Hong Zan

  • 2650 Citations
  • 31 h-Index
19982020

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Article
2020

B cell endosomal RAB7 promotes TRAF6 K63 polyubiquitination and NF-κB activation for antibody class-switching

Yan, H., Fernandez, M., Wang, J., Wu, S., Wang, R., Lou, Z., Moroney, J. B., Rivera, C. E., Taylor, J. R., Gan, H., Zan, H., Kolvaskyy, D., Liu, D., Casali, P. & Xu, Z., Mar 1 2020, In : Journal of Immunology. 204, 5, p. 1146-1157 12 p.

Research output: Contribution to journalArticle

B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

Sanchez, H. N., Moroney, J. B., Gan, H., Shen, T., Im, J. L., Li, T., Taylor, J. R., Zan, H. & Casali, P., Dec 1 2020, In : Nature communications. 11, 1, 60.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response

Gan, H., Shen, T., Chupp, D. P., Taylor, J. R., Sanchez, H. N., Li, X., Xu, Z., Zan, H. & Casali, P., Apr 1 2020, In : Science Advances. 6, 14, eaay2793.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a

Casali, P., Shen, T., Xu, Y., Qiu, Z., Chupp, D. P., Im, J., Xu, Z. & Zan, H., Mar 24 2020, In : Frontiers in immunology. 11, 491.

Research output: Contribution to journalArticle

Open Access
2017
1 Scopus citations

Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination

Zan, H., Tat, C., Qiu, Z., Taylor, J. R., Guerrero, J. A., Shen, T. & Casali, P., Feb 8 2017, In : Nature Communications. 8, 14244.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Small molecule inhibition of Rab7 impairs B cell class switching and plasma cell survival to dampen the autoantibody response in murine lupus

Lam, T., Kulp, D. V., Wang, R., Lou, Z., Taylor, J., Rivera, C. E., Yan, H., Zhang, Q., Wang, Z., Zan, H., Ivanov, D. N., Zhong, G., Casali, P. & Xu, Z., Nov 15 2016, In : Journal of Immunology. 197, 10, p. 3792-3805 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015
16 Scopus citations
2014

Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and blimp-1 expression for epigenetic modulation of antibody and autoantibody responses

White, C. A., Pone, E. J., Lam, T., Tat, C., Hayama, K. L., Li, G., Zan, H. & Casali, P., Dec 15 2014, In : Journal of Immunology. 193, 12, p. 5933-5950 18 p.

Research output: Contribution to journalArticle

50 Scopus citations
2013

Combinatorial H3K9acS10ph histone modification in igh locus s regions targets 14-3-3 adaptors and aid to specify antibody class-switch DNA recombination

Li, G., White, C. A., Lam, T., Pone, E. J., Tran, D. C., Hayama, K. L., Zan, H., Xu, Z. & Casali, P., Oct 28 2013, In : Cell Reports. 5, 3, p. 702-714 13 p.

Research output: Contribution to journalArticle

30 Scopus citations
2012

BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

Pone, E. J., Zhang, J., Mai, T., White, C. A., Li, G., Sakakura, J. K., Patel, P. J., Al-Qahtani, A., Zan, H., Xu, Z. & Casali, P., 2012, In : Nature communications. 3, 767.

Research output: Contribution to journalArticle

119 Scopus citations

Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination

Zan, H., White, C. A., Thomas, L. M., Mai, T., Li, G., Xu, Z., Zhang, J. & Casali, P., Nov 29 2012, In : Cell Reports. 2, 5, p. 1220-1232 13 p.

Research output: Contribution to journalArticle

26 Scopus citations
2011

AID dysregulation in lupus-prone MRL/Fas lpr/lpr mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: Modulation by HoxC4

White, C. A., Seth Hawkins, J., Pone, E. J., Yu, E. S., Al-Qahtani, A., Mai, T., Zan, H. & Casali, P., Dec 1 2011, In : Autoimmunity. 44, 8, p. 585-598 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

B cell TLRs and induction of immunoglobulin class-switch DNA recombination

Pone, E. J., Xu, Z., White, C. A., Zan, H. & Casali, P., Jun 1 2011, In : Frontiers in Bioscience. 17, 7, p. 2594-2615 22 p.

Research output: Contribution to journalArticle

30 Scopus citations

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions

Zan, H., Zhang, J., Al-Qahtani, A., Pone, E. J., White, C. A., Lee, D., Yel, L., Mai, T. & Casali, P., Jan 1 2011, In : Molecular Immunology. 48, 4, p. 610-622 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Three fatal cases of pandemic 2009 influenza A virus infection in Shenzhen are associated with cytokine storm

Cheng, X. W., Lu, J., Wu, C. L., Yi, L. N., Xie, X., Shi, X. D., Fang, S. S., Zan, H., Kung, H. F. & He, M. L., Jan 31 2011, In : Respiratory Physiology and Neurobiology. 175, 1, p. 185-187 3 p.

Research output: Contribution to journalArticle

31 Scopus citations

Viral kinetics of Enterovirus 71 in human habdomyosarcoma cells

Lu, J., He, Y. Q., Yi, L. N., Zan, H., Kung, H. F. & He, M. L., Sep 28 2011, In : World Journal of Gastroenterology. 17, 36, p. 4135-4142 8 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations
2010

14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination

Xu, Z., Fulop, Z., Wu, G., Pone, E. J., Zhang, J., Mai, T., Thomas, L. M., Al-Qahtani, A., White, C. A., Park, S. R., Steinacker, P., Li, Z., Yates, J., Herron, B., Otto, M., Zan, H., Fu, H. & Casali, P., Sep 1 2010, In : Nature Structural and Molecular Biology. 17, 9, p. 1124-1135 12 p.

Research output: Contribution to journalArticle

95 Scopus citations
56 Scopus citations

Specific cross-reaction of anti-dsDNA antibody with platelet integrin GPIIIa49-66

Zhang, W., Dang, S., Wang, J., Nardi, M. A., Zan, H., Casali, P. & Li, Z., Dec 1 2010, In : Autoimmunity. 43, 8, p. 682-689 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2009

HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

Park, S. R., Zan, H., Pal, Z., Zhang, J., Al-Qahtani, A., Pone, E. J., Xu, Z., Mai, T. & Casali, P., 2009, In : Nature Immunology. 10, 5, p. 540-550 11 p.

Research output: Contribution to journalArticle

91 Scopus citations
38 Scopus citations
2008
20 Scopus citations

A role for DRAK2 in the germinal center reaction and the antibody response

Al-Qahtani, A., Xu, Z., Zan, H., Walsh, C. & Casali, P., Jul 1 2008, In : Autoimmunity. 41, 5, p. 341-352 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2006

A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation

Wu, X., Tsai, C. Y., Patam, M. B., Zan, H., Chen, J. P., Lipkin, S. M. & Casali, P., May 1 2006, In : Journal of Immunology. 176, 9, p. 5426-5437 12 p.

Research output: Contribution to journalArticle

30 Scopus citations
9 Scopus citations
2005

DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation

Xu, Z., Fulop, Z., Zhong, Y., Evincer, A. J., Zan, H. & Casali, P., Jan 1 2005, In : Annals of the New York Academy of Sciences. 1050, p. 146-162 17 p.

Research output: Contribution to journalArticle

44 Scopus citations

The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation

Zan, H., Shima, N., Xu, Z., Al-Qahtani, A., Evinger, A. J., Zhong, Y., Schimenti, J. C. & Casali, P., Nov 2 2005, In : EMBO Journal. 24, 21, p. 3757-3769 13 p.

Research output: Contribution to journalArticle

96 Scopus citations
2003

AID-Dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in Somatic hypermutation

Zan, H., Wu, X., Komori, A., Holloman, W. K. & Casali, P., Jun 1 2003, In : Immunity. 18, 6, p. 727-738 12 p.

Research output: Contribution to journalArticle

79 Scopus citations

Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements

Schaffer, A., Kim, E. C., Wu, X., Zan, H., Testoni, L., Salamon, S., Cerutti, A. & Casali, P., Jun 20 2003, In : Journal of Biological Chemistry. 278, 25, p. 23141-23150 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
2002

Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin VHDJH gene diversification

Gurrieri, C., McGuire, P., Zan, H., Yan, X. J., Cerutti, A., Albesiano, E., Allen, S. L., Vinciguerra, V., Rai, K. R., Ferrarini, M., Casali, P. & Chiorazzi, N., Sep 2002, In : Journal of Experimental Medicine. 196, 5, p. 629-639 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells

Cerutti, A., Zan, H., Kim, E. C., Shah, S., Schattner, E. J., Schaffer, A. & Casali, P., Dec 1 2002, In : Journal of Immunology. 169, 11, p. 6594-6603 10 p.

Research output: Contribution to journalArticle

60 Scopus citations
2001

Dysregulation of CD30+T cells by leukemia impairs isotype switching in normal B cells

Cerutti, A., Kim, E. C., Shah, S., Schattner, E. J., Zan, H., Schaffer, A. & Casali, P., Feb 1 2001, In : Nature Immunology. 2, 2, p. 150-156 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

The translesion DNA polymerase ζ plays a major role in Ig and bcl-6 somatic hypermutation

Zan, H., Komori, A., Li, Z., Cerutti, A., Schaffer, A., Flajnik, M. F., Diaz, M. & Casali, P., Jan 1 2001, In : Immunity. 14, 5, p. 643-653 11 p.

Research output: Contribution to journalArticle

186 Scopus citations
2000

B cell receptor engagement and T cell contact induce bcl-6 somatic hypermutation in human B cells: Identity with Ig hypermutation

Zan, H., Li, Z., Yamaji, K., Dramitinos, P., Cerutti, A. & Casali, P., Jul 15 2000, In : Journal of Immunology. 165, 2, p. 830-839 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells

Cerutti, A., Schaffer, A., Goodwin, R. G., Shah, S., Zan, H., Ely, S. & Casali, P., Jul 15 2000, In : Journal of Immunology. 165, 2, p. 786-794 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

Ongoing hypermutation in the Ig V(D)J gene segments and c-myc proto-oncogene of an AIDS lymphoma segregates with neoplastic B cells at different sites: Implications for clonal evolution

Ikematsu, H., Cerutti, A., Zan, H., Knowles, D. M., Ikematsu, W. & Casali, P., Dec 1 2000, In : Human Immunology. 61, 12, p. 1242-1253 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
1999

Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: Definition of the requirements and modalities of hypermutation

Zan, H., Cerutti, A., Dramitinos, P., Schaffer, A., Li, Z. & Casali, P., Mar 15 1999, In : Journal of Immunology. 162, 6, p. 3437-3447 11 p.

Research output: Contribution to journalArticle

86 Scopus citations
48 Scopus citations
1998
1 Scopus citations

CD30 is a CD40-inducible molecule that negatively regulates CD40- mediated immunoglobulin class switching in non-antigen-selected human B cells

Cerutti, A., Schaffer, A., Shah, S., Zan, H., Liou, H. C., Goodwin, R. G. & Casali, P., Aug 1998, In : Immunity. 9, 2, p. 247-256 10 p.

Research output: Contribution to journalArticle

63 Scopus citations
129 Scopus citations

CD40 ligand and appropriate cytokines induce switching to IgG, IgA, and IgE and coordinated germinal center and plasmacytoid phenotypic differentiation in a human monoclonal IgM+ IgD+ B cell line

Cerutti, A., Zan, H., Schaffer, A., Bergsagel, L., Harindranath, N., Max, E. E. & Casali, P., Mar 1 1998, In : Journal of Immunology. 160, 5, p. 2145-2157 13 p.

Research output: Contribution to journalArticle

165 Scopus citations

The ECS-Iγ 3 sequence upstream of the human Ig Sγ 3 region is a functional promoter. Synergistic activation by CD40L and IL-4 via distinct cis regulatory elements

Schaffer, A., Zan, H., Cerutti, A., Max, E. E. & Casali, P., Mar 20 1998, In : FASEB Journal. 12, 5, p. A1058

Research output: Contribution to journalArticle

1 Scopus citations