Mark S Shapiro

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2 Similar Profiles

Neurons Medicine & Life Sciences

Phosphatidylinositols Medicine & Life Sciences

Ion Channels Medicine & Life Sciences

GTP-Binding Proteins Medicine & Life Sciences

Calmodulin Medicine & Life Sciences

Superior Cervical Ganglion Medicine & Life Sciences

Muscarinic Receptors Medicine & Life Sciences

Cholinergic Agents Medicine & Life Sciences

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Projects 2002 2020

1 Active
2 Finished

Clustering of individual and diverse ion channels together into complexes, and their functional coupling, mediated by A-kinase anchoring protein 79/150 in neurons

Shapiro, M. S.

National Institutes of Health

9/30/15 → 7/31/20

Project: Research project

Ion Channels

Protein Kinases

Cluster Analysis

Neurons

Sensory Receptor Cells

Mechanism and functional role of AKAP79/150 in M current control and excitability

Shapiro, M. S.

National Institutes of Health

8/1/09 → 9/29/14

Project: Research project

Neurons

Superior Cervical Ganglion

Protein Kinases

Nodose Ganglion

Calmodulin

Modulation of neuronal ion channels by 2nd messengers

Shapiro, M. S.

National Institutes of Health

6/1/02 → 5/31/16

Project: Research project

Ion Channels

Neurons

Neurotransmitter Agents

Synapses

Nervous System

Research Output 1991 2019

3341 Citations
35 h-Index
69 Article
2 Chapter
1 Comment/debate

A mutually induced conformational fit underlies Ca ² -directed interactions between calmodulin and the proximal C terminus of KCNQ4 K channels

Archer, C. R., Enslow, B. T., Taylor, A. B., De la Rosa, V., Bhattacharya, A. & Shapiro, M. S., Jan 1 2019, In : Journal of Biological Chemistry. 294, 15, p. 6094-6112 19 p.

Research output: Contribution to journal › Article

Calmodulin

Peptides

Thermophoresis

Calorimetry

X ray crystallography

Functional responses of the hippocampus to hyperexcitability depend on directed, neuron-specific KCNQ2 K⁺ channel plasticity

Carver, C. M., Hastings, S. D., Cook, M. E. & Shapiro, M. S., Jan 1 2019, (Accepted/In press) In : Hippocampus.

Research output: Contribution to journal › Article

Hippocampus

Neurons

Seizures

Messenger RNA

Pentylenetetrazole

2 Citations (Scopus)

Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 Channels and Activation of TRPC Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Cells

Carver, C. M. & Shapiro, M. S., Feb 27 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 9, p. 1566-1587 22 p.

Research output: Contribution to journal › Article

Transient Receptor Potential Channels

Dentate Gyrus

Muscarinic Receptors

Neurons

Cholinergic Agents

1 Citation (Scopus)

Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, “M-type”) K⁺ currents in neurons

Vigil, F. A., Bozdemir, E., Bugay, V., Chun, S. H., Hobbs, M. A., Sanchez, I., Hastings, S. D., Veraza, R. J., Holstein, D. M., Sprague, S. M., M Carver, C., Cavazos, J. E., Brenner, R., Lechleiter, J. D. & Shapiro, M. S., Jan 1 2019, In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journal › Article

Pharmacology

Neurons

Brain

Physiological Stress

Seizures

2 Citations (Scopus)

Phosphatidylinositol 4,5-bisphosphate (PIP₂) regulates KCNQ3 K channels by interacting with four cytoplasmic channel domains

Choveau, F. S., De la Rosa, V., Bierbower, S. M., Hernandez, C. C. & Shapiro, M. S., Jan 1 2018, In : Journal of Biological Chemistry. 293, 50, p. 19411-19428 18 p.

Research output: Contribution to journal › Article

Zebrafish

Phosphatidylinositols

Mark S Shapiro & Robert Brenner

7/20/19

2 items of Media coverage

Press/Media: Press / Media