Additional file 6: of Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma

Figure S6. STRINGdb visualizations of protein-protein interaction networks implicated by PTIM models. The protein-protein interaction networks here are derived from targets selected to define drug sensitivity during PTIM modeling. Edges in the STRINGdb graph represent confidence of interactions based on data from multiple published sources. Edges with confidence >â 0.9 are represented on the graph. The asterisk indicates targets validated in vitro. (A) Network of the set of targets common to the models developed for the GSK Orphan Kinome screen and the PPTI screen. Enrichment p-value