Microbiology, Immunology &amp; Molecular Genetics

6/15/15 → 5/31/17

Project: Research project

Candida tropicalis

Candida

Virulence

Candida albicans

Aptitude

Pan-Fungal Essential Gene Discovery for Antifungal Targeting

Wickes, B. L.

5/1/15 → 4/30/17

Project: Research project

Fungal Genes

Essential Genes

Genetic Association Studies

Agrobacterium tumefaciens

Pharmaceutical Preparations

Cardiac microlesion formation during invasive pneumococcal disease

Orihuela, C. J.

11/1/14 → 10/31/19

Project: Research project

Streptococcus pneumoniae

Biofilms

Cardiac Myocytes

Cytokines

Chemokines

A novel role for the TLR signaling adaptor TRAM

8/24/12 → 10/31/14

Project: Research project

Toll-Like Receptors

Francisella tularensis

Listeriosis

Listeria monocytogenes

Tularemia

Transcriptional Regulation by a Deacetylase, CobB, in a Periodontopathogen

4/1/12 → 2/28/15

Project: Research project

Aggregatibacter actinomycetemcomitans

Lysine

Acetylation

Transcription Factors

Bacteria

Statins protect against adverse cardiac events during pneumonia

Orihuela, C. J.

4/1/11 → 12/31/13

Project: Research project

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Pneumonia

Cardiac Myocytes

Cell Wall

Platelet Activating Factor

Determination of morphology and virulence in Candida albicans

Kadosh, D.

5/15/10 → 4/30/16

Project: Research project

Candida albicans

Virulence

Yeasts

Infection

Cues

Control of Candida albicans Filamentous Growth and Virulence

Kadosh, D.

9/30/09 → 8/31/11

Project: Research project

Candida albicans

Virulence

Growth

Cues

Aptitude

Age-associated Toll-like receptor dysfunction in the lungs

Orihuela, C. J.

4/1/09 → 3/31/12

Project: Research project

Toll-Like Receptors

Lung

Pneumonia

Alveolar Macrophages

Toll-Like Receptor 1

Mechanism of PsrP mediated adhesion

Orihuela, C. J.

1/23/09 → 12/31/14

Project: Research project

Operon

Oxygen

Biofilms

Vaccination

Virulence

Immune modulation mechanism mediated by poxvirus IL-18 binding protein

Xiang, Y.

9/24/08 → 3/31/19

Project: Research project

Poxviridae

Interleukin-18

Immune Evasion

Vaccines

Monkeypox virus

Age-associated inflammation increases susceptibility to pneumococcal infection

Orihuela, C. J.

9/30/07 → 8/31/10

Project: Research project

Pneumococcal Infections

Polymeric Immunoglobulin Receptors

Streptococcus pneumoniae

Inflammation

Lung

Molecular Mechanism of Poxvirus Host Range Genes

Xiang, Y.

9/20/07 → 8/31/10

Project: Research project

Poxviridae

Host Specificity

Ankyrin Repeat

Mitogen-Activated Protein Kinase 7

Orthopoxvirus

Host response to Yersinia pestis infection

Dube, P. H.

9/20/07 → 8/31/10

Project: Research project

Yersinia Infections

Yersinia pestis

Plague

Tissue Array Analysis

Cytokines

Role of IL-6 in the Pathogenesis of Yersinia enterocolitica infection

Dube, P. H.

6/1/07 → 5/31/13

Project: Research project

Yersinia Infections

Yersinia enterocolitica

Interleukin-6

Cytokines

Infection

Novel Mycoplasma pneumoniae CARDS Toxin as Mediator of Airway Dysfuntion in Mice

Dube, P. H., Coalson, J. J., Peters, J. I., Hart, P. J., Baseman, J. B., Hardy, R. D. & Cagle, M. P.

7/1/06 → 7/31/16

Project: Research project

Mycoplasma pneumoniae

Asthma

Adenosine Diphosphate

Mycoplasma

Pathology

T cell loss in a murine model for AIDS

Scofield, V.

9/30/05 → 2/29/08

Project: Research project

Murine Acquired Immunodeficiency Syndrome

Thymocytes

T-Lymphocytes

Thymus Gland

Atrophy

Chlamydia trachomatis proteomics

4/1/05 → 12/31/16

Project: Research project

Chlamydia trachomatis

Proteomics

proteomics

Subunit Vaccines

genome

Characterization of F. tularensis Virulence Genes

Berton, M. T., Arulanandam, B. P., Teale, J., Wickes, B. & Klose, K.

4/1/05 → 6/30/12

Project: Research project

Tularemia

Francisella tularensis

Toll-Like Receptors

Immunity

Lung

Anaerobic Regulatory Pathways in a Periodontopathogen

7/1/04 → 3/31/10

Project: Research project

Aggregatibacter actinomycetemcomitans

Proteins

Oxygen

Virulence

Genes

Chlamydial Manipulation of Host Apoptosis

7/1/04 → 9/30/12

Project: Research project

Chlamydia

Apoptosis

Infection

Pathology

Pneumonia

Poxvirus immune modulators and the host Immune system

Xiang, Y.

4/1/03 → 3/31/06

Project: Research project

Poxviridae

Interleukin-18

Immune System

Molluscum contagiosum virus

Interleukin-18 Receptors

Congenic strains of serotype A Cryptococcus neoformans

Wickes, B. L.

2/1/03 → 1/31/07

Project: Research project

Cryptococcus neoformans

Virulence

Infection

Acquired Immunodeficiency Syndrome

Serogroup

Role of Nitirc Oxide in Experimental Myasthenia Gravis

2/1/03 → 1/31/09

Project: Research project

Autoimmune Experimental Myasthenia Gravis

Cholinergic Receptors

Oxides

Nitric Oxide

Inbred WF Rats

Cooperative Mechanisms in IL-4-Induced Gene Expression

12/1/02 → 11/30/08

Project: Research project

Interleukin-4

Gene Expression

Serine

Phosphorylation

Janus Kinases

Fluorescence, Chemiluminescence and Phosphor Imager

3/1/02 → 2/28/03

Project: Research project

Luminescence

Fluorescence

Cyclonic Storms

Research

Immunoglobulin Class Switching

Role of IL-1 in Yersinia Induced Intestinal Inflammation

Dube, P. H.

9/1/01 → 5/31/03

Project: Research project

Yersinia

Interleukin-1

Yersinia Infections

Inflammation

Integration Host Factors

Exacerbation of Atherosclerosis

7/1/01 → 6/30/06

Project: Research project

Atherosclerosis

Pneumonia

Infection

Cerebral Infarction

Lipoproteins

MECHANISMS OF CHLAMYDIAL EVASION OF IMMUNE RECOGNATION

7/15/00 → 11/30/16

Project: Research project

Immune Evasion

Chlamydia

Proteasome Endopeptidase Complex

Peptide Hydrolases

Infection

MYCOPLASMA PNEUMONIAE - AIRWAY INTERPLAY

Baseman, J. B.

4/1/00 → 3/31/07

Project: Research project

Mycoplasma pneumoniae

Mycoplasma

Fibronectins

Respiratory System

Pulmonary Surfactant-Associated Protein A

SECRETION MECHANISM OF A NOVEL C. RECTUS S-LAYER PROTEIN

4/1/00 → 3/31/04

Project: Research project

Campylobacter rectus

Operon

Genes

Proteins

Mutagenesis

SAN ANTONIO SEXUALLY TRANSMITTED DISEASES COOPERATIVE RE

Baseman, J. B., Piper, J., Jenson, H., Zhong, G., Alderete, J., Perdue, S. & Shain, R.

9/30/99 → 8/31/12

Project: Research project

Sexually Transmitted Diseases

Mycoplasma genitalium

Mycoplasma Infections

Trichomonas vaginalis

Mycoplasma

MYOCYTE RESPONSES DURING EXPERIMENTAL MYASTHENIA GRAVIS

7/1/99 → 6/30/03

Project: Research project

Autoimmune Experimental Myasthenia Gravis

Cholinergic Receptors

Muscle Cells

Myasthenia Gravis

Antibodies

MATING TYPE AND VIRULENCE IN CRYPTOCOCCUS NEOFORMANS

Wickes, B. L.

6/1/98 → 5/31/04

Project: Research project

Cryptococcus neoformans

virulence

fruiting

genes

phenotype

DETERMINANTS OF DISEASE IN EXPERIMENTAL MYASTHENIA GRAVI

5/1/97 → 4/30/02

Project: Research project

Autoimmune Experimental Myasthenia Gravis

Cholinergic Receptors

Antibodies

Inbred WF Rats

Myasthenia Gravis

MECHANISMS OF MYCOPLASMA CYTADHERENCE AND INVASION

Baseman, J. B.

7/1/96 → 1/31/09

Project: Research project

Mycoplasma

Mycoplasma genitalium

Virulence

Tenericutes

Pneumonia

CONTROL OF SWITCH RECOMBINATION BY CD40 LIGAND

7/1/96 → 6/30/02

Project: Research project

Immunoglobulin Genes

CD40 Ligand

Immunoglobulin Class Switching

Genetic Recombination

Interleukin-4

ANTIBODIES THAT PLAY DIFFERENT ROLES IN MYASTHENIA GRAVI

12/1/95 → 11/30/99

Project: Research project

Myasthenia Gravis

Anti-Idiotypic Antibodies

Antibodies

Isoelectric Focusing

Peptides

REGULATION OF LEUKOTOXIN IN A ACTINOMYCETEMCOMITANS

9/1/93 → 8/31/02

Project: Research project

Aggregatibacter actinomycetemcomitans

leukotoxins

Virulence Factors

Periodontitis

Aggressive Periodontitis

NEUROMUSCLUAR IMMUNOPATHOLOGY IN EAMG-RESISTANT RATS

5/1/93 → 4/30/98

Project: Research project

Inbred WF Rats

T-Cell Antigen Receptor Specificity

Disease Resistance

Antibodies

Disease Susceptibility

INTERVENTIVE STRATEGIES FOR MYASTHENIA GRAVIS

Infante, A. J., Krolick, K. A., Barohn, R. & Sanz, I.

9/1/92 → 4/30/97

Project: Research project

Myasthenia Gravis

Immunotoxins

T-Lymphocytes

Cholinergic Receptors

T-Cell Antigen Receptor

BIOLOGY OF AIDS-RELATED MYCOPLASMAS

Baseman, J. B.

9/1/92 → 8/31/96

Project: Research project

Mycoplasma

Acquired Immunodeficiency Syndrome

Cell Communication

Genes

Immunodominant Epitopes

MUTATIONAL ANALYSIS OF THE FUNCTIONS OF HMG PROTEINS

5/1/92 → 4/30/97

Project: Research project

proteins

chromatin

in vitro studies

DNA

cells

CHARACTERIZATION OF DISEASE-CAUSING ANTIBODIES IN EAMG

12/1/89 → 11/30/94

Project: Research project

Autoimmune Experimental Myasthenia Gravis

Cholinergic Receptors

Antibodies

Immunotoxins

Ricin

MOLECULAR ANALYSIS OF ADHESIN P1

Baseman, J. B.

9/1/89 → 7/31/95

Project: Research project

Pneumonia

Virulence

Epitopes

Gene Conversion

Respiratory Mucosa

STUDIES OF SPERM-LYMPHOCYTE INTERACTION STRUCTURES

Scofield, V.

9/30/87 → 8/31/92

Project: Research project

Spermatozoa

Lymphocytes

Major Histocompatibility Complex

Urochordata

Blood Cells

NEUROMUSCULAR IMMUNOPATHOLOGY IN EAMG

7/1/87 → 9/29/93

Project: Research project

Cholinergic Receptors

T-Cell Antigen Receptor Specificity

Antibody Formation

T-Lymphocytes

T-cells

MUTATIONAL ANALYSIS OF THE BIOLOGICAL FUNCTION OF HMG PR

12/1/84 → 5/31/88

Project: Research project

High Mobility Group Proteins

Yeasts

Chromatin

Genes

Fungal Proteins

MOLECULAR MECHANISMS OF MICROBIAL PATHOGENESIS

Baseman, J. B., Eisenstein, B., Alderete, J. & Zhong, G.