Additional file 13: of Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma

Figure S13. Circos plot of PCB490 RNA sequencing and exome sequencing data. ABL1 and NOTCH1 are identified as both mutated and amplified, though both variants were also identified in the matched germline sample. The outermost data circle represents log2-scaled gene expression [log2(expression+â 1), low expression (white) to high expression (red), with missing values colored black]. The middle circle represents genes with identified mutations or indels (red) or lack thereof (black). The innermost circle represents copy number variations (red is amplification, blue is deletion, black is no variation). (TIF 69008 kb)