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Collaborations and top research areas from the last five years
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Cryo-EM structures of UBA6 reveal mechanisms of E1–E2 specificity and dual FAT10/ubiquitin thioester transfer
Nayak, D., Jia, L., dos Santos Bury, P., Ruben, E. A., Shukla, A., Nayak, A., Stratton, C. M., Ebadi, P., Cho, H., Tumanova, A. A., Varughese, J. T., Yuan, L., Gao, F., Cano, K. E., Davies, C., Sung, P., Gack, M. U., Wasmuth, E. V. & Olsen, S. K., Dec 2026, In: Nature communications. 17, 1, 3302.Research output: Contribution to journal › Article › peer-review
Open Access -
Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain
Clark, N. E., Katolik, A., Gallant, P., Welch, A., Murphy, E., Buerer, L., Schorl, C., Naik, N., Naik, M. T., Holloway, S. P., Cano, K., Weintraub, S. T., Howard, K. M., Hart, P. J., Jogl, G., Damha, M. J. & Fairbrother, W. G., Sep 2023, In: Journal of Biological Chemistry. 299, 9, 105100.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer
Afsar, M., Liu, G. Q., Jia, L., Ruben, E. A., Nayak, D., Sayyad, Z., Bury, P. D. S., Cano, K. E., Nayak, A., Zhao, X. R., Shukla, A., Sung, P., Wasmuth, E. V., Gack, M. U. & Olsen, S. K., Dec 2023, In: Nature communications. 14, 1, 4786.Research output: Contribution to journal › Article › peer-review
Open Access19 Link opens in a new tab Scopus citations -
Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6
Yuan, L., Gao, F., Lv, Z., Nayak, D., Nayak, A., Santos Bury, P. D., Cano, K. E., Jia, L., Oleinik, N., Atilgan, F. C., Ogretmen, B., Williams, K. M., Davies, C., El Oualid, F., Wasmuth, E. V. & Olsen, S. K., Dec 2022, In: Nature communications. 13, 1, 4880.Research output: Contribution to journal › Article › peer-review
Open Access12 Link opens in a new tab Scopus citations -
Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development
Lv, Z., Cano, K. E., Jia, L., Drag, M., Huang, T. T. & Olsen, S. K., Feb 3 2022, In: Frontiers in Chemistry. 9, 819165.Research output: Contribution to journal › Review article › peer-review
Open Access82 Link opens in a new tab Scopus citations
Datasets
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Crystal structure of the DNA binding domain of transcription factor FLI1 in complex with an 11-mer DNA GACCGGAAGTG
Hou, C. (Contributor), Weidenbach, S. (Contributor), Cano, K. E. (Contributor), Wang, Z. (Contributor), Mitra, P. (Contributor), Ivanov, D. N. (Contributor), Rohr, J. (Contributor) & Tsodikov, O. V. (Contributor), Protein Data Bank (PDB), Sep 14 2016
DOI: 10.2210/pdb5JVT/pdb, https://www.wwpdb.org/pdb?id=pdb_00005jvt
Dataset
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Crystal structure of mithramycin analogue MTM SA-Trp in complex with a 10-mer DNA AGAGGCCTCT.
Hou, C. (Contributor), Weidenbach, S. (Contributor), Cano, K. E. (Contributor), Wang, Z. (Contributor), Mitra, P. (Contributor), Ivanov, D. N. (Contributor), Rohr, J. (Contributor) & Tsodikov, O. V. (Contributor), Protein Data Bank (PDB), Sep 14 2016
DOI: 10.2210/pdb5JVW/pdb, https://www.wwpdb.org/pdb?id=pdb_00005jvw
Dataset
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Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGTACCCT
Hou, C. (Contributor), Weidenbach, S. (Contributor), Cano, K. E. (Contributor), Wang, Z. (Contributor), Mitra, P. (Contributor), Ivanov, D. N. (Contributor), Rohr, J. (Contributor) & Tsodikov, O. V. (Contributor), Protein Data Bank (PDB), Sep 14 2016
DOI: 10.2210/pdb5JW0/pdb, https://www.wwpdb.org/pdb?id=pdb_00005jw0
Dataset
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Crystal Structures of the bispecific ubiquitin/FAT10 activating enzyme, Uba6
Yuan, L. (Contributor), Gao, F. (Contributor), Lv, Z. (Contributor), Nayak, D. (Contributor), Nayak, A. (Contributor), Santos Bury, P. D. (Contributor), Cano, K. E. (Contributor), Jia, L. (Contributor), Oleinik, N. (Contributor), Atilgan, F. C. (Contributor), Ogretmen, B. (Contributor), Williams, K. M. (Contributor), Davies, C. (Contributor), El Oualid, F. (Contributor), Wasmuth, E. V. (Contributor) & Olsen, S. K. (Contributor), Protein Data Bank (PDB), Nov 2 2022
DOI: 10.2210/pdb7SOL/pdb, https://www.wwpdb.org/pdb?id=pdb_00007sol
Dataset
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Miniature TGF-beta2 3-mutant monomer
Kim, S. K. (Contributor), Barron, L. (Contributor), Hinck, C. S. (Contributor), Petrunak, E. M. (Contributor), Cano, K. E. (Contributor), Thangirala, A. (Contributor), Iskra, B. (Contributor), Brothers, M. (Contributor), Vonberg, M. (Contributor), Leal, B. (Contributor), Richter, B. (Contributor), Kodali, R. (Contributor), Taylor, A. B. (Contributor), Du, S. (Contributor), Barnes, C. O. (Contributor), Sulea, T. (Contributor), Calero, G. (Contributor), Hart, P. J. (Contributor), Hart, M. J. (Contributor), Demeler, B. (Contributor) & Hinck, A. P. (Contributor), Protein Data Bank (PDB), Mar 1 2017
DOI: 10.2210/pdb5TX2/pdb, https://www.wwpdb.org/pdb?id=pdb_00005tx2
Dataset