Organization profile

Organization profile

Imagine living with strength and vitality throughout your life span, growing older with vigor and without disability. The Sam and Ann Barshop Institute for Longevity and Aging Studies brings together the world’s leading scientists in aging and longevity research, and providing them with the latest technologies in the application of cutting-edge research methods, supports their drive for excellence in scientific inquiry, an essential element to bringing good health and enhanced quality of life to our aging population.

Aging affects everyone. Never before in the history of humankind has understanding how and why we age been so important. As human life expectancy continues to increase, so must our scientific knowledge of aging processes to ensure healthy longevity, free of the disabilities brought about by age-related diseases and conditions.

The Barshop Institute supports research on age-related diseases and longevity. The Institute is designated as a Nathan Shock Center and the Claude D. Pepper Center and supports translational research with the goal of improving health throughout life. The Institute is also actively involved in community outreach programs to educate health care professionals on health issues facing the aging population.

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Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

pioglitazone Medicine & Life Sciences
Insulin Resistance Medicine & Life Sciences
Insulin Medicine & Life Sciences
Glucose Medicine & Life Sciences
Type 2 Diabetes Mellitus Medicine & Life Sciences
AMP-Activated Protein Kinases Medicine & Life Sciences
Muscles Medicine & Life Sciences
Glucose Intolerance Medicine & Life Sciences

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Projects 2007 2018

Effect of age on glucose and lipid metabolism

Musi, N.

National Institutes of Health

9/10/108/31/15

Project: Research projectResearch Project

AMP-Activated Protein Kinases
Lipid Metabolism
Glucose
Insulin Resistance
Muscles

Role of TLR4 on insulin resistance in human muscle

Musi, N.

National Institutes of Health

1/1/087/31/18

Project: Research projectResearch Project

Insulin Resistance
Muscles
Type 2 Diabetes Mellitus
Insulin
Skeletal Muscle

Role of IKK/lkB/NFkB Signaling in Insulin Resistance in Aging Muscle

Musi, N.

National Institutes of Health

9/1/075/31/11

Project: Research projectMentored Patient-Oriented Research Career Development Award

Insulin Resistance
Muscles
Insulin
Reactive Oxygen Species
Lipids

Research Output 2006 2018

2 Citations

A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects

Kraig, E. B., Linehan, L. A., Liang, H., Romo, T. Q., Liu, Q., Wu, Y., Benavides, A. D., Curiel, T. J., Javors, M. A., Musi, N., Chiodo, L., Koek, W., Gelfond, J. A. & Kellogg Jr, D. L., Jan 1 2018, (Accepted/In press) In : Experimental Gerontology.

Research output: Contribution to journalArticle

Sirolimus
Safety
Therapeutics
Erythrocyte Indices
Clinical laboratories
2 Citations

DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease

Chen, H., Shen, F., Sherban, A., Nocon, A., Li, Y., Wang, H., Xu, M. J., Rui, X., Han, J., Jiang, B., Lee, D., Li, N., Keyhani-Nejad, F., Fan, J. G., Liu, F., Kamat, A., Musi, N., Guarente, L., Pacher, P., Gao, B. & 1 othersZang, M., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

TOR Serine-Threonine Kinases
Alcoholic Liver Diseases
Lipogenesis
Sirtuin 1
Liver

Older subjects with β -cell dysfunction have an accentuated incretin release

De Jesús Garduno-Garcia, J., Gastaldelli, A., Defronzo, R. A., Lertwattanarak, R., Holst, J. J. & Musi, N., Jul 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 7, p. 2613-2619 7 p.

Research output: Contribution to journalArticle

Incretins
Glucose Intolerance
Glucagon-Like Peptide 1
Gastric Inhibitory Polypeptide
Glucose