Department of Cellular & Integrative Physiology

2016

A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated

Fischer, K. E., Hoffman, J. M., Sloane, L. B., Gelfond, J. A. L., Soto, V. Y., Richardson, A. G. & Austad, S. N., 2016, In: Aging. 8, 10, p. 2370-2391 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Adaptations to chronic rapamycin in mice

Dodds, S. G., Livi, C. B., Parihar, M., Hsu, H. K., Benavides, A. D., Morris, J., Javors, M., Strong, R., Christy, B., Hasty, P. & Sharp, Z. D., May 27 2016, In: Pathobiology of Aging and Age-related Diseases. 6, 31688.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Alkaline activation of ClC-K2 chloride channels switches renal cells from reabsorbing to secreting

Wingo, C. S. & Stockand, J. D., 2016, In: Journal of General Physiology. 148, 3, p. 195-199 5 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

4 Scopus citations

Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury

Calvo, M., Richards, N., Schmid, A. B., Barroso, A., Zhu, L., Ivulic, D., Zhu, N., Anwandter, P., Bhat, M. A., Court, F. A., McMahon, S. B. & Bennett, D. L. H., Apr 19 2016, In: eLife. 5, APRIL2016, e12661.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Biphasic modulation of parallel fibre synaptic transmission by co-activation of presynaptic GABA_A and GABA_B receptors in mice

Howell, R. D. & Pugh, J. R., Jul 1 2016, In: Journal of Physiology. 594, 13, p. 3651-3666 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Bone morphogenetic protein-2 (BMP-2) activates NFATc1 transcription factor via an autoregulatory loop involving Smad/Akt/Ca²⁺ signaling

Mandal, C. C., Das, F., Ganapathy, S., Harris, S. E., Choudhury, G. G. & Ghosh-Choudhury, N., Jan 15 2016, In: Journal of Biological Chemistry. 291, 3, p. 1148-1161 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons

Zhang, J., Carver, C. M., Choveau, F. S. & Shapiro, M. S., Oct 19 2016, In: Neuron. 92, 2, p. 461-478 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

Connexin arrests the cell cycle through cytosolic retention of an E3 ligase

Shi, Q. & Jiang, J. X., Mar 3 2016, In: Molecular and Cellular Oncology. 3, 2, e1132119.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

6 Scopus citations

Critical role of mitochondrial ROS is dependent on their site of production on the electron transport chain in ischemic heart

Madungwe, N. B., Zilberstein, N. F., Feng, Y. & Bopassa, J. C., 2016, In: American Journal of Cardiovascular Disease. 6, 3, p. 93-108 16 p.

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Delayed methylene blue improves lesion volume, multi-parametric quantitative magnetic resonance imaging measurements, and behavioral outcome after traumatic brain injury

Watts, L. T., Long, J. A., Boggs, R. C., Manga, H., Huang, S., Shen, Q. & Duong, T. Q., Jan 15 2016, In: Journal of Neurotrauma. 33, 2, p. 194-202 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Discordance between central (Brain) and pancreatic action of exenatide in lean and obese subjects

Eldor, R., Daniele, G., Huerta, C., Al-Atrash, M., Adams, J., De Fronzo, R., Duong, T., Lancaster, J., Zirie, M., Jayyousi, A. & Abdul-Ghani, M., Oct 1 2016, In: Diabetes care. 39, 10, p. 1804-1810 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development

Mino, R. E., Rogers, S. L., Risinger, A. L., Rohena, C., Banerjee, S. & Bhat, M. A., 2016, In: Journal of cell science. 129, 17, p. 3282-3294 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Effects of stroke severity and treatment duration in normobaric hyperoxia treatment of ischemic stroke

Tiwari, Y. V., Jiang, Z., Sun, Y., Du, F., Rodriguez, P., Shen, Q. & Duong, T. Q., Mar 15 2016, In: Brain Research. 1635, p. 121-129 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Extension of health span and life span in Drosophila by S107 requires the calstabin homologue FK506-BP2

Kreko-Pierce, T., Azpurua, J., Mahoney, R. E. & Eaton, B. A., Dec 9 2016, In: Journal of Biological Chemistry. 291, 50, p. 26045-26055 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity

Brackley, A. D., Gomez, R., Akopian, A. N., Henry, M. A. & Jeske, N. A., Sep 1 2016, In: Cell Reports. 16, 10, p. 2686-2698 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Hydrophobic motif site-phosphorylated protein kinase CβII between mTORC2 and Akt regulates high glucose-induced mesangial cell hypertrophy

Das, F., Ghosh-Choudhury, N., Mariappan, M. M., Kasinath, B. S. & Choudhury, G. G., Apr 1 2016, In: American Journal of Physiology - Cell Physiology. 310, 7, p. C583-C596

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Identification of Caspase-6 as a new regulator of alternatively activated macrophages

Yao, Y., Shi, Q., Chen, B., Wang, Q., Li, X., Li, L., Huang, Y., Ji, J. & Shen, P., Aug 12 2016, In: Journal of Biological Chemistry. 291, 33, p. 17450-17466 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Impact of Hypertension on Cognitive Function: A Scientific Statement from the American Heart Association

Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Quality of Care and Outcomes Research, and Stroke Council, the American Heart Association Council on Hypertension & Council on Clinical Cardiology, Dec 1 2016, In: Hypertension. 68, 6, p. e67-e94

Research output: Contribution to journal › Article › peer-review

Open Access

501 Scopus citations

Induced pluripotent stem cells from nonhuman primates

Mishra, A., Qiu, Z., Farnsworth, S. L., Hemmi, J. J., Li, M., Pickering, A. V. & Hornsby, P. J., Jan 1 2016, Methods in Molecular Biology. Humana Press, p. 183-193 11 p. (Methods in Molecular Biology; vol. 1357).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Open Access

7 Scopus citations

Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery

Mahoney, R. E., Azpurua, J. & Eaton, B. A., Aug 15 2016, In: eLife. 5, AUGUST, e16807.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Intrinsic resting-state functional connectivity in the human spinal cord at 3.0 T

Nateras, O. S. E., Yu, F., Muir, E. R., Bazan, C., Franklin, C. G., Li, W., Li, J., Lancaster, J. L. & Duong, T. Q., Apr 2016, In: Radiology. 279, 1, p. 262-268 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., Fernandez, E., Flurkey, K., Hamilton, K. L., Lamming, D. W., Javors, M. A., de Magalhães, J. P., Martinez, P. A., McCord, J. M., Miller, B. F., Müller, M., Nelson, J. F., Ndukum, J., Rainger, G. E. & Richardson, A. & 6 others, Sabatini, D. M., Salmon, A. B., Simpkins, J. W., Steegenga, W. T., Nadon, N. L. & Harrison, D. E., Oct 1 2016, In: Aging cell. 15, 5, p. 872-884 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

254 Scopus citations

Magnetic resonance imaging in experimental traumatic brain injury

Shen, Q., Watts, L. T., Li, W. & Duong, T. Q., 2016, Methods in Molecular Biology. Humana Press, p. 645-658 14 p. (Methods in Molecular Biology; vol. 1462).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Measures of healthspan as indices of aging in Mice-A recommendation

Richardson, A. G., Fischer, K. E., Speakman, J. R., De Cabo, R., Mitchell, S. J., Peterson, C. A., Rabinovitch, P., Chiao, Y. A., Taffet, G., Miller, R. A., Rentería, R. C., Bower, J., Ingram, D. K., Ladiges, W. C., Ikeno, Y., Sierra, F. & Austad, S. N., Apr 1 2016, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 4, p. 427-430 4 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

68 Scopus citations

Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve

Zhang, J. & Shapiro, M. S., Jan 1 2016, In: Journal of Physiology. 594, 1, p. 31-37 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

MicroRNA-214 reduces insulin-like growth factor-1 (IGF-1) receptor expression and downstream mTORC1 signaling in renal carcinoma cells

Das, F., Dey, N., Bera, A., Kasinath, B. S., Ghosh-Choudhury, N. & Choudhury, G. G., Jul 8 2016, In: Journal of Biological Chemistry. 291, 28, p. 14662-14676 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Mitochondrial metabolites extend lifespan

Mishur, R. J., Khan, M., Munkácsy, E., Sharma, L., Bokov, A., Beam, H., Radetskaya, O., Borror, M., Lane, R., Bai, Y. & Rea, S. L., Apr 1 2016, In: Aging cell. 15, 2, p. 336-348 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Multimodal MRI characterization of experimental subarachnoid hemorrhage

Sun, Y., Shen, Q., Watts, L. T., Muir, E. R., Huang, S., Yang, G. Y., Suarez, J. I. & Duong, T. Q., Mar 1 2016, In: Neuroscience. 316, p. 53-62 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Multimodal MRI evaluation of the mitopark mouse model of Parkinson's disease

Cong, L., Muir, E. R., Chen, C., Qian, Y., Liu, J., Biju, K. C., Clark, R. A., Li, S. & Duong, T. Q., Mar 2016, In: PloS one. 11, 3, e0151884.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Multimodal randomized functional MR imaging of the effects of methylene blue in the human brain

Rodriguez, P., Zhou, W., Barrett, D. W., Altmeyer, W., Gutierrez, J. E., Li, J., Lancaster, J. L., Gonzalez-Lima, F. & Duong, T. Q., 2016, In: Radiology. 281, 2, p. 516-526 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

27 Scopus citations

National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence

Oh, Y. S., Appel, L. J., Galis, Z. S., Hafler, D. A., He, J., Hernandez, A. L., Joe, B., Karumanchi, S. A., Maric-Bilkan, C., Mattson, D., Mehta, N. N., Randolph, G., Ryan, M., Sandberg, K., Titze, J., Tolunay, E., Toney, G. M. & Harrison, D. G., Aug 1 2016, In: Hypertension. 68, 2, p. 281-288 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

47 Scopus citations

Ontogeny of SERT expression and antidepressant-like response to escitalopram in wild-type and SERT mutant mice

Mitchell, N. C., Gould, G. G., Koek, W. & Daws, L. C., Aug 2016, In: Journal of Pharmacology and Experimental Therapeutics. 358, 2, p. 271-281 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport

Ramkumar, N., Stuart, D., Mironova, E., Bugay, V., Wang, S., Abraham, N., Ichihara, A., Stockand, J. D. & Kohan, D. E., Jul 1 2016, In: American Journal of Physiology - Renal Physiology. 311, 1, p. F186-F194

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Rescue of pressure overload-induced heart failure by estrogen therapy

Iorga, A., Li, J., Sharma, S., Umar, S., Bopassa, J. C., Nadadur, R. D., Centala, A., Ren, S., Saito, T., Toro, L., Wang, Y., Stefani, E. & Eghbali, M., Jan 1 2016, In: Journal of the American Heart Association. 5, 1, p. 1-12 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Spatiotemporal changes in blood-brain barrier permeability, cerebral blood flow, T₂ and diffusion following mild traumatic brain injury

Li, W., Watts, L., Long, J., Zhou, W., Shen, Q., Jiang, Z., Li, Y. & Duong, T. Q., Sep 1 2016, In: Brain Research. 1646, p. 53-61 9 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Spatiotemporal changes in diffusion, T₂ and susceptibility of white matter following mild traumatic brain injury

Li, W., Long, J. A., Watts, L., Shen, Q., Liu, Y., Jiang, Z. & Duong, T. Q., Jul 1 2016, In: NMR in Biomedicine. 29, 7, p. 896-903 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

T2 ∗-weighted fMRI time-to-peak of oxygen challenge in ischemic stroke

Shen, Q., Huang, S. & Duong, T. Q., Feb 1 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 2, p. 283-291 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Targeted overexpression of endothelial nitric oxide synthase in endothelial cells improves cerebrovascular reactivity in Ins2 Akita-type-1 diabetic mice

Chandra, S. B., Mohan, S., Ford, B. M., Huang, L., Janardhanan, P., Deo, K. S., Cong, L., Muir, E. R. & Duong, T. Q., Jun 1 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 6, p. 1135-1142 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Using high-speed chronoamperometry to measure biogenic amine release and uptake in vivo

Daws, L. C., Owens, W. A. & Toney, G. M., 2016, In: Neuromethods. 118, p. 53-81 29 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke

Metastroke Consortium, ISGC Consortium and Genestroke Consortium, Dec 2016, In: Thrombosis and Haemostasis. 116, 6, p. 1165-1171 7 p., A019.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2015

Activation of ENaC by AVP contributes to the urinary concentrating mechanism and dilution of plasma

Mironova, E., Chen, Y., Pao, A. C., Roos, K. P., Kohan, D. E., Bugaj, V. & Stockand, J. D., 2015, In: American Journal of Physiology - Renal Physiology. 308, 3, p. F237-F243

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Activation of the hypothalamic paraventricular nucleus by forebrain hypertonicity selectively increases tonic vasomotor sympathetic nerve activity

Holbein, W. W. & Toney, G. M., 2015, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 308, 5, p. R351-R359

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Antidepressant-like effects and basal immobility depend on age and serotonin transporter genotype

Mitchell, N. C., Koek, W. & Daws, L. C., Sep 1 2015, In: Genes, Brain and Behavior. 14, 7, p. 543-549 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Augmentation of M-type (KCNQ) potassium channels as a novel strategy to reduce stroke-induced brain injury

Bierbower, S. M., Choveau, F. S., Lechleiter, J. D. & Shapiro, M. S., 2015, In: Journal of Neuroscience. 35, 5, p. 2101-2111 11 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice

Hurez, V., Dao, V., Liu, A., Pandeswara, S., Gelfond, J., Sun, L., Bergman, M., Orihuela, C. J., Galvan, V., Padrón, Á., Drerup, J., Liu, Y., Hasty, P., Sharp, Z. D. & Curiel, T. J., Dec 1 2015, In: Aging cell. 14, 6, p. 945-956 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

94 Scopus citations

Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease

METASTROKE Consortium, CHARGE WMH Group, ISGC ICH GWAS Study Collaboration, WMH in Ischemic Stroke GWAS Study Collaboration & International Stroke Genetics Consortium, Mar 3 2015, In: Neurology. 84, 9, p. 918-926 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

104 Scopus citations

Connexin Controls Cell-Cycle Exit and Cell Differentiation by Directly Promoting Cytosolic Localization and Degradation of E3 Ligase Skp2

Shi, Q., Gu, S., Yu, X. S., White, T. W., Banks, E. A. & Jiang, J. X., 2015, In: Developmental Cell. 35, 4, p. 483-496 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Convergent genetic and expression data implicate immunity in Alzheimer's disease

International Genomics of Alzheimer's Disease Consortium (IGAP), Jun 1 2015, In: Alzheimer's and Dementia. 11, 6, p. 658-671 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

155 Scopus citations

Coordination and fine motor control depend on Drosophila TRPγ

Akitake, B., Ren, Q., Boiko, N., Ni, J., Sokabe, T., Stockand, J. D., Eaton, B. A. & Montell, C., Jun 1 2015, In: Nature communications. 6, 7288.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Corrigendum to Chronic inhibition of mTOR by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice [Neuroscience, 223, (2012), 102-113] DOI: 10.1016/j.neuroscience.2012.06.054

Halloran, J., Hussong, S. A., Burbank, R., Podlutskaya, N., Fischer, K. E., Sloane, L. B., Austad, S. N., Strong, R., Richardson, A., Hart, M. J. & Galvan, V., Oct 15 2015, In: Neuroscience. 306, p. 151 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

1 Scopus citations

Department of Cellular & Integrative Physiology

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