Biomolecular NMR

    Andrew Peterson Hinck (Manager)

Equipment/facility: Facility

    Description

    500 MHz NMR Spectrometer with AV--III console, 1.7mm microcryoprobe, sample autochanger and nitrogen liquifier. 600 MHz NMR Spectrometer with AV--I console and cryoprobe. 700 MHz NMR Spectrometer with AV--I console, cryoprobe and sample changer. Gilson Liquid Handling Robot. Discovery of novel small molecule inhibitors of defined macromolecular targets using NMR-based fragment screening. Mapping of interacting residues in macromolecular complexes, including an in-depth analysis of the thermodynamics and kinetics of binding. Metabolomic analysis of cell and tissue extracts. Structure determination of lipids, complex carbohydrates, and natural products. Three-dimensional structure determination of macromolecules and their complexes and atomic-resolution analyses of backbone dynamics (flexibility),</

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    Nuclear magnetic resonance
    Spectrometers
    Macromolecular Substances
    Tissue Extracts
    Biological Products
    Macromolecules
    Screening
    Nitrogen
    Carbohydrates
    Thermodynamics
    Robots
    Lipids
    Molecules
    Kinetics
    Liquids