Mark S Shapiro

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1 Similar Profiles

Neurons Medicine & Life Sciences

Phosphatidylinositols Medicine & Life Sciences

Ion Channels Medicine & Life Sciences

GTP-Binding Proteins Medicine & Life Sciences

Calmodulin Medicine & Life Sciences

Superior Cervical Ganglion Medicine & Life Sciences

Muscarinic Receptors Medicine & Life Sciences

Cholinergic Agents Medicine & Life Sciences

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Projects 2002 2020

1 Active
2 Finished

Clustering of individual and diverse ion channels together into complexes, and their functional coupling, mediated by A-kinase anchoring protein 79/150 in neurons

Shapiro, M. S.

National Institutes of Health

9/30/15 → 7/31/20

Project: Research project

Ion Channels

Protein Kinases

Cluster Analysis

Neurons

Sensory Receptor Cells

Mechanism and functional role of AKAP79/150 in M current control and excitability

Shapiro, M. S.

National Institutes of Health

8/1/09 → 9/29/14

Project: Research project

Neurons

Superior Cervical Ganglion

Protein Kinases

Nodose Ganglion

Calmodulin

Modulation of neuronal ion channels by 2nd messengers

Shapiro, M. S.

National Institutes of Health

6/1/02 → 5/31/16

Project: Research project

Ion Channels

Neurons

Neurotransmitter Agents

Synapses

Nervous System

Research Output 1991 2019

3317 Citations
34 h-Index
68 Article
2 Chapter
1 Comment/debate

A mutually induced conformational fit underlies Ca ² -directed interactions between calmodulin and the proximal C terminus of KCNQ4 K channels

Archer, C. R., Enslow, B. T., Taylor, A. B., De la Rosa, V., Bhattacharya, A. & Shapiro, M. S., Jan 1 2019, In : Journal of Biological Chemistry. 294, 15, p. 6094-6112 19 p.

Research output: Contribution to journal › Article

Calmodulin

Peptides

Thermophoresis

Calorimetry

X ray crystallography

1 Citation (Scopus)

Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 Channels and Activation of TRPC Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Cells

Carver, C. M. & Shapiro, M. S., Feb 27 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 9, p. 1566-1587 22 p.

Research output: Contribution to journal › Article

Transient Receptor Potential Channels

Dentate Gyrus

Muscarinic Receptors

Neurons

Cholinergic Agents

Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, “M-type”) K⁺ currents in neurons

Vigil, F. A., Bozdemir, E., Bugay, V., Chun, S. H., Hobbs, M. A., Sanchez, I., Hastings, S. D., Veraza, R. J., Holstein, D. M., Sprague, S. M., M Carver, C., Cavazos, J. E., Brenner, R., Lechleiter, J. D. & Shapiro, M. S., Jan 1 2019, In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journal › Article

Pharmacology

Neurons

Brain

Physiological Stress

Seizures

1 Citation (Scopus)

Phosphatidylinositol 4,5-bisphosphate (PIP₂) regulates KCNQ3 K channels by interacting with four cytoplasmic channel domains

Choveau, F. S., De la Rosa, V., Bierbower, S. M., Hernandez, C. C. & Shapiro, M. S., Jan 1 2018, In : Journal of Biological Chemistry. 293, 50, p. 19411-19428 18 p.

Research output: Contribution to journal › Article

Zebrafish

Phosphatidylinositols

Voltage-Gated Potassium Channels

S 6

Tissue culture

5 Citations (Scopus)

Downregulation of KCNMB4 expression and changes in BK channel subtype in hippocampal granule neurons following seizure activity

Whitmire, L. E., Ling, L., Bugay, V., Carver, C. M., Timilsina, S., Chuang, H. H., Jaffe, D. B., Shapiro, M. S., Cavazos, J. E. & Brenner, R., Nov 1 2017, In : PLoS One. 12, 11, e0188064.

Research output: Contribution to journal › Article

Large-Conductance Calcium-Activated Potassium Channels

seizures

Neurons

granules

Seizures