James D Lechleiter

  • 5133 Citations
  • 33 h-Index
1984 …2020
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Oocytes Medicine & Life Sciences
Xenopus Medicine & Life Sciences
Astrocytes Medicine & Life Sciences
Calcium Signaling Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
Xenopus laevis Medicine & Life Sciences
Confocal Microscopy Medicine & Life Sciences
Calcium Medicine & Life Sciences

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Projects 1985 2020

San Antonio Biomedical Education and Research

Oyajobi, B., Lechleiter, J. D., McManus, L. M. & Mcmanus, L. M.

National Institutes of Health

7/1/153/31/20

Project: Research projectPhysician Scientist Award (Program) (PSA)

education
health science
pedagogics
science
trainee

INSTITUTE FOR CANCER RESEARCH AND CARE

Hinck, A. P., Sarantopoulos, J., Curiel, T. J., Lafer, E. M., Weintraub, S. E., Karnad, A. B., Lechleiter, J. D., Thompson, I. M., Leach, R. J., Christy, B. A., Allred, C., Johnson, K., Padmanabhan, S., I-Tien, Y., Naylor, S., Gazitt, Y., Pollock, B. H., Mundy, G., Bonewald, L., Davis, S., Lee, E., Oishi, N., Hasty, E., Vijg, J. N. M. N., Herman, B. A., Johnson, K., Moyer, M., Windle, J., McGill, J., O'Connell, P., Clark, G., Kuhn, J., Wolf, R., Allred, D. C., Weiss, G., Boldt, D., Coltman, C. & Huang, H.

National Institutes of Health

9/1/917/31/19

Project: Research projectCenter Core Grants

Neoplasms
Research
Health
Hispanic Americans
Financial Management

PEPTIDERGIC CONTROL OF PREOCULAR TEAR FILM SECRETION

Lechleiter, J. D.

National Institutes of Health

6/24/85 → …

Project: Research projectPostdoctoral Individual National Research Service Award

ASTROCYTE ACTIVATION BY SMALL MOLECULE P2Y1 AGONISTS FOR TREATMENT OF TBI

Lechleiter, J. D.

National Institutes of Health

9/30/156/30/17

Project: Research projectSmall Business Technology Transfer (STTR) Grants - Phase I

Astrocytes
Emergency Responders
Pharmaceutical Preparations
Therapeutic Human Experimentation
Therapeutics

Regulation of the Unfolded Protein Response after Acute Brain Injury

Lechleiter, J. D.

National Institutes of Health

9/29/138/31/16

Project: Research projectExploratory/Developmental Grants

Unfolded Protein Response
Calcineurin
Brain Injuries
Phosphorylation
Protein Biosynthesis

Research Output 1984 2018

  • 5133 Citations
  • 33 h-Index
  • 69 Article
  • 1 Chapter
  • 1 Conference contribution
1 Citations

Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment

Van Skike, C. E., Jahrling, J. B., Olson, A. B., Sayre, N. L., Hussong, S. A., Ungvari, Z., Lechleiter, J. D. & Galvan, V., Apr 1 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 4, p. H693-H703

Research output: Contribution to journalArticle

Sirolimus
Blood-Brain Barrier
Blood Vessels
Alzheimer Disease
Cognitive Dysfunction

The long-term effect of maternal dietary protein restriction on 5-HT1A receptor function and behavioral responses to stress in adulthood

Ye, W., Pitlock, M. D., Javors, M. A., Thompson, B. J., Lechleiter, J. D. & Hensler, J. G., Jan 1 2018, (Accepted/In press) In : Behavioural Brain Research.

Research output: Contribution to journalArticle

Protein-Restricted Diet
Receptor, Serotonin, 5-HT1A
Dietary Proteins
Mothers
Psychiatry
2 Citations

Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation

Etzler, J. C., Bollo, M., Holstein, D., Deng, J. J., Perez, V., Lin, D. T., Richardson, A., Bai, Y. & Lechleiter, J. D., Jan 1 2017, In : Archives of Biochemistry and Biophysics. 613, p. 61-68 8 p.

Research output: Contribution to journalArticle

Electron Transport Complex III
Mitochondria
HEK293 Cells
Mitochondrial Proteins
Cells

Thyroid Hormone Stimulation of Adult Brain Fatty Acid Oxidation

Sifuentes, M. M. & Lechleiter, J. D., 2017, (Accepted/In press) In : Vitamins and Hormones.

Research output: Contribution to journalArticle

Thyroid Hormones
Fatty Acids
Brain
Astrocytes
Brain Injuries
5 Citations

Calcineurin β protects brain after injury by activating the unfolded protein response

Chen, Y., Holstein, D. M., Aime, S., Bollo, M. & Lechleiter, J. D., Oct 1 2016, In : Neurobiology of Disease. 94, p. 139-156 18 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Calcineurin
Astrocytes
Brain Injuries
Sarcoplasmic Reticulum Calcium-Transporting ATPases

Press/Media

Drug for concussion, stroke moves toward human trials

James D Lechleiter

7/24/17

1 item of media coverage

Press/Media: Press / Media

Drug for concussion, stroke found by UT scientist moves closer...

James D Lechleiter

7/17/177/18/17

2 items of media coverage

Press/Media: Press / Media

To Curb Brain Damage, Astrocyte Pharmaceuticals Energizes Cells

James D Lechleiter

10/19/15

1 item of media coverage

Press/Media: Press / Media