James F Nelson

  • 10387 Citations
  • 43 h-Index
1975 …2020

Research output per year

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Research Output

  • 10387 Citations
  • 43 h-Index
  • 94 Article
  • 4 Review article
  • 1 Comment/debate
  • 1 Letter
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Article
2020

Mobilization-based transplantation of young-donor hematopoietic stem cells extends lifespan in mice

Guderyon, M. J., Chen, C., Bhattacharjee, A., Ge, G., Fernandez, R. A., Gelfond, J. A. L., Gorena, K. M., Cheng, C. J., Li, Y., Nelson, J. F., Strong, R. J., Hornsby, P. J., Clark, R. A. & Li, S., Mar 1 2020, In : Aging cell. 19, 3, e13110.

Research output: Contribution to journalArticle

Open Access
2019

Acarbose improves health and lifespan in aging HET3 mice

Harrison, D. E., Strong, R., Alavez, S., Astle, C. M., DiGiovanni, J., Fernandez, E., Flurkey, K., Garratt, M., Gelfond, J. A. L., Javors, M. A., Levi, M., Lithgow, G. J., Macchiarini, F., Nelson, J. F., Sukoff Rizzo, S. J., Slaga, T. J., Stearns, T., Wilkinson, J. E. & Miller, R. A., Apr 2019, In : Aging cell. 18, 2, e12898.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
Open Access
3 Scopus citations

Glycine supplementation extends lifespan of male and female mice

Miller, R. A., Harrison, D. E., Astle, C. M., Bogue, M. A., Brind, J., Fernandez, E., Flurkey, K., Javors, M., Ladiges, W., Leeuwenburgh, C., Macchiarini, F., Nelson, J., Ryazanov, A. G., Snyder, J., Stearns, T. M., Vaughan, D. E. & Strong, R., Jun 2019, In : Aging cell. 18, 3, e12953.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Hyperadrenocorticism of calorie restriction contributes to its anti-inflammatory action in mice

Allen, B. D., Liao, C. Y., Shu, J., Muglia, L. J., Majzoub, J. A., Diaz, V. & Nelson, J. F., Jun 2019, In : Aging cell. 18, 3, e12944.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Hydrogen sulfide ameliorates aging-associated changes in the kidney

Lee, H. J., Feliers, D., Barnes, J. L., Oh, S., Choudhury, G. G., Diaz, V., Galvan, V., Strong, R., Nelson, J., Salmon, A., Kevil, C. G. & Kasinath, B. S., Apr 1 2018, In : GeroScience. 40, 2, p. 163-176 14 p.

Research output: Contribution to journalArticle

17 Scopus citations
2016

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., Fernandez, E., Flurkey, K., Hamilton, K. L., Lamming, D. W., Javors, M. A., de Magalhães, J. P., Martinez, P. A., McCord, J. M., Miller, B. F., Müller, M., Nelson, J. F., Ndukum, J., Rainger, G. E., Richardson, A. & 6 others, Sabatini, D. M., Salmon, A. B., Simpkins, J. W., Steegenga, W. T., Nadon, N. L. & Harrison, D. E., Oct 1 2016, In : Aging cell. 15, 5, p. 872-884 13 p.

Research output: Contribution to journalArticle

96 Scopus citations
2014

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Harrison, D. E., Strong, R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., Nelson, J. F., Pletcher, S., Simpkins, J. W., Smith, D., Wilkinson, J. E. & Miller, R. A., Apr 2014, In : Aging cell. 13, 2, p. 273-282 10 p.

Research output: Contribution to journalArticle

147 Scopus citations

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Miller, R. A., Harrison, D. E., Astle, C. M., Fernandez, E., Flurkey, K., Han, M., Javors, M. A., Li, X., Nadon, N. L., Nelson, J. F., Pletcher, S., Salmon, A. B., Sharp, Z. D., Van Roekel, S., Winkleman, L. & Strong, R., Jun 2014, In : Aging cell. 13, 3, p. 468-477 10 p.

Research output: Contribution to journalArticle

260 Scopus citations
2013

Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice

Strong, R., Miller, R. A., Astle, C. M., Baur, J. A., De Cabo, R., Fernandez, E., Guo, W., Javors, M., Kirkland, J. L., Nelson, J. F., Sinclair, D. A., Teter, B., Williams, D., Zaveri, N., Nadon, N. L. & Harrison, D. E., Jan 2013, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 68, 1, p. 6-16 11 p.

Research output: Contribution to journalArticle

121 Scopus citations

Genetic variation in responses to dietary restriction - An unbiased tool for hypothesis testing

Liao, C. Y., Johnson, T. E. & Nelson, J. F., Oct 1 2013, In : Experimental Gerontology. 48, 10, p. 1025-1029 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
2012
17 Scopus citations
2011

Fat maintenance is a predictor of the murine lifespan response to dietary restriction

Liao, C. Y., Rikke, B. A., Johnson, T. E., Gelfond, J. A. L., Diaz, V. & Nelson, J. F., Aug 1 2011, In : Aging Cell. 10, 4, p. 629-639 11 p.

Research output: Contribution to journalArticle

75 Scopus citations

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., De Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., Orihuela, C. J., Pletcher, S., Sharp, Z. D., Sinclair, D., Starnes, J. W., Wilkinson, J. E., Nadon, N. L. & Strong, R., Feb 1 2011, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 66 A, 2, p. 191-201 11 p.

Research output: Contribution to journalArticle

558 Scopus citations
2010

Genetic dissection of dietary restriction in mice supports the metabolic efficiency model of life extension

Rikke, B. A., Liao, C. Y., McQueen, M. B., Nelson, J. F. & Johnson, T. E., Sep 1 2010, In : Experimental Gerontology. 45, 9, p. 691-701 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Genetic variation in the murine lifespan response to dietary restriction: From life extension to life shortening

Liao, C. Y., Rikke, B. A., Johnson, T. E., Diaz, V. & Nelson, J. F., Feb 1 2010, In : Aging cell. 9, 1, p. 92-95 4 p.

Research output: Contribution to journalArticle

288 Scopus citations
2009

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., Pahor, M., Javors, M. A., Fernandez, E. & Miller, R. A., Jul 16 2009, In : Nature. 460, 7253, p. 392-395 4 p.

Research output: Contribution to journalArticle

2206 Scopus citations
2008

Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues

Garcia, A. M., Busuttil, R. A., Calder, R. B., Dollé, M. E. T., Diaz, V., McMahan, C. A., Bartke, A., Nelson, J., Reddick, R. & Vijg, J., Sep 2008, In : Mechanisms of Ageing and Development. 129, 9, p. 528-533 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

Strong, R., Miller, R. A., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., Nadon, N. L., Warner, H. R. & Harrison, D. E., Sep 30 2008, In : Aging cell. 7, 5, p. 641-650 10 p.

Research output: Contribution to journalArticle

178 Scopus citations
2007

An aging Interventions Testing Program: Study design and interim report

Miller, R. A., Harrison, D. E., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., Nadon, N. L., Warner, H. R. & Strong, R., Aug 1 2007, In : Aging Cell. 6, 4, p. 565-575 11 p.

Research output: Contribution to journalArticle

109 Scopus citations

Intra-organ variation in age-related mutation accumulation in the mouse

Busuttil, R. A., Garcia, A. M., Reddick, R. L., Dollé, M. E. T., Calder, R. B., Nelson, J. E. & Vijg, J., Sep 12 2007, In : PloS one. 2, 9, e876.

Research output: Contribution to journalArticle

45 Scopus citations
2005

Housing density does not influence the longevity effect of calorie restriction

Ikeno, Y., Hubbard, G. B., Lee, S., Richardson, A., Strong, R., Diaz, V. & Nelson, J. F., Dec 2005, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 60, 12, p. 1510-1517 8 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations
2004

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T. T., Nelson, J., Strong, R. & Richardson, A., Apr 1 2004, In : Physiological Genomics. 16, p. 29-37 9 p.

Research output: Contribution to journalArticle

535 Scopus citations
Open Access
58 Scopus citations

The role of insulin and insulin-like growth factor-I in mammalian ageing

Richardson, A., Liu, F., Adamo, M. L., Van Remmen, H. & Nelson, J. F., Sep 2004, In : Best Practice and Research: Clinical Endocrinology and Metabolism. 18, 3, p. 393-406 14 p.

Research output: Contribution to journalArticle

54 Scopus citations
2003
7 Scopus citations

Genetic mouse models of extended lifespan

Liang, H., Masoro, E. J., Nelson, J. F., Strong, R., McMahan, C. A. & Richardson, A., Jan 1 2003, In : Experimental Gerontology. 38, 11-12, p. 1353-1364 12 p.

Research output: Contribution to journalArticle

177 Scopus citations

Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice

Sharp, Z. D., Lee, W. H., Nikitin, A. Y., Flesken-Nikitin, A., Ikeno, Y., Reddick, R., Richardson, A. G. & Nelson, J. F., Feb 1 2003, In : Carcinogenesis. 24, 2, p. 179-183 5 p.

Research output: Contribution to journalArticle

11 Scopus citations
2002

Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice

Guo, Z. M., Mitchell-Raymundo, F., Yang, H., Ikeno, Y., Nelson, J., Diaz, V., Richardson, A. & Reddick, R., Apr 30 2002, In : Mechanisms of Ageing and Development. 123, 8, p. 1121-1131 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Melatonin fails to modulate immune parameters influenced by calorie restriction in aging Fischer 344 rats

Pahlavani, M. A., Vargas, D. A., Evans, T. R., Shu, J. H. & Nelson, J. F., Mar 2002, In : Experimental Biology and Medicine. 227, 3, p. 201-207 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
2001

Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury

Chandrasekar, B., Nelson, J. F., Colston, J. T. & Freeman, G. L., May 1 2001, In : American Journal of Physiology - Heart and Circulatory Physiology. 280, 5 49-5, p. H2094-H2102

Research output: Contribution to journalArticle

75 Scopus citations

Chronic administration of pharmacological levels of melatonin does not ameliorate the MPTP-induced degeneration of the nigrostriatal pathway

Morgan, W. W. & Nelson, J. F., Dec 7 2001, In : Brain Research. 921, 1-2, p. 115-121 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
Open Access
43 Scopus citations

Food restriction differentially affects pituitary hormone mRNAs throughout the adult life span of male F344 rats

Han, E. S., Evans, T. R., Lee, S. & Nelson, J. F., Jan 1 2001, In : Journal of Nutrition. 131, 6, p. 1687-1693 7 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
Open Access
36 Scopus citations

Health span and life span in transgenic mice with modulated DNA repair

Walter, C. A., Zhou, Z. Q., Manguino, D., Ikeno, Y., Reddick, R., Nelson, J., Intano, G., Herbert, D. C., Alex McMahan, C. & Hanes, M., Jan 1 2001, In : Annals of the New York Academy of Sciences. 928, p. 132-140 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2000

cDNA expression arrays reveal incomplete reversal of age-related changes in gene expression by calorie restriction

Han, E. S., Hilsenbeck, S. G., Richardson, A. & Nelson, J. F., Jun 20 2000, In : Mechanisms of Ageing and Development. 115, 3, p. 157-174 18 p.

Research output: Contribution to journalArticle

42 Scopus citations
1998

Adrenocortical responsiveness to adrenocorticotropic hormone is enhanced in chronically food-restricted rats

Han, E. S., Evans, T. R. & Nelson, J. F., Sep 1 1998, In : Journal of Nutrition. 128, 9, p. 1415-1420 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Effects of Aloe vera ingestion in the rat. II. Hormonal and metabolic characteristics

Herlihy, J. T., Kim, J. D., Kalu, D. N., Nelson, J. F., Ward, W. F., Ikeno, Y. & Yu, B. P., Aug 1 1998, In : Phytotherapy Research. 12, 5, p. 355-360 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
Open Access
11 Scopus citations
1997

Use of transgenic mice in aging research

Richardson, A., Heydari, A. R., Morgan, W. W., Nelson, J. F., Sharp, Z. D. & Walter, C. A., Jan 1 1997, In : ILAR Journal. 38, 3, p. 124-136 13 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
1996
4 Scopus citations

Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer

Rothenberg, M. L., Eckardt, J. R., Kuhn, J. G., Burris, H. A., Nelson, J., Hilsenbeck, S. G., Rodriguez, G. I., Thurman, A. M., Smith, L. S., Eckhardt, S. G., Weiss, G. R., Elfring, G. L., Rinaldi, D. A., Schaaf, L. J. & Von Hoff, D. D., Apr 1996, In : Journal of Clinical Oncology. 14, 4, p. 1128-1135 8 p.

Research output: Contribution to journalArticle

333 Scopus citations
1995

Author's response to commentaries

Nelson, J. F., Jan 1 1995, In : Neurobiology of Aging. 16, 5, p. 855-856 2 p.

Research output: Contribution to journalArticle

Food restriction delays the age-related increase in GFAP mRNA in rat hypothalamus

Nichols, N. R., Finch, C. E. & Nelson, J. F., Jan 1 1995, In : Neurobiology of Aging. 16, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Hyperadrenocorticism, attenuated inflammation, and the life-prolonging action of food restriction in mice

Klebanov, S., Diais, S., Stavinoha, W. B., Suh, Y. & Nelson, J. F., Jan 1 1995, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 50, 2, p. B78-B82

Research output: Contribution to journalArticle

86 Scopus citations
36 Scopus citations

Neuroendocrine involvement in aging: Evidence from studies of reproductive aging and caloric restriction

Nelson, J. F., Karelus, K., Bergman, M. D. & Felicio, L. S., Jan 1 1995, In : Neurobiology of Aging. 16, 5, p. 837-843 7 p.

Research output: Contribution to journalArticle

112 Scopus citations

Proliferating cell nuclear antigen marks the initiation of follicular growth in the rat

Oktay, K., Schenken, R. S. & Nelson, J. F., Aug 30 1995, In : Biology of reproduction. 53, 2, p. 295-301 7 p.

Research output: Contribution to journalArticle

178 Scopus citations
1994

Calorie Restriction as a Probe for Understanding Neuroendocrine Involvement in the Aging Processes

Nelson, J. F., Jun 1 1994, In : Neuroprotocols. 4, 3, p. 204-209 6 p.

Research output: Contribution to journalArticle

7 Scopus citations