• 7836 Citations
  • 50 h-Index
1988 …2019
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Research Output 1988 2019

  • 7836 Citations
  • 50 h-Index
  • 214 Article
  • 3 Chapter
  • 1 Review article
2019

Antigen-specific CD4 T cell-derived gamma interferon is both necessary and sufficient for clearing chlamydia from the small intestine but not the large intestine

Lin, H., He, C., Koprivsek, J. J., Chen, J., Zhou, Z., Arulanandam, B., Xu, Z., Tang, L. & Zhong, G., Jan 1 2019, In : Infection and Immunity. 87, 6, e00055-19.

Research output: Contribution to journalArticle

CD4 Antigens
Chlamydia
Large Intestine
Interferon-gamma
Small Intestine

A primary study on genes with selected mutations by in vitro passage of Chlamydia muridarum strains

Zhou, Z., Liu, N., Wang, Y., Emmanuel, A. W., You, X., Liu, J., Li, Z., Wu, Y. & Zhong, G., Apr 1 2019, In : Pathogens and disease. 77, 3

Research output: Contribution to journalArticle

Chlamydia muridarum
Mutation
Genes
Chlamydia
Point Mutation
1 Citation (Scopus)

Chlamydia muridarum induces pathology in the female upper genital tract via distinct mechanisms

Yu, H., Lin, H., Xie, L., Tang, L., Chen, J., Zhou, Z., Ni, J. & Zhong, G., Jan 1 2019, In : Infection and Immunity. 87, 8, e00145.

Research output: Contribution to journalArticle

Chlamydia muridarum
Pathology
T-Lymphocytes
Virulence
Inbred C57BL Mouse

Distinct roles of chromosome- versus plasmid-encoded genital tract virulence factors in promoting chlamydia muridarum colonization in the gastrointestinal tract

Koprivsek, J. J., Zhang, T., Tian, Q., He, Y., Xu, H., Xu, Z. & Zhong, G., Jan 1 2019, In : Infection and Immunity. 87, 8, e00265.

Research output: Contribution to journalArticle

Chlamydia muridarum
Virulence Factors
Gastrointestinal Tract
Colon
Plasmids

IL-10通过抑制IFN-γ和IL-2表达促进鼠衣原体感染

Translated title of the contribution: IL-10 promotes Chlamydia muridarum infection in mice through inhibiting IFN-γ and IL-2 expressionHe, Q., He, M., Wang, X., Luo, X., Wu, Y. & Zhong, G., Feb 28 2019, In : Chinese Journal of Microbiology and Immunology (China). 39, 2, p. 126-130 5 p.

Research output: Contribution to journalArticle

Chlamydia muridarum
Chlamydia Infections
Interleukin-10
Interleukin-2
Gene Knockout Techniques
2 Citations (Scopus)

The plasmid-encoded PGP3 promotes chlamydia evasion of acidic barriers in both stomach and vagina

Zhang, T., Huo, Z., Ma, J., He, C. & Zhong, G., May 1 2019, In : Infection and Immunity. 87, 5, e00844-18.

Research output: Contribution to journalArticle

Chlamydia muridarum
Chlamydia
Vagina
Stomach
Plasmids
2 Citations (Scopus)

TIM-4 inhibits NLRP3 inflammasome via the LKB1/AMPKA pathway in macrophages

Liu, W., Bai, F., Wang, H., Liang, Y., Du, X., Liu, C., Cai, D., Peng, J., Zhong, G., Liang, X., Ma, C. & Gao, L., Aug 15 2019, In : Journal of Immunology. 203, 4, p. 990-1000 11 p.

Research output: Contribution to journalArticle

Inflammasomes
Macrophages
Liver
Phosphatidylserines
Autophagy
2018
3 Citations (Scopus)

Advances and obstacles in the genetic dissection of chlamydial virulence

Brothwell, J. A., Muramatsu, M. K., Zhong, G. & Nelson, D. E., Jan 1 2018, Current Topics in Microbiology and Immunology. Springer Verlag, p. 133-158 26 p. (Current Topics in Microbiology and Immunology; vol. 412).

Research output: Chapter in Book/Report/Conference proceedingChapter

Chlamydia
Virulence
Dissection
Genes
Chlamydiaceae
3 Citations (Scopus)

Chlamydial plasmid-encoded virulence factor Pgp3 interacts with human cathelicidin peptide LL-37 to modulate immune response

Hou, S., Sun, X., Dong, X., Lin, H., Tang, L., Xue, M. & Zhong, G., Jan 1 2018, (Accepted/In press) In : Microbes and Infection.

Research output: Contribution to journalArticle

Virulence Factors
Neutrophils
Plasmids
Epithelial Cells
Peptides
6 Citations (Scopus)

Nonpathogenic colonization with Chlamydia in the gastrointestinal tract as oral vaccination for inducing transmucosal protection

Wang, L., Zhu, C., Zhang, T., Tian, Q., Zhang, N., Morrison, S., Morrison, R., Xue, M. & Zhong, G., Feb 1 2018, In : Infection and Immunity. 86, 2, e00630-17.

Research output: Contribution to journalArticle

Chlamydia muridarum
Chlamydia
Gastrointestinal Tract
Vaccination
Reproductive Tract Infections
4 Citations (Scopus)

Oral Chlamydia vaccination induces transmucosal protection in the airway

Zhu, C., Lin, H., Tang, L., Chen, J., Wu, Y. & Zhong, G., Apr 12 2018, In : Vaccine. 36, 16, p. 2061-2068 8 p.

Research output: Contribution to journalArticle

Chlamydia muridarum
Chlamydia
oral vaccination
mouth
Vaccination
7 Citations (Scopus)

The genital tract virulence factor pGP3 is essential for Chlamydia muridarum colonization in the gastrointestinal tract

Shao, L., Zhang, T., Melero, J., Huang, Y., Liu, Y., Liu, Q., He, C., Nelson, D. E. & Zhong, G., Jan 1 2018, In : Infection and Immunity. 86, 1, e00429-17.

Research output: Contribution to journalArticle

Chlamydia muridarum
Virulence Factors
Gastrointestinal Tract
Plasmids
Reproductive Tract Infections
3 Citations (Scopus)

Transcervical inoculation with Chlamydia trachomatis induces infertility in HLA-DR4 transgenic and wild-type mice

Pal, S., Tifrea, D. F., Zhong, G. & de la Maza, L. M., Jan 1 2018, In : Infection and Immunity. 86, 1, e00722-17.

Research output: Contribution to journalArticle

Chlamydia trachomatis
HLA Antigens
Infertility
Transgenic Mice
Vaccines
2017

2017: Beginning of a new era for Chlamydia research in China and the rest of the world

Fan, H. & Zhong, G., 2017, (Accepted/In press) In : Microbes and Infection.

Research output: Contribution to journalArticle

Chlamydia
China
Research
Chlamydia trachomatis
Disclosure
10 Citations (Scopus)

Chlamydial lipoproteins stimulate toll-like receptors 1/2 mediated inflammatory responses through MyD88-dependent pathway

Wang, Y., Liu, Q., Chen, D., Guan, J., Ma, L., Zhong, G., Shu, H. & Wu, X., Jan 26 2017, In : Frontiers in Microbiology. 8, JAN, 78.

Research output: Contribution to journalArticle

Toll-Like Receptor 1
Toll-Like Receptor 2
Lipoproteins
Toll-Like Receptors
Chlamydia trachomatis
3 Citations (Scopus)

Chlamydial protease-like activity factor mediated protection against C. trachomatis in guinea pigs

Wali, S., Gupta, R., Yu, J. J., Lanka, G. K. K., Chambers, J. P., Guentzel, M. N., Zhong, G., Murthy, A. K. & Arulanandam, B. P., May 1 2017, In : Immunology and Cell Biology. 95, 5, p. 454-460 7 p.

Research output: Contribution to journalArticle

Guinea Pigs
Peptide Hydrolases
Immunization
Animal Models
Infection
10 Citations (Scopus)

Chlamydia muridarum with mutations in chromosomal genes tc0237 and/or tc0668 is deficient in colonizing the mouse gastrointestinal tract

Shao, L., Zhang, T., Liu, Q., Wang, J. & Zhong, G., Aug 1 2017, In : Infection and Immunity. 85, 8, e00321-17.

Research output: Contribution to journalArticle

Chlamydia muridarum
Gastrointestinal Tract
Mutation
Virulence
Genes
7 Citations (Scopus)

Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract - A Two-Hit Hypothesis

Zhong, G., Jan 1 2017, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

Chlamydia muridarum
Chlamydia
Gastrointestinal Tract
Chlamydia trachomatis
Fibrosis

CPAF selectively degrades chlamydial T cell antigens for inhibiting antigen presentation

Zhang, Y., Zhong, G., Cai, H., Chen, S., Sun, D., Zhang, D. & He, Y., Nov 1 2017, In : Journal of Infection in Developing Countries. 11, 11, p. 868-875 8 p.

Research output: Contribution to journalArticle

Chlamydia
Viral Tumor Antigens
Antigen Presentation
T-Lymphocytes
Bacterial Sexually Transmitted Diseases
7 Citations (Scopus)

IL-6-mediated signaling pathways limit Chlamydia muridarum infection and exacerbate its pathogenicity in the mouse genital tract

Sun, X., Tian, Q., Wang, L., Xue, M. & Zhong, G., Nov 1 2017, In : Microbes and Infection. 19, 11, p. 536-545 10 p.

Research output: Contribution to journalArticle

Chlamydia muridarum
Chlamydia Infections
Virulence
Interleukin-6
Infection
5 Citations (Scopus)

National institute of allergy and infectious diseases workshop report: “Chlamydia vaccines: The way forward“

Zhong, G., Brunham, R. C., de la Maza, L. M., Darville, T. & Deal, C., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

National Institute of Allergy and Infectious Diseases (U.S.)
Chlamydia trachomatis
Chlamydia
hypersensitivity
infectious diseases
12 Citations (Scopus)

The cryptic plasmid is more important for Chlamydia muridarum to colonize the mouse gastrointestinal tract than to infect the genital tract

Shao, L., Melero, J., Zhang, N., Arulanandam, B., Baseman, J., Liu, Q. & Zhong, G., May 1 2017, In : PLoS One. 12, 5, e0177691.

Research output: Contribution to journalArticle

Chlamydia muridarum
genitalia
gastrointestinal system
Gastrointestinal Tract
plasmids
24 Citations (Scopus)

Update on Chlamydia trachomatis vaccinology

De La Maza, L. M., Zhong, G. & Brunham, R. C., Apr 1 2017, In : Clinical and Vaccine Immunology. 24, 4, 0054316.

Research output: Contribution to journalReview article

Chlamydia trachomatis
Vaccines
Immunization
Trachoma
Chlamydia
1 Citation (Scopus)

Uterotubal junction prevents chlamydial ascension via innate immunity

Zhang, Y., Shao, L., Li, X-D. & Zhong, G., Aug 1 2017, In : PLoS One. 12, 8, e0183189.

Research output: Contribution to journalArticle

Chlamydia muridarum
Ascension
Pathology
Innate Immunity
Oviducts
2016
3 Citations (Scopus)

An optimized, fast-to-perform mouse lung infection model with the human pathogen Chlamydia trachomatis for in vivo screening of antibiotics, vaccine candidates and modified host-pathogen interactions

Dutow, P., Wask, L., Bothe, M., Fehlhaber, B., Laudeley, R., Rheinheimer, C., Yang, Z., Zhong, G., Glage, S. & Klos, A., Mar 1 2016, In : Pathogens and Disease. 74, 2

Research output: Contribution to journalArticle

Host-Pathogen Interactions
Chlamydia trachomatis
Vaccines
Anti-Bacterial Agents
Lung
31 Citations (Scopus)

Chlamydial Plasmid-Dependent Pathogenicity

Zhong, G., 2016, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

Virulence
Plasmids
Chlamydia
Genes
Chlamydia trachomatis
2 Citations (Scopus)

Guinea pig genital tract lipidome reveals in vivo and in vitro regulation of phosphatidylcholine 16: 0/18:1 and contribution to Chlamydia trachomatis serovar D infectivity

Wali, S., Gupta, R., Yu, J. J., Mfuh, A., Gao, X., Guentzel, M. N., Chambers, J. P., Bakar, S. A., Zhong, G. & Arulanandam, B. P., Apr 1 2016, In : Metabolomics. 12, 4, 74.

Research output: Contribution to journalArticle

Chlamydia trachomatis
Phosphatidylcholines
Guinea Pigs
Metabolites
Chlamydia Infections
2 Citations (Scopus)

IgA modulates respiratory dysfunction as a sequela to pulmonary chlamydial infection as neonates

Lanka, G. K. K., Yu, J. J., Gong, S., Gupta, R., Mustafa, S. B., Murthy, A. K., Zhong, G., Chambers, J. P., Guentzel, M. N. & Arulanandam, B. P., Apr 1 2016, In : Pathogens and Disease. 74, 3

Research output: Contribution to journalArticle

Immunoglobulin A
Newborn Infant
Lung
Infection
Chlamydia Infections
13 Citations (Scopus)

Intravenous inoculation with chlamydia muridarum leads to a long-lasting infection restricted to the gastrointestinal tract

Dai, J., Zhang, T., Wang, L., Shao, L., Zhu, C., Zhang, Y., Failor, C., Schenken, R. S., Baseman, J., He, C. & Zhong, G., 2016, In : Infection and Immunity. 84, 8, p. 2382-2388 7 p.

Research output: Contribution to journalArticle

Chlamydia muridarum
Gastrointestinal Tract
Infection
Luciferases
Veins
13 Citations (Scopus)

Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF

Yang, Z., Tang, L., Zhou, Z. & Zhong, G., Nov 1 2016, In : Microbes and Infection. 18, 11, p. 669-674 6 p.

Research output: Contribution to journalArticle

Complement C3
Chlamydia
Chlamydia trachomatis
Peptide Hydrolases
Alternative Complement Pathway
4 Citations (Scopus)

Small molecule inhibition of Rab7 impairs B cell class switching and plasma cell survival to dampen the autoantibody response in murine lupus

Lam, T., Kulp, D. V., Wang, R., Lou, Z., Taylor, J., Rivera, C. E., Yan, H., Zhang, Q., Wang, Z., Zan, H., Ivanov, D. N., Zhong, G., Casali, P. & Xu, Z., Nov 15 2016, In : Journal of Immunology. 197, 10, p. 3792-3805 14 p.

Research output: Contribution to journalArticle

Immunoglobulin Class Switching
Plasma Cells
Autoantibodies
Cell Survival
B-Lymphocytes
14 Citations (Scopus)

The Chlamydia muridarum organisms fail to auto-inoculate the mouse genital tract after colonization in the gastrointestinal tract for 70 days

Wang, L., Zhang, Q., Zhang, T., Zhang, Y., Zhu, C., Sun, X., Zhang, N., Xue, M. & Zhong, G., May 1 2016, In : PLoS One. 11, 5, e0155880.

Research output: Contribution to journalArticle

Chlamydia muridarum
automobiles
genitalia
gastrointestinal system
Gastrointestinal Tract
2015
15 Citations (Scopus)

Characterization of CPAF critical residues and secretion during Chlamydia trachomatis infection

Yang, Z., Tang, L., Sun, X., Chai, J. & Zhong, G., 2015, In : Infection and Immunity. 83, 6, p. 2234-2241 8 p.

Research output: Contribution to journalArticle

Chlamydia Infections
Chlamydia trachomatis
Peptide Hydrolases
Dimerization
Cell-Free System
23 Citations (Scopus)

Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37

Hou, S., Dong, X., Yang, Z., Li, Z., Liu, Q. & Zhong, G., 2015, In : Infection and Immunity. 83, 12, p. 4701-4709 9 p.

Research output: Contribution to journalArticle

Virulence Factors
Human Activities
Plasmids
Chlamydia trachomatis
Pathology
5 Citations (Scopus)

Chlamydia muridarum induction of glandular duct dilation in mice

Sun, X., Yang, Z., Zhang, H., Dai, J., Chen, J., Tang, L., Rippentrop, S., Xue, M., Zhong, G. & Wu, G., 2015, In : Infection and Immunity. 83, 6, p. 2327-2337 11 p.

Research output: Contribution to journalArticle

Chlamydia muridarum
Dilatation
Chlamydia Infections
Chlamydia
Myometrium
26 Citations (Scopus)

Chlamydia-secreted protease CPAF degrades host antimicrobial peptides

Tang, L., Chen, J., Zhou, Z., Yu, P., Yang, Z. & Zhong, G., 2015, In : Microbes and Infection. 17, 6, p. 402-408 7 p.

Research output: Contribution to journalArticle

Chlamydia
Chlamydia trachomatis
Peptide Hydrolases
Peptides
Chlamydia Infections
13 Citations (Scopus)

Effect of pH on cleavage of glycogen by vaginal enzymes

Spear, G. T., McKenna, M., Landay, A. L., Makinde, H., Hamaker, B., French, A. L., Lee, B. H. & Zhong, G., Jul 14 2015, In : PLoS One. 10, 7

Research output: Contribution to journalArticle

Glycogen
glycogen
Amylases
genitalia
amylases
3 Citations (Scopus)

Identification of plasmid-free chlamydia muridarum organisms using a pgp3 detection-based immunofluorescence assay

Chen, C., Zhong, G., Ren, L., Lu, C., Li, Z. & Wu, Y., 2015, In : Journal of Microbiology and Biotechnology. 25, 10, p. 1621-1628 8 p., A006.

Research output: Contribution to journalArticle

Chlamydia muridarum
Fluorescent Antibody Technique
Plasmids
Clone Cells
Novobiocin
16 Citations (Scopus)

Infection with Chlamydia pneumoniae as a cause of coronary heart disease: The hypothesis is still untested

Grayston, J. T., Belland, R. J., Byrne, G. I., Kuo, C. C., Schachter, J., Stamm, W. E. & Zhong, G., 2015, In : Pathogens and Disease. 73, 1, ftu015.

Research output: Contribution to journalArticle

Chlamydophila Infections
Chlamydophila pneumoniae
Preschool Children
Coronary Disease
Young Adult
15 Citations (Scopus)

Intrauterine infection with plasmid-free Chlamydia muridarum reveals a critical role of the plasmid in chlamydial ascension and establishes a model for evaluating plasmid-independent pathogenicity

Chen, J., Yang, Z., Sun, X., Tang, L., Ding, Y., Xue, M., Zhou, Z., Baseman, J. & Zhong, G., 2015, In : Infection and Immunity. 83, 6, p. 2583-2592 10 p.

Research output: Contribution to journalArticle

Chlamydia muridarum
Virulence
Plasmids
Inbred CBA Mouse
Infection
25 Citations (Scopus)

In vitro passage selects for Chlamydia muridarum with enhanced infectivity in cultured cells but attenuated pathogenicity in mouse upper genital tract

Chen, C., Zhou, Z., Conrad, T., Yang, Z., Dai, J., Li, Z., Wu, Y. & Zhong, G., 2015, In : Infection and Immunity. 83, 5, p. 1881-1892 12 p.

Research output: Contribution to journalArticle

Chlamydia muridarum
Serial Passage
Virulence
Cultured Cells
Population
30 Citations (Scopus)

In vivo and ex vivo imaging reveals a long-lasting chlamydial infection in the mouse gastrointestinal tract following genital tract inoculation

Zhang, Q., Huang, Y., Gong, S., Yang, Z., Sun, X., Schenken, R. S. & Zhong, G., 2015, In : Infection and Immunity. 83, 9, p. 3568-3577 10 p.

Research output: Contribution to journalArticle

Chlamydia muridarum
Gastrointestinal Tract
Infection
Chlamydia Infections
Infertility
17 Citations (Scopus)

Plasmid-encoded Pgp5 is a significant contributor to Chlamydia muridarum induction of hydrosalpinx

Huang, Y., Zhang, Q., Yang, Z., Conrad, T., Liu, Y. & Zhong, G., Apr 27 2015, In : PLoS One. 10, 4, e0124840.

Research output: Contribution to journalArticle

Chlamydia muridarum
plasmids
Plasmids
Virulence Factors
Oviducts
6 Citations (Scopus)
Chlamydophila pneumoniae
Cell signaling
Wnt Signaling Pathway
Catenins
membrane proteins
21 Citations (Scopus)

The chromosome-encoded hypothetical protein TC0668 is an upper genital tract pathogenicity factor of Chlamydia muridarum

Conrad, T. A., Gong, S., Yang, Z., Matulich, P., Keck, J., Beltrami, N., Chen, C., Zhou, Z., Dai, J. & Zhong, G., 2015, In : Infection and Immunity. 84, 2, p. 467-479 13 p.

Research output: Contribution to journalArticle

Chlamydia muridarum
Virulence Factors
Chromosomes
Missense Mutation
Proteins
6 Citations (Scopus)

The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues

Dai, J., Tang, L., Chen, J., Yu, P., Chen, Z. & Zhong, G., Sep 9 2015, (Accepted/In press) In : Microbes and Infection.

Research output: Contribution to journalArticle

Chlamydia muridarum
Oviducts
Virulence
NADP
Oxidoreductases
2014
17 Citations (Scopus)

Bioluminescence imaging of Chlamydia muridarum ascending infection in mice

Campbell, J., Huang, Y., Liu, Y., Schenken, R. S., Arulanandam, B. & Zhong, G., Jul 1 2014, In : PLoS One. 9, 7, e101634.

Research output: Contribution to journalArticle

Chlamydia muridarum
Bioluminescence
bioluminescence
genitalia
image analysis
37 Citations (Scopus)

Chlamydial induction of hydrosalpinx in 11 strains of mice reveals multiple host mechanisms for preventing upper genital tract pathology

Chen, J., Zhang, H., Zhou, Z., Yang, Z., Ding, Y., Zhou, Z., Zhong, E., Arulanandam, B., Baseman, J. & Zhong, G., Apr 15 2014, In : PLoS One. 9, 4, e95076.

Research output: Contribution to journalArticle

Pathology
genitalia
Ascension
mice
Infection

Chlamydia trachomatis

Fan, H. & Zhong, G., Nov 26 2014, Molecular Medical Microbiology: Second Edition. Elsevier Ltd, Vol. 3. p. 1449-1469 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chlamydia trachomatis
Genes
Plasmids
Small Untranslated RNA
Pelvic Inflammatory Disease
19 Citations (Scopus)

Complement factor C5 but not C3 contributes significantly to hydrosalpinx development in mice infected with Chlamydia muridarum

Yang, Z., Conrad, T., Zhou, Z., Chen, J., Dutow, P., Klos, A. & Zhong, G., 2014, In : Infection and Immunity. 82, 8, p. 3154-3163 10 p.

Research output: Contribution to journalArticle

Chlamydia muridarum
Complement C5
Oviducts
Infection