Madesh Muniswamy

  • 10131 Citations
  • 51 h-Index
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  • 2 Similar Profiles
Mitochondria Chemical Compounds
Calcium Medicine & Life Sciences
Reactive Oxygen Species Medicine & Life Sciences
Superoxides Medicine & Life Sciences
Energy Metabolism Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Cardiac Myocytes Medicine & Life Sciences
Cell Death Medicine & Life Sciences

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Research Output 1997 2019

  • 10131 Citations
  • 51 h-Index
  • 133 Article
  • 8 Review article
  • 7 Comment/debate
  • 1 Editorial
8 Citations (Scopus)

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

Woods, J. J., Nemani, N., Shanmughapriya, S., Kumar, A., Zhang, M., Nathan, S. R., Thomas, M., Carvalho, E., Ramachandran, K., Srikantan, S., Stathopulos, P. B., Wilson, J. J. & Muniswamy, M., Jan 1 2019, (Accepted/In press) In : ACS Central Science.

Research output: Contribution to journalArticle

Signal transduction

Blockade of MCU-Mediated Ca 2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

Tomar, D., Jaña, F., Dong, Z., Quinn, W. J., Jadiya, P., Breves, S. L., Daw, C. C., Srikantan, S., Shanmughapriya, S., Nemani, N., Carvalho, E., Tripathi, A., Worth, A. M., Zhang, X., Razmpour, R., Seelam, A., Rhode, S., Mehta, A. V., Murray, M., Slade, D. & 12 others, Ramirez, S. H., Mishra, P., Gerhard, G. S., Caplan, J., Norton, L., Sharma, K., Rajan, S., Balciunas, D., Wijesinghe, D. S., Ahima, R. S., Baur, J. A. & Muniswamy, M., Mar 26 2019, In : Cell Reports. 26, 13, p. 3709-3725.e7

Research output: Contribution to journalArticle

Open Access
AMP-Activated Protein Kinases
Lipid Metabolism
4 Citations (Scopus)

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

Kokkinaki, D., Hoffman, M., Kalliora, C., Kyriazis, I. D., Maning, J., Lucchese, A. M., Shanmughapriya, S., Tomar, D., Park, J. Y., Wang, H., Yang, X. F., Muniswamy, M., Lymperopoulos, A., Koch, W. J., Christofidou-Solomidou, M. & Drosatos, K., Feb 1 2019, In : Journal of Molecular and Cellular Cardiology. 127, p. 232-245 14 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Reactive Oxygen Species
1 Citation (Scopus)

Complex I and II are required for normal mitochondrial Ca2+ homeostasis

Jaña, F., Bustos, G., Rivas, J., Cruz, P., Urra, F., Basualto-Alarcón, C., Sagredo, E., Ríos, M., Lovy, A., Dong, Z., Cerda, O., Madesh, M. & Cárdenas, C., Nov 1 2019, In : Mitochondrion. 49, p. 73-82 10 p.

Research output: Contribution to journalArticle

Electron Transport
Mitochondrial Membrane Potential
2 Citations (Scopus)

Dual PPARα/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction

Kalliora, C., Kyriazis, I. D., Oka, S. I., Lieu, M. J., Yue, Y., Area-Gomez, E., Pol, C. J., Tian, Y., Mizushima, W., Chin, A., Scerbo, D., Schulze, P. C., Civelek, M., Sadoshima, J., Madesh, M., Goldberg, I. J. & Drosatos, K., Sep 5 2019, In : JCI Insight. 4, 17, e129556.

Research output: Contribution to journalArticle

Open Access
Sirtuin 1
Peroxisome Proliferator-Activated Receptors
Leptin Receptors
High Fat Diet
Organelle Biogenesis