Alexander Pertsemlidis

  • 7973 Citations
  • 29 h-Index
19962020

Research output per year

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Research Output

  • 7973 Citations
  • 29 h-Index
  • 50 Article
  • 6 Review article
  • 3 Comment/debate
  • 1 Short survey
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Article
2020

GD2-directed CAR-T cells in combination with HGF-targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing sarcoma

Charan, M., Dravid, P., Cam, M., Audino, A., Gross, A. C., Arnold, M. A., Roberts, R. D., Cripe, T. P., Pertsemlidis, A., Houghton, P. J. & Cam, H., Jun 1 2020, In : International Journal of Cancer. 146, 11, p. 3184-3195 12 p.

Research output: Contribution to journalArticle

2019

The miR-195 Axis Regulates Chemoresistance through TUBB and Lung Cancer Progression through BIRC5

Yu, X., Zhang, Y., Wu, B., Kurie, J. M. & Pertsemlidis, A., Sep 27 2019, In : Molecular Therapy - Oncolytics. 14, p. 288-298 11 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer

Du, L., Zhao, Z., Suraokar, M., Shelton, S. S., Ma, X., Hsiao, T. H., Minna, J. D., Wistuba, I. & Pertsemlidis, A., Jul 1 2018, In : Oncotarget. 9, 51, p. 29601-29618 18 p.

Research output: Contribution to journalArticle

2 Scopus citations

MicroRNA-2110 functions as an onco-suppressor in neuroblastoma by directly targeting Tsukushi

Zhao, Z., Partridge, V., Sousares, M., Shelton, S. D., Holland, C. L., Pertsemlidis, A. & Du, L., Dec 2018, In : PloS one. 13, 12, e0208777.

Research output: Contribution to journalArticle

3 Scopus citations

miR-195 potentiates the efficacy of microtubule-targeting agents in non-small cell lung cancer

Yu, X., Zhang, Y., Ma, X. & Pertsemlidis, A., Jul 28 2018, In : Cancer Letters. 427, p. 85-93 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

MIR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer

Yu, X., Zhang, Y., Cavazos, D., Ma, X., Zhao, Z., Du, L. & Pertsemlidis, A., Feb 1 2018, In : Cell Death and Disease. 9, 2, 193.

Research output: Contribution to journalArticle

27 Scopus citations
2017

A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling

Lin, J., Zandi, R., Shao, R., Gu, J., Ye, Y., Wang, J., Zhao, Y., Pertsemlidis, A., Wistuba, I. I., Wu, X., Roth, J. A. & Ji, L., Dec 1 2017, In : Scientific reports. 7, 1, 9029.

Research output: Contribution to journalArticle

4 Scopus citations
2016

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

Henry, S., Kidner, R., Reisenauer, M. R., Magedov, I. V., Kiss, R., Mathieu, V., Lefranc, F., Dasari, R., Evidente, A., Yu, X., Ma, X., Pertsemlidis, A., Cencic, R., Pelletier, J., Cavazos, D. A., Brenner, A. J., Aksenov, A. V., Rogelj, S., Kornienko, A. & Frolova, L. V., Sep 14 2016, In : European Journal of Medicinal Chemistry. 120, p. 313-328 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells

Zhao, Z., Ma, X., Shelton, S. D., Sung, D. C., Li, M., Hernandez, D., Zhang, M., Losiewicz, M. D., Chen, Y., Pertsemlidis, A., Yu, X., Liu, Y. & Du, L., Jan 1 2016, In : Oncotarget. 7, 48, p. 79372-79387 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease

Liu, L., Pertsemlidis, A., Ding, L. H., Story, M. D., Steinberg, M. H., Sebastiani, P., Hoppe, C., Ballas, S. K. & Pace, B. S., 2016, In : Experimental Biology and Medicine. 241, 7, p. 706-718 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Genetic mutation of p53 and suppression of the mir-17∼92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin d signaling

Borkowski, R., Du, L., Zhao, Z., McMillan, E., Kosti, A., Yang, C. R., Suraokar, M., Wistuba, I. I., Gazdar, A. F., Minna, J. D., White, M. A. & Pertsemlidis, A., Feb 15 2015, In : Cancer Research. 75, 4, p. 666-675 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer

Masi, M., Frolova, L. V., Yu, X., Mathieu, V., Cimmino, A., De Carvalho, A., Kiss, R., Rogelj, S., Pertsemlidis, A., Kornienko, A. & Evidente, A., Apr 2015, In : Fitoterapia. 102, p. 41-48 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest

Zhao, Z., Ma, X., Sung, D., Li, M., Kosti, A., Lin, G., Chen, Y., Pertsemlidis, A., Hsiao, T. H. & Du, L., 2015, In : RNA Biology. 12, 5, p. 538-554 17 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

A high-content morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation

Zhao, Z., Ma, X., Hsiao, T. H., Lin, G., Kosti, A., Yu, X., Suresh, U., Chen, Y., Tomlinson, G. E., Pertsemlidis, A. & Du, L., 2014, In : Oncotarget. 5, 9, p. 2499-2512 14 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Genome-wide association analysis of radiation resistance in Drosophila melanogaster

Vaisnav, M., Xing, C., Ku, H. C., Hwang, D., Stojadinovic, S., Pertsemlidis, A. & Abrams, J. M., Aug 14 2014, In : PloS one. 9, 8, e104858.

Research output: Contribution to journalArticle

15 Scopus citations

MiR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer

Du, L., Zhao, Z., Ma, X., Hsiao, T. H., Chen, Y., Young, E., Suraokar, M., Wistuba, I., Minna, J. D. & Pertsemlidis, A., Aug 21 2014, In : Oncogene. 33, 34, p. 4307-4315 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
2013

A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel

Du, L., Borkowski, R., Zhao, Z., Ma, X., Yu, X., Xie, X. J. & Pertsemlidis, A., Nov 1 2013, In : RNA biology. 10, 11, p. 1700-1713 14 p.

Research output: Contribution to journalArticle

25 Scopus citations
2012

Genomic Loss of Tumor Suppressor miRNA-204 Promotes Cancer Cell Migration and Invasion by Activating AKT/mTOR/Rac1 Signaling and Actin Reorganization

Imam, J. S., Plyler, J. R., Bansal, H., Prajapati, S., Bansal, S., Rebeles, J., Chen, H. I. H., Chang, Y. F., Panneerdoss, S., Zoghi, B., Buddavarapu, K. C., Broaddus, R., Hornsby, P., Tomlinson, G., Dome, J., Vadlamudi, R. K., Pertsemlidis, A., Chen, Y. & Rao, M. K., Dec 21 2012, In : PloS one. 7, 12, e52397.

Research output: Contribution to journalArticle

98 Scopus citations

miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers

Du, L., Subauste, M. C., DeSevo, C., Zhao, Z., Baker, M., Borkowski, R., Schageman, J. J., Greer, R., Yang, C. R., Suraokar, M., Wistuba, I. I., Gazdar, A. F., Minna, J. D. & Pertsemlidis, A., Jun 18 2012, In : PloS one. 7, 6, e39167.

Research output: Contribution to journalArticle

73 Scopus citations

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression

Ahn, Y. H., Gibbons, D. L., Chakravarti, D., Creighton, C. J., Rizvi, Z. H., Adams, H. P., Pertsemlidis, A., Gregory, P. A., Wright, J. A., Goodall, G. J., Flores, E. R. & Kurie, J. M., Sep 4 2012, In : Journal of Clinical Investigation. 122, 9, p. 3170-3183 14 p.

Research output: Contribution to journalArticle

91 Scopus citations
2011

Minimum Information about a Genotyping Experiment (MIGEN)

Huang, J., Mirel, D., Pugh, E., Xing, C., Robinson, P. N., Pertsemlidis, A., Ding, L. H., Kozlitina, J., Maher, J., Rios, J., Story, M., Marthandan, N. & Scheuermann, R. H., Dec 15 2011, In : Standards in Genomic Sciences. 5, 2, p. 224-229 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2010

Diverse Pathways Generate MicroRNA-like RNAs and Dicer-Independent Small Interfering RNAs in Fungi

Lee, H. C., Li, L., Gu, W., Xue, Z., Crosthwaite, S. K., Pertsemlidis, A., Lewis, Z. A., Freitag, M., Selker, E. U., Mello, C. C. & Liu, Y., Jun 1 2010, In : Molecular Cell. 38, 6, p. 803-814 12 p.

Research output: Contribution to journalArticle

201 Scopus citations

MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs

Du, L., Schageman, J. J., Irnov, Girard, L., Hammond, S. M., Minna, J. D., Gazdar, A. F. & Pertsemlidis, A., Aug 2 2010, In : Journal of Experimental and Clinical Cancer Research. 29, 1, 75.

Research output: Contribution to journalArticle

55 Scopus citations

Power of Genetic Association Studies with Fixed and Random Genotype Frequencies

Kozlitina, J., Xing, C., Pertsemlidis, A. & Schucany, W. R., Sep 1 2010, In : Annals of Human Genetics. 74, 5, p. 429-438 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2009

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

Gibbons, D. L., Lin, W., Creighton, C. J., Rizvi, Z. H., Gregory, P. A., Goodall, G. J., Thilaganathan, N., Du, L., Zhang, Y., Pertsemlidis, A. & Kurie, J. M., Sep 15 2009, In : Genes and Development. 23, 18, p. 2140-2151 12 p.

Research output: Contribution to journalArticle

332 Scopus citations

microRNAs mature with help from cancer biology.

Paroo, Z. & Pertsemlidis, A., 2009, In : Genome biology. 10, 7, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1

Du, L., Schageman, J. J., Subauste, M. C., Saber, B., Hammond, S. M., Prudkin, L., Wistuba, I. I., Ji, L., Roth, J. A., Minna, J. D. & Pertsemlidis, A., Aug 1 2009, In : Molecular Cancer Research. 7, 8, p. 1234-1243 10 p.

Research output: Contribution to journalArticle

181 Scopus citations

Predicting potential miRNA target sites within gene promoters

Younger, S. T., Pertsemlidis, A. & Corey, D. R., Jul 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 14, p. 3791-3794 4 p.

Research output: Contribution to journalArticle

46 Scopus citations
2008

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C. & Hobbs, H. H., Dec 1 2008, In : Nature Genetics. 40, 12, p. 1461-1465 5 p.

Research output: Contribution to journalArticle

1532 Scopus citations
2007

A common allele on chromosome 9 associated with coronary heart disease

McPherson, R., Pertsemlidis, A., Kavaslar, N., Stewart, A., Roberts, R., Cox, D. R., Hinds, D. A., Pennacchio, L. A., Tybjaerg-Hansen, A., Folsom, A. R., Boerwinkle, E., Hobbs, H. H. & Cohen, J. C., Jun 8 2007, In : Science. 316, 5830, p. 1488-1491 4 p.

Research output: Contribution to journalArticle

1301 Scopus citations

Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol

Spirin, V., Schmidt, S., Pertsemlidis, A., Cooper, R. S., Cohen, J. C. & Sunyaev, S. R., Jan 1 2007, In : American Journal of Human Genetics. 81, 6, p. 1298-1303 6 p.

Research output: Contribution to journalArticle

29 Scopus citations
2006

A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol

Kotowski, I. K., Pertsemlidis, A., Luke, A., Cooper, R. S., Vega, G. L., Cohen, J. C. & Hobbs, H. H., Mar 2006, In : American Journal of Human Genetics. 78, 3, p. 410-422 13 p.

Research output: Contribution to journalArticle

396 Scopus citations

Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels

Cohen, J. C., Pertsemlidis, A., Fahmi, S., Esmail, S., Vega, G. L., Grundy, S. M. & Hobbs, H. H., Feb 15 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 6, p. 1810-1815 6 p.

Research output: Contribution to journalArticle

304 Scopus citations
2005

Analysis of the regulation of lin-41 during chick and mouse limb development

Lancman, J. J., Caruccio, N. C., Harfe, B. D., Pasquinelli, A. E., Schageman, J. J., Pertsemlidis, A. & Fallon, J. F., Dec 1 2005, In : Developmental Dynamics. 234, 4, p. 948-960 13 p.

Research output: Contribution to journalArticle

45 Scopus citations

Bayesian statistical studies of the Ramachandran distribution

Pertsemlidis, A., Zelinka, J., Fondon, J. W., Henderson, R. K. & Otwinowski, Z., Nov 22 2005, In : Statistical Applications in Genetics and Molecular Biology. 4, 1, p. i-16 35.

Research output: Contribution to journalArticle

14 Scopus citations

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Cohen, J., Pertsemlidis, A., Kotowski, I. K., Graham, R., Garcia, C. K. & Hobbs, H. H., Feb 1 2005, In : Nature Genetics. 37, 2, p. 161-165 5 p.

Research output: Contribution to journalArticle

857 Scopus citations

Selective identification of secreted and transmembrane breast cancer markers using Escherichia coli ampicillin secretion trap

Ferguson, D. A., Muenster, M. R., Zang, Q., Spencer, J. A., Schageman, J. J., Lian, Y., Garner, H. R., Gaynor, R. B., Huff, J. W., Pertsemlidis, A., Ashfaq, R., Schorge, J., Becerra, C., Williams, N. S. & Graff, J. M., Sep 15 2005, In : Cancer Research. 65, 18, p. 8209-8217 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2004

Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus

Wandstrat, A. E., Nguyen, C., Limaye, N., Chan, A. Y., Subramanian, S., Tian, X. H., Yim, Y. S., Pertsemlidis, A., Garner, H. R., Morel, L. & Wakeland, E. K., Dec 1 2004, In : Immunity. 21, 6, p. 769-780 12 p.

Research output: Contribution to journalArticle

213 Scopus citations

ELXR: a resource for rapid exon-directed sequence analysis.

Schageman, J. J., Horton, C. J., Niu, S., Garner, H. R. & Pertsemlidis, A., 2004, In : Genome biology. 5, 5, p. R36

Research output: Contribution to journalArticle

14 Scopus citations

Multiple rare alleles contribute to low plasma levels of HDL cholesterol

Cohen, J. C., Kiss, R. S., Pertsemlidis, A., Marcel, Y. L., McPherson, R. & Hobbs, H. H., Aug 6 2004, In : Science. 305, 5685, p. 869-872 4 p.

Research output: Contribution to journalArticle

856 Scopus citations
2003

SNPCEQer II: the integrated detection and analysis of SNPs in DNA sequences.

Tang, F., Flood, E. M., Pertsemlidis, A. & Garner, H. R., 2003, In : Applied bioinformatics. 2, 3, p. 151-154 4 p.

Research output: Contribution to journalArticle

2002

Arrogant: An application to manipulate large gene collections

Kulkarni, A. V., Williams, N. S., Lian, Y., Wren, J. D., Mittelman, D., Pertsemlidis, A. & Garner, H. R., Nov 1 2002, In : Bioinformatics. 18, 11, p. 1410-1417 8 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

SNPCEQer: Detecting SNPs in sequences generated by the Beckman CEQ™2000 DNA Analysis System

Flood, E. M., Tang, F., Horvath, M. M., Pertsemlidis, A. & Garner, H. R., Oct 1 2002, In : BioTechniques. 33, 4, p. 814-822 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2000

Panorama: An integrated web-based sequence analysis tool and its role in gene discovery

Pertsemlidis, A., Pande, A., Miller, B., Schilling, P., Wei, M. H., Lerman, M. I., Minna, J. D. & Garner, H. R., Dec 15 2000, In : Genomics. 70, 3, p. 300-306 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Repeat polymorphisms within gene regions: Phenotypic and evolutionary implications

Wren, J. D., Forgacs, E., Fondon, J. W., Pertsemlidis, A., Cheng, S. Y., Gallardo, T., Williams, R. S., Shohet, R. V., Minna, J. D. & Garner, H. R., Jan 1 2000, In : American Journal of Human Genetics. 67, 2, p. 345-356 12 p., 62646.

Research output: Contribution to journalArticle

111 Scopus citations

The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes

Lerman, M. I., Minna, J. D., Sekido, Y., Bader, S., Burbee, D., Fong, K., Forgacs, E., Gao, B., Garner, H., Gazdar, A. F., Girard, L., Kamibayashi, C., Kondo, M., Pande, A., Persemlidis, A., Ramalingam, V., Randle, D., Tomizawa, Y., Virmani, A., Wistuba, I. & 19 others, Zeng, G., Macartney, D., Honorio, S., Maher, E., Latif, F., Kashuba, V., Protopopov, A., Li, J., Klein, G., Zabarovsky, E., Duh, F. M., Wei, M. H., Geil, L., Kuzmin, I., Ivanov, S., Angeloni, D., Ivanova, A., Zbar, B. & Johnson, B. E., Nov 1 2000, In : Cancer Research. 60, 21, p. 6116-6133 18 p.

Research output: Contribution to journalArticle

500 Scopus citations
1999

Determining the role of hydration forces in protein folding

Sorenson, J. M., Hura, G., Soper, A. K., Pertsemlidis, A. & Head-Gordon, T., Jul 1 1999, In : Journal of Physical Chemistry B. 103, 26, p. 5424-5426 3 p.

Research output: Contribution to journalArticle

78 Scopus citations

Evidence for microscopic, long-range hydration forces for a hydrophobic amino acid

Pertsemlidis, A., Soper, A. K., Sorenson, J. M. & Head-Gordon, T., Jan 19 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 2, p. 481-486 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
1997

Differences in hydration structure near hydrophobic and hydrophilic amino acids

Head-Gordon, T., Sorenson, J. M., Pertsemlidis, A. & Glaeser, R. M., Oct 1997, In : Biophysical Journal. 73, 4, p. 2106-2115 10 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations
1996

Direct evidence for modified solvent structure within the hydration shell of a hydrophobic amino acid

Pertsemlidis, A., Saxena, A. M., Soper, A. K., Head-Gordon, T. & Glaeser, R. M., Oct 1 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 20, p. 10769-10774 6 p.

Research output: Contribution to journalArticle

73 Scopus citations