Madesh Muniswamy

Woods, J. J., Nemani, N., Shanmughapriya, S., Kumar, A., Zhang, M., Nathan, S. R., Thomas, M., Carvalho, E., Ramachandran, K., Srikantan, S., Stathopulos, P. B., Wilson, J. J. & Muniswamy, M., Jan 1 2019, (Accepted/In press) In : ACS Central Science.

Research output: Contribution to journal › Article

Calcium

Signal transduction

Mutagenesis

Ruthenium

Poisons

Blockade of MCU-Mediated Ca ²⁺ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

Tomar, D., Jaña, F., Dong, Z., Quinn, W. J., Jadiya, P., Breves, S. L., Daw, C. C., Srikantan, S., Shanmughapriya, S., Nemani, N., Carvalho, E., Tripathi, A., Worth, A. M., Zhang, X., Razmpour, R., Seelam, A., Rhode, S., Mehta, A. V., Murray, M., Slade, D. & 12 others, Ramirez, S. H., Mishra, P., Gerhard, G. S., Caplan, J., Norton, L., Sharma, K., Rajan, S., Balciunas, D., Wijesinghe, D. S., Ahima, R. S., Baur, J. A. & Muniswamy, M., Mar 26 2019, In : Cell Reports. 26, 13, p. 3709-3725.e7

Research output: Contribution to journal › Article

Open Access

AMP-Activated Protein Kinases

Lipid Metabolism

Lipids

Liver

Homeostasis

4 Citations (Scopus)

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

Kokkinaki, D., Hoffman, M., Kalliora, C., Kyriazis, I. D., Maning, J., Lucchese, A. M., Shanmughapriya, S., Tomar, D., Park, J. Y., Wang, H., Yang, X. F., Muniswamy, M., Lymperopoulos, A., Koch, W. J., Christofidou-Solomidou, M. & Drosatos, K., Feb 1 2019, In : Journal of Molecular and Cellular Cardiology. 127, p. 232-245 14 p.

Research output: Contribution to journal › Article

Cardiomyopathies

Punctures

Cardiac Myocytes

Ligation

Reactive Oxygen Species

1 Citation (Scopus)

Complex I and II are required for normal mitochondrial Ca²⁺ homeostasis

Jaña, F., Bustos, G., Rivas, J., Cruz, P., Urra, F., Basualto-Alarcón, C., Sagredo, E., Ríos, M., Lovy, A., Dong, Z., Cerda, O., Madesh, M. & Cárdenas, C., Nov 1 2019, In : Mitochondrion. 49, p. 73-82 10 p.

Research output: Contribution to journal › Article

Electron Transport

Homeostasis

Mitochondrial Membrane Potential

Mitochondria

Calcium

2 Citations (Scopus)

Dual PPARα/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction

Kalliora, C., Kyriazis, I. D., Oka, S. I., Lieu, M. J., Yue, Y., Area-Gomez, E., Pol, C. J., Tian, Y., Mizushima, W., Chin, A., Scerbo, D., Schulze, P. C., Civelek, M., Sadoshima, J., Madesh, M., Goldberg, I. J. & Drosatos, K., Sep 5 2019, In : JCI Insight. 4, 17, e129556.

Research output: Contribution to journal › Article

Open Access

Sirtuin 1

Peroxisome Proliferator-Activated Receptors

Leptin Receptors

High Fat Diet

Organelle Biogenesis