. S., Kissinger, C. R., Berger, J., Samanta, U., Jianhua, F., Kirchhausen, T. O. M., Morais-Cabral, J., Aaron, J., Taylor, A., Cerione, R. A., Clardy, J. O. N., Abramson, J., Cantley, L. C., Ellenberger, T., Pyle, A. M., Fan, Q., Modis, Y., Lovell, S., D'Aquino Ruiz, J. A., Brunger, A. T., De Camilli, P., Geiger, J., Sakmar, T., Goldberg, J., Caffrey, M. D., Santarsiero, B. D., Hogle, J., Wagner, G., H Eric, X., Fromme, J. C., Lacy, D. B., Anjana, R., Hunt, J., Almo, S., Feigon, J., Sondermann, H., Lippard, S. J., Loll, P., Jardetzky, T., Perozo, E., Dong, Z., Spiller, B., Eisenberg, D., Tahirov, T., Tanner, J., Edward, Y., Stenkamp, R., Schulman, B., Walker, S., Blacklow, S., Zhou, M., Ailong, K., Springer, T., Kent, S., Yeates, T., MacKinnon, R., Song, T., Laronde, N., Xiong, Y., Christianson, D., Keating, A., Cate, J., Gouaux, J. E., Aggarwal, A. K., Jeruzalmi, D., Decamilli, P., Heldwein, E., Bochkarev, A., Garman, S. C., Vivien, Y., van Den Berg, B., Yuxin, M., Murphy, F., Shuman, S., Kamtekar, S., Nimigean, C., Silverstein, R. O. Y., Muesar, T., Yong-Hwan, L., Rajashankar, K., Sukumar, N., Hur, S. U. N., Khan, A., Rongsheng, J., Roux, B., Jogl, G., Nikolov, D., Ha, Y. A., Braddock, D., Aihara, H., Strobel, S., Dunham, C., Herr, A., Hardy, J., Degrado, W., Luecke, H., Fang, L., Sthanam, N., Newcomer, M. E., Feng, G., Hazen, S., Johnson, R., Baxter, J., Dealwis, C., Deivanayagam, C. C. S., Modis, Y., Choe, J., Wucherpfennig, K., Chuan, H., Koide, S., Mancia, F., Lemmon, M. A., Lewis, M., Walter, M., Shapiro, L., Baker, B., Goldberg, J., Santarsiero, B. D., Hogle, J., Chen, B., Asojo, O. A., Joseph, H., Hogbom, M., Konigsberg, W., Bhyravbhatla, B., van Duyne, G., Anjana, R., Ploegh, H., Dauter, Z., Agris, P., Sazinsky, M., Toor, N. S. & Cheng, X.

National Institutes of Health

6/15/013/31/13

Project: Research project

Organized Financing
Podospora
Chlamydia
Plasmids
Enzymes
Flavoproteins
Carbon
Enzymes
D-Amino-Acid Oxidase
Hydrogen bonds

GRADUATE TRAINING IN BIOLOGICAL CHEMISTRY

Fitzpatrick, P. F., Baldwin, T. O., Burgess, K. & Lindahl, P. A.

National Institutes of Health

9/30/948/31/11

Project: Research project

Research Output 1978 2019

  • 5532 Citations
  • 38 h-Index
  • 193 Article
  • 3 Chapter
  • 1 Comment/debate
  • 1 Review article

Mechanism of the Flavoprotein d -6-Hydroxynicotine Oxidase: Substrate Specificity, pH and Solvent Isotope Effects, and Roles of Key Active-Site Residues

Fitzpatrick, P. F., Dougherty, V., Subedi, B., Quilantan, J., Hinck, C. S., Lujan, A. I. & Tormos, J. R., May 28 2019, In : Biochemistry. 58, 21, p. 2534-2541 8 p.

Research output: Contribution to journalArticle

Flavoproteins
4-cresol dehydrogenase (hydroxylating)
Substrate Specificity
Isotopes
Catalytic Domain
1 Citation (Scopus)

The phenylketonuria-associated substitution R68S converts phenylalanine hydroxylase to a constitutively active enzyme but reduces its stability

Khan, C. A., Meisburger, S. P., Ando, N. & Fitzpatrick, P. F., Jan 1 2019, In : Journal of Biological Chemistry. 294, 12, p. 4359-4367 9 p.

Research output: Contribution to journalArticle

Phenylalanine Hydroxylase
Phenylketonurias
Substitution reactions
Enzymes
Phenylalanine

An empirical analysis of enzyme function reporting for experimental reproducibility: Missing/incomplete information in published papers

Halling, P., Fitzpatrick, P. F., Raushel, F. M., Rohwer, J., Schnell, S., Wittig, U., Wohlgemuth, R. & Kettner, C., Nov 1 2018, In : Biophysical Chemistry. 242, p. 22-27 6 p.

Research output: Contribution to journalArticle

Enzymes
Radiation counters
Computer Systems
Metadata
Buffers
1 Citation (Scopus)
Tryptophan Hydroxylase
Mutagenesis
Catalysis
Amino acids
Catalytic Domain
2 Citations (Scopus)

Phosphorylation of Phenylalanine Hydroxylase Increases the Rate Constant for Formation of the Activated Conformation of the Enzyme

Khan, C. A. & Fitzpatrick, P. F., Nov 6 2018, In : Biochemistry. 57, 44, p. 6274-6277 4 p.

Research output: Contribution to journalArticle

Phenylalanine Hydroxylase
Phosphorylation
Phenylalanine
Conformations
Rate constants

Press/Media

U.S. Patents Awarded to Inventors in New York (June 16)

Paul F. Fitzpatrick

6/16/16

1 item of media coverage

Press/Media: Press / Media

Rochester Community Schools board selects finalists for vacancy

Paul F Fitzpatrick

8/19/15

1 item of Media coverage

Press/Media: Press / Media

Smoking cessation important for heart health

Paul F. Fitzpatrick

2/6/15

1 item of media coverage

Press/Media: Press / Media

BUSINESS BRIEFS

Paul F Fitzpatrick

11/5/13

1 item of Media coverage

Press/Media: Press / Media