Christi A Walter

  • 3320 Citations
  • 29 h-Index
1989 …2020

Research output per year

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Research Output

  • 3320 Citations
  • 29 h-Index
  • 79 Article
  • 3 Review article
  • 1 Conference contribution
2020

The splicing component ISY1 regulates APE1 in base excision repair

Jaiswal, A. S., Williamson, E. A., Srinivasan, G., Kong, K., Lomelino, C. L., McKenna, R., Walter, C., Sung, P., Narayan, S. & Hromas, R., Feb 2020, In : DNA Repair. 86, 102769.

Research output: Contribution to journalArticle

Open Access
2019

C3HeB/FeJ Mice mimic many aspects of gene expression and pathobiological features of human hepatocellular carcinoma

Zavadil, J. A., Herzig, M. C. S., Hildreth, K., Foroushani, A., Boswell, W., Walter, R., Reddick, R., White, H., Zare, H. & Walter, C. A., Mar 2019, In : Molecular Carcinogenesis. 58, 3, p. 309-320 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Fluorescent Light Incites a Conserved Immune and Inflammatory Genetic response within Vertebrate Organs (Danio Rerio, Oryzias Latipes and Mus Musculus)

Boswell, M., Lu, Y., Boswell, W., Savage, M., Hildreth, K., Salinas, R., Walter, C. A. & Walter, R. B., Apr 2019, In : Genes. 10, 4, 271.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Ligase 3–mediated end-joining maintains genome stability of human embryonic stem cells

Kohutova, A., Raška, J., Kruta, M., Seneklova, M., Barta, T., Fojtik, P., Jurakova, T., Walter, C. A., Hampl, A., Dvorak, P. & Rotrekl, V., Jun 1 2019, In : FASEB Journal. 33, 6, p. 6778-6788 11 p.

Research output: Contribution to journalArticle

2017

Pluripotent cells display enhanced resistance to mutagenesis

Cooper, D. J., Chen, I. C., Hernandez, C., Wang, Y., Walter, C. A. & McCarrey, J. R., Mar 1 2017, In : Stem Cell Research. 19, p. 113-117 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential

Dong, Q., Gao, H., Shi, Y., Zhang, F., Gu, X., Wu, A., Wang, D., Chen, Y., Bandyopadhyay, A., Yeh, I. T., Daniel, B. J., Chen, Y., Zou, Y., Rebel, V. L., Walter, C. A., Lu, J., Huang, C. & Sun, L. Z., 2016, In : Aging. 8, 11, p. 2754-2776 23 p.

Research output: Contribution to journalArticle

5 Scopus citations

DNA alkylating agent protects against spontaneous Hepatocellular carcinoma regardless of O6-methylguanine-DNA methyltransferase status

Herzig, M. C. S., Zavadil, J. A., Street, K., Hildreth, K., Drinkwater, N. R., Reddick, T., Herbert, D. C., Hanes, M. A., McMahan, C. A., Reddick, R. L. & Walter, C. A., Mar 2016, In : Cancer Prevention Research. 9, 3, p. 245-252 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice

Sanchez, J. R., Reddick, T. L., Perez, M., Centonze, V. E., Mitra, S., Izumi, T., McMahan, C. A. & Walter, C. A., Sep 1 2015, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 779, p. 124-133 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Co-regulation of pluripotency and genetic integrity at the genomic level

Cooper, D. J., Walter, C. A. & McCarrey, J. R., Nov 1 2014, In : Stem Cell Research. 13, 3, p. 508-519 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Early-life exposure to benzo[a]pyrene increases mutant frequency in spermatogenic cells in adulthood

Xu, G., McMahan, C. A. & Walter, C. A., Jan 29 2014, In : PloS one. 9, 1, e87439.

Research output: Contribution to journalArticle

12 Scopus citations

Identifying DNA mutations in purified hematopoietic stem/progenitor cells

Cheng, Z., Zhou, T., Merchant, A., Prihoda, T. J., Wickes, B. L., Xu, G., Walter, C. A. & Rebel, V. I., Feb 24 2014, In : Journal of Visualized Experiments. 84, e50752.

Research output: Contribution to journalArticle

Pubertal bisphenol A exposure alters murine mammary stem cell function leading to early neoplasia in regenerated glands

Wang, D., Gao, H., Bandyopadhyay, A., Wu, A., Yeh, I. T., Chen, Y., Zou, Y., Huang, C., Walter, C. A., Dong, Q. & Sun, L. Z., Apr 2014, In : Cancer Prevention Research. 7, 4, p. 445-455 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
2013

Enhanced genetic integrity in mouse germ cells

Murphey, P., McLean, D. J., McMahan, C. A., Walter, C. A. & McCarrey, J. R., Jan 1 2013, In : Biology of reproduction. 88, 1, 6.

Research output: Contribution to journalArticle

25 Scopus citations

Human O6-methylguanine-DNA methyltransferase containing C145A does not prevent hepatocellular carcinoma in C3HeB/FeJ transgenic mice

Herzig, M. C. S., Hildreth, K., Huamani, J., Perez, M., Goins, B. A., Mcmahan, C. A., Reddick, R. L. & Walter, C. A., Apr 1 2013, In : Molecular Carcinogenesis. 52, 4, p. 275-285 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mammospheres from murine mammary stem cell-enriched basal cells: Clonal characteristics and repopulating potential

Dong, Q., Wang, D., Bandyopadhyay, A., Gao, H., Gorena, K. M., Hildreth, K., Rebel, V. I., Walter, C. A., Huang, C. & Sun, L. Z., Mar 12 2013, In : Stem Cell Research. 10, 3, p. 396-404 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Myelodysplastic syndrome: An inability to appropriately respond to damaged DNA?

Zhou, T., Hasty, P., Walter, C. A., Bishop, A. J. R., Scott, L. M. & Rebel, V. I., Aug 1 2013, In : Experimental Hematology. 41, 8, p. 665-674 10 p.

Research output: Contribution to journalReview article

24 Scopus citations

TGF-β Signaling Is Often Attenuated during Hepatotumorigenesis, but Is Retained for the Malignancy of Hepatocellular Carcinoma Cells

Mu, X., Lin, S., Yang, J., Chen, C., Chen, Y., Herzig, M. C., Washburn, K., Halff, G. A., Walter, C. A., Sun, B. & Sun, L. Z., May 21 2013, In : PloS one. 8, 5, e63436.

Research output: Contribution to journalArticle

21 Scopus citations

The paternal age effect: a multifaceted phenomenon.

Momand, J. R., Xu, G. & Walter, C. A., Apr 2013, In : Unknown Journal. 88, 4

Research output: Contribution to journalReview article

11 Scopus citations
2012

Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance

Liu, M., Xiang, R., Wilk, S. A., Zhang, N., Sloane, L. B., Azarnoush, K., Zhou, L., Chen, H., Xiang, G., Walter, C. A., Austad, S. N., Musi, N., DeFronzo, R. A., Asmis, R., Scherer, P. E., Dong, L. Q. & Liu, F., Nov 1 2012, In : Diabetes. 61, 11, p. 2776-2786 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Ionizing radiation-induced mutant frequencies increase transiently in male germ cells of older mice

Xu, G., McMahan, C. A., Hildreth, K., Garcia, R. A., Herbert, D. C. & Walter, C. A., May 15 2012, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 744, 2, p. 135-139 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2011

Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice

Vogel, K. S., Perez, M., Momand, J. R., Acevedo-Torres, K., Hildreth, K., Garcia, R. A., Torres-Ramos, C. A., Ayala-Torres, S., Prihoda, T. J., Mcmahan, C. A. & Walter, C. A., Dec 1 2011, In : Molecular Reproduction and Development. 78, 12, p. 906-919 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2010

BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice

Xu, G., Vogel, K. S., McMahan, C. A., Herbert, D. C. & Walter, C. A., Dec 1 2010, In : Biology of reproduction. 83, 6, p. 979-987 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Purinergic receptor stimulation reduces cytotoxic edema and brain infarcts in mouse induced by photothrombosis by energizing glial mitochondria

Zheng, W., Watts, L. T., Holstein, D. M., Prajapati, S. I., Keller, C., Grass, E. H., Walter, C. A. & Lechleiter, J. D., 2010, In : PloS one. 5, 12, e14401.

Research output: Contribution to journalArticle

49 Scopus citations
2009

Epigenetic regulation of genetic integrity is reprogrammed during cloning

Murphey, P., Yamazaki, Y., Alex McMahan, C., Walter, C. A., Yanagimachi, R. & McCarrey, J. R., Mar 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4731-4735 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions

Liang, H., Yoo, S. E., Na, R., Walter, C. A., Richardson, A. & Ran, Q., Nov 6 2009, In : Journal of Biological Chemistry. 284, 45, p. 30836-30844 9 p.

Research output: Contribution to journalArticle

65 Scopus citations
2008

Base excision repair, aging and health span

Xu, G., Herzig, M., Rotrekl, V. & Walter, C. A., Jul 1 2008, In : Mechanisms of Ageing and Development. 129, 7-8, p. 366-382 17 p.

Research output: Contribution to journalArticle

73 Scopus citations

Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice

Allen, D., Herbert, D. C., McMahan, C. A., Rotrek, V., Sobol, R. W., Wilson, S. H. & Walter, C. A., Nov 1 2008, In : Biology of reproduction. 79, 5, p. 824-831 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis

Xu, G., Intano, G. W., McCarrey, J. R., Walter, R. B., Alex McMahan, C. & Walter, C. A., Jul 31 2008, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 654, 2, p. 150-157 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2007

A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1

Garza, R., Hudson, R. A., McMahan, C. A., Walter, C. A. & Vogel, K. S., Feb 3 2007, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 615, 1-2, p. 98-110 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Assisted reproductive technologies do not alter mutation frequency or spectrum

Caperton, L., Murphey, P., Yamazaki, Y., McMahan, C. A., Walter, C. A., Yanagimachi, R. & McCarrey, J. R., Mar 20 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 12, p. 5085-5090 6 p.

Research output: Contribution to journalArticle

31 Scopus citations
2005

Nucleotide excision repair activity varies among murine spermatogenic cell types

Xu, G., Spivak, G., Mitchell, D. L., Mori, T., McCarrey, J. R., McMahan, C. A., Walter, R. B., Hanawalt, P. C. & Walter, C. A., Jul 1 2005, In : Biology of reproduction. 73, 1, p. 123-130 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Rat synapsin 1 promoter mediated transgene expression in testicular cell types

Street, K. A., Xu, G., Hall, K. L., Intano, G. W., McCarrey, J. R., Herbert, D. C., Kilimann, M. W. & Walter, C. A., Feb 1 2005, In : DNA and Cell Biology. 24, 2, p. 133-140 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2004

Mutation spectral changes in spermatogenic cells obtained from old mice

Walter, C. A., Intano, G. W., McMahan, C. A., Kelner, K., McCarrey, J. R. & Walter, R. B., May 4 2004, In : DNA Repair. 3, 5, p. 495-504 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Spontaneous mutagenesis is enhanced in Apex heterozygous mice

Huamani, J., McMahan, C. A., Herbert, D. C., Reddick, R., McCarrey, J. R., MacInnes, M. I., Chen, D. J. & Walter, C. A., Sep 1 2004, In : Molecular and cellular biology. 24, 18, p. 8145-8153 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis

Ran, Q., Liang, H., Gu, M., Qi, W., Walter, C. A., Roberts, L. J., Herman, B., Richardson, A. & Van Remmen, H., Dec 31 2004, In : Journal of Biological Chemistry. 279, 53, p. 55137-55146 10 p.

Research output: Contribution to journalArticle

161 Scopus citations
2003

Age-related base excision repair activity in mouse brain and liver nuclear extracts

Intano, G. W., Cho, E. J., McMahan, C. A. & Walter, C. A., Mar 1 2003, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 58, 3, p. 205-211 7 p.

Research output: Contribution to journalArticle

Open Access
68 Scopus citations

Germline genomes--a biological fountain of youth?

Walter, C. A., Walter, R. B. & McCarrey, J. R., Feb 26 2003, In : Science of aging knowledge environment : SAGE KE. 2003, 8, p. PE4

Research output: Contribution to journalReview article

17 Scopus citations
2002

Absence of global genomic cytosine methylation pattern erasure during medaka (Oryzias latipes) early embryo development

Walter, R. B., Li, H. Y., Intano, G. W., Kazianis, S. & Walter, C. A., Dec 1 2002, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 133, 4, p. 597-607 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Base excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old mice

Intano, G. W., McMahan, C. A., McCarrey, J. R., Walter, R. B., McKenna, A. E., Matsumoto, Y., MacInnes, M. A., Chen, D. J. & Walter, C. A., Mar 25 2002, In : Molecular and cellular biology. 22, 7, p. 2410-2418 9 p.

Research output: Contribution to journalArticle

49 Scopus citations
2001

Characterization of O6-methylguanine-DNA-methyltransferase (O6-MGMT) activity in Xiphophorus fishes

Walter, R. B., Sung, H. M., Intano, G. W. & Walter, C. A., Jun 27 2001, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 493, 1-2, p. 11-22 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Does oxidative damage to DNA increase with age?

Hamilton, M. L., Van Remmen, H., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A. & Richardson, A., Aug 28 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 18, p. 10469-10474 6 p.

Research output: Contribution to journalArticle

562 Scopus citations

Health span and life span in transgenic mice with modulated DNA repair

Walter, C. A., Zhou, Z. Q., Manguino, D., Ikeno, Y., Reddick, R., Nelson, J., Intano, G., Herbert, D. C., Alex McMahan, C. & Hanes, M., Jan 1 2001, In : Annals of the New York Academy of Sciences. 928, p. 132-140 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mixed spermatogenic germ cell nuclear extracts exhibit high base excision repair activity

Intano, G. W., McMahan, C. A., Walter, R. B., McCarrey, J. R. & Walter, C. A., Mar 15 2001, In : Nucleic acids research. 29, 6, p. 1366-1372 7 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6methylguanine-DNA methyltransferase

Zhou, Z. Q., Manguino, D., Kewitt, K., Intano, G. W., McMahan, C. A., Herbert, D. C., Hanes, M., Reddick, R., Ikeno, Y. & Walter, C. A., Oct 23 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 22, p. 12566-12571 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
2000

Pulmonary expression of the human haptoglobin gene

Yang, F., Ghio, A. J., Herbert, D. C., Weaker, F. J., Walter, C. A. & Coalson, J. J., Jan 1 2000, In : American journal of respiratory cell and molecular biology. 23, 3, p. 277-282 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Using MT(-/-) mice to study metallothionein and oxidative stress

Conrad, C. C., Grabowski, D. T., Walter, C. A., Sabia, M. & Richardson, A., Feb 1 2000, In : Free Radical Biology and Medicine. 28, 3, p. 447-462 16 p.

Research output: Contribution to journalArticle

41 Scopus citations
1999
Open Access
16 Scopus citations

Formamidopyrimidine-DNA glycosylase targeted to specific organelles in C2C12 cells

Street, K. A., Hall, K. L., Murphy, P. & Walter, C. A., 1999, In : Journal of anti-aging medicine. 2, 3, p. 275-285 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Multiple elements influence transcriptional regulation from the human testis-specific PGK2 promoter in transgenic mice

Zhang, L. P., Stroud, J., Eddy, C. A., Walter, C. A. & McCarrey, J. R., Jun 2 1999, In : Biology of reproduction. 60, 6, p. 1329-1337 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
1998

A gene-specific promoter in transgenic mice directs testis-specific demethylation prior to transcriptional activation in vivo

Zhang, L. P., Stroud, J. C., Walter, C. A., Adrian, G. S. & McCarrey, J. R., Aug 1 1998, In : Biology of reproduction. 59, 2, p. 284-292 9 p.

Research output: Contribution to journalArticle

29 Scopus citations